Abstract
Synthetic biology, an emerging field of science and technology, intends to make of the natural world a substrate for engineering practice. Drawing inspiration from conventional engineering disciplines, practitioners of synthetic biology hope to make biological systems standardized, calculable, modular, and predictably functional. This essay develops a Heideggerian reading of synthetic biology as a useful perspective with which to identify and explore key facets of this field, its knowledge, its practices, and its products. After overviews of synthetic biology and Heidegger’s account of technology, I discuss calculability, utility, function, setting-upon, and ordering, with the aim of discussing the manner in which synthetic biology works to render the biological world intelligible as something to be used, rather than something that is in and of itself. Having developed this Heideggerian reading, I proffer a number of corrections to his account that enable a more accurate, nuanced understanding of synthetic biology. Specifically, I discuss the notion of Ge-stell and submit that multiple systems of “enframing” may help to make Heidegger’s argument more robust. I suggest that synthetic biology may work to reveal the natural world as a standing-reserve of function.
Similar content being viewed by others
Notes
For Heidegger, only a dedicated exploration of technology’s essence can free us from the dangerous, obliging relationship that characterizes our interaction with technology (see Dreyfus 1997).
The German Bestand is generally translated as “standing reserve.” Rouse suggests that Bestand describes that which is “standing on call” (1985: 81). Ultimately, the concept refers to resources of which humanity may avail itself.
Quantum mechanics’ focus on probability, rather than complete determinacy, is often employed to challenge this facet of Heidegger’s argument. Nonetheless, quantum mechanics also implies that only what has been measured can be known, thus lending credence to Heidegger’s argument that human metrics are the basis for what is real (see Glazebrook 2000, Chapter 5). Ultimately, my focus is synthetic biology, not quantum physics, so the point is only of tangential interest.
Put otherwise, living things are transformed into things of human artifice with human-specified functions (c.f. Author, forthcoming, for an extended discussion of this particular issue).
While it may be possible to argue that poiesis is synonymous with craft practice, I do not believe that this craft practice is of the kind found in scientific research. Moreover, synthetic biologists explicitly advocate a move away from craft to ‘real’ engineering.
Note that my focus here is technological function, rather than biological function. In other work, I explore the connection between these concepts within synthetic biology.
References
Ajo-Franklin, C. M., Drubin, D. A., Eskin, J. A., Gee, E., Landgraf, D., Phillips, I., et al. (2007). Rational design of memory in eukaryotic cells. Genes & Development, 21, 2271–2276.
Anderson, J. C., Clarke, E. J., Arkin, A. P., & Voigt, C. A. (2005). Environmentally controlled invasion of cancer cells by engineered bacteria. Journal of Molecular Biology, 355, 619–627.
Andrianantoandro, E., Basu S., Karig, D.K., & Weiss, R. (2006). Synthetic biology: New engineering rules for an emerging discipline. Molecular Systems Biology 2.
Arkin, A. (2008). Setting the standard in synthetic biology. Nature Biotechnology, 26(7), 771–774.
Burrill, D. R., & Silver, P. A. (2010). Making cellular memories. Cell, 140(1), 13–18.
Canton, B., Labno, A., & Endy, D. (2008). Refinement and standardization of synthetic biological parts and devices. Nature Biotechnology, 26(7), 787–793.
Chopra, P., & Kamma, A. (2006). Engineering life through synthetic biology. Silico Biology, 6(5), 401–410.
Dreyfus, H. (1997). Heidegger on gaining a free relationship to technology. In K. Shrader-Frechette & L. Westra (Eds.), Technology and values (pp. 41–53). Oxford: Rowman & Littlefield.
Elowitz, M., & Leibler, S. (2000). A synthetic oscillator network of transcriptional regulators. Nature, 403, 335–338.
Endy, D. (2005). Foundations for engineering biology. Nature, 438(24), 449–453.
Feenberg, A. (2005). Heidegger and Marcuse. London: Routledge.
Glazebrook, T. (2000). Heidegger’s philosophy of science. New York: Fordham University Press.
Glazebrook, T. (2001). Heidegger and scientific realism. Continental Philosophy Review, 34, 361–401.
Hartwell, L. H., Hopfield, J. J., Leibler, S., & Murray, A. W. (1999). From molecular to modular cell biology. Nature, 402, C47–C52.
Heidegger, M. (1969 [1959]). In J. M. Anderson & H. Freund (Eds.), Discourse on thinking. New York, NY: Harper & Row.
Heidegger, M. (1977). Modern science, metaphysics, and mathematics. In D. F. Krell (Ed.), Martin Heidegger: basic writings (pp. 247–282). New York, NY: Harper & Row.
Heidegger, M. (1982a [1977]). The question concerning technology. In W. Lovitt (Ed.), The question concerning technology and other essays (pp. 3–35). New York, NY: Harper & Row.
Heidegger, M. (1982b [1977]). The age of the world picture. In W. Lovitt (Ed.), The question concerning technology and other essays (pp. 115–154). New York, NY: Harper & Row.
Heidegger, M. (1982c [1977]). Science and reflection. In W. Lovitt (Ed.), The question concerning technology and other essays (pp. 155–182). New York, NY: Harper & Row.
Heidegger, M. (2000 [1953]). In G. Fried & R. Polt (Eds.), Introduction to metaphysics. New Haven, CT: Yale University Press.
Heidegger, M. (2001 [1971]). The thing. In A. Hofstadter (Ed.), Poetry, language, thought (pp. 161–184). New York, NY: Harper Collins.
Heidegger, M. (2005 [1927]). In J. Macquarrie & E. Robinson (Eds.), Being and time. Oxford: Blackwell.
Heinemann, M., & Panke, S. (2006). Synthetic biology: putting engineering into biology. Bioinformatics, 22(22), 2790–2799.
Hood, W. F. (1972). The Aristotelian versus the Heideggerian approach to the problem of technology. In C. Mitcham & R. Mackey (Eds.), Philosophy and technology (pp. 347–363). New York, NY: Free Press.
Keasling, J., Vincent, M., Pitera, D., Kim, S.-W., Sydnor, W. T., Yasuo, Y., et al. (2007). USPTO patent application 20070166782: biosynthesis of isopentenyl pyrophosphate.
Kwok, R. (2010). Five hard truths for synthetic biology. Nature, 463, 288–290.
Lovitt, W. (1973). A Gespräch with Heidegger on technology. Man and World, 6(1), 44–62.
Lovitt, W. (1982). Introduction. In W. Lovitt (Ed.), The question concerning technology and other essays (pp. xiii–xxxix). New York, NY: Harper & Row.
Lovitt, W., & Lovitt, H. B. (1995). Modern technology in the Heideggerian perspective. Lewiston, NY: Edwin Mellen.
Mayr, E. (2004). What makes biology unique? Cambridge: Cambridge University Press.
McDaniel, R., & Weiss, R. (2005). Advances in synthetic biology. Current Opinion in Biotechnology, 16(4), 476–483.
Nature Editorial Board. (2007). Meanings of ‘life’. Nature, 447, 1031–1032.
Purnick, P., & Weiss, R. (2009). The second wave of synthetic biology. Nature Reviews Molecular Cell Biology, 10(6), 410–422.
Rouse, J. (1985). Heidegger’s later philosophy of science. Southern Journal of Philosophy, 23(1), 75–92.
Sanders, R. (2010). NSF grant to launch world’s first open-source genetic parts production facility. Genetics Engineering & Biotechnology News, January 20.
Sauro, H. M. (2008). Modularity defined. Molecular Systems Biology, 4, 166.
Savage, D. F., Way, J., & Silver, P. A. (2008). Defossiling fuel: how synthetic biology can transform biofuel production. ACS Chemical Biology, 3(1), 13–16.
Vincenti, W. (1990). What engineers know and how they know it. Baltimore, MD: Johns Hopkins University Press.
Voigt, C. (2011). Breaking complex gene clusters into parts: refactoring nitrogen fixation. Fifth International Meeting on Synthetic Biology.
Yeh, B. J., & Lim, W. A. (2007). Synthetic biology: lessons from the history of synthetic organic chemistry. Nature Chemical Biology, 3, 521–525.
Zimmerman, M. E. (1977). Beyond humanism: Heidegger’s understanding of technology. Listening, 12(3), 74–83.
Zimmerman, M. E. (1990). Heidegger’s confrontation with modernity. Bloomington, IN: Indiana University Press.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Schyfter, P. Standing Reserves of Function: A Heideggerian Reading of Synthetic Biology. Philos. Technol. 25, 199–219 (2012). https://doi.org/10.1007/s13347-011-0053-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13347-011-0053-4