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Experimental Investigation of the 2D Ion Beam Profile Generated by an ESI Octopole-QMS System

  • Research Article
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Journal of The American Society for Mass Spectrometry

Abstract

In this paper, we have employed an ion imaging approach to investigate the behavior of ions exiting from a quadrupole mass spectrometer (QMS) system that employs a radio frequency octopole ion guide before the QMS. An in-vacuum active pixel detector (Timepix) is employed at the exit of the QMS to image the ion patterns. The detector assembly simultaneously records the ion impact position and number of ions per pixel in every measurement frame. The transmission characteristics of the ion beam exiting the QMS are studied using this imaging detector under different operating conditions. Experimental results confirm that the ion spatial distribution exiting the QMS is heavily influenced by ion injection conditions. Furthermore, ion images from Timepix measurements of protein standards demonstrate the capability to enhance the quality of the mass spectral information and provide a detailed insight in the spatial distribution of different charge states (and hence different m/z) ions exiting the QMS.

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Acknowledgments

This work is part of the research program of the Foundation for Fundamental Research on Matter (FOM), which is part of the Netherlands Organization for Scientific Research (NWO). The research is supported by the Comprehensive Analytical Science and Technology (COAST) foundation, which is the assigned program committee in the NWO Technology Area for Sustainable Chemistry (TASC) program. The authors acknowledge Ronald Buijs, Marc Duursma, and Frans Giskes of AMOLF for their contribution to the experiments, and also Professor Stephen Taylor and Dr. Ken Evans of the University of Liverpool for their advice and constructive analysis during the course of this work.

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Authors and Affiliations

  1. FOM Institute AMOLF, Science Park 104, 1098 XG, Amsterdam, The Netherlands

    Sarfaraz U. A. H. Syed, Gert B. Eijkel, Piet Kistemaker, Shane Ellis, Donald F. Smith & Ron M. A. Heeren

  2. Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool, L69 3GJ, UK

    Simon Maher

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  1. Sarfaraz U. A. H. Syed
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  2. Gert B. Eijkel
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  3. Piet Kistemaker
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  4. Shane Ellis
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  5. Simon Maher
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  6. Donald F. Smith
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  7. Ron M. A. Heeren
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Correspondence to Ron M. A. Heeren.

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Syed, S.U.A.H., Eijkel, G.B., Kistemaker, P. et al. Experimental Investigation of the 2D Ion Beam Profile Generated by an ESI Octopole-QMS System. J. Am. Soc. Mass Spectrom. 25, 1780–1787 (2014). https://doi.org/10.1007/s13361-014-0958-0

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  • DOI: https://doi.org/10.1007/s13361-014-0958-0

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