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Effect of gamma irradiation on drug releasing from nano-bioactive glass

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Abstract

In this work, we studied the effect of gamma irradiation on nano-bioactive glass (NBG) structure, bioactivity, drug loading efficiency, and drug release kinetic. Gamma irradiation was mainly introduced as a safe and cheap method to tailor the drug loading and release efficiencies. NBG was investigated before and after gamma irradiation with two doses 25 and 50 kGy. Vancomycin antibiotic was used as a drug model, and different kinetic models (first order, Higuchi, Hixson-Crowell, and Baker-Lonsdale models) were used to study the mechanism of drug release. It was found that G25 sample showed the lowest affinity for vancomycin adsorption, but it showed the highest release rate. Also, vancomycin was released from all samples by diffusion mechanism from spherically shaped carrier. On the other hand, the bioactivity of NBG was not altered by gamma irradiation; in contrary, newly formed apatite layers were more well-crystalline.

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Acknowledgments

The authors would like to thank the National Research Center, National Center for Radiation Research and Technology, and Faculty of Science, Al-Azhar University (Girls), located in Egypt, for a possibility to use their facilities.

Conflict of interest

The authors stated that there are no conflicts of interest.

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Authors and Affiliations

  1. Biomaterials Department, National Research Center, 33 El-Bohooth St., Dokki, Giza, 12622, Egypt

    M. M. Farag

  2. Radiation Chem. Department, National Center for Radiation Research and Technology, Cairo, Egypt

    W. M. Abd-Allah

  3. Physics Department (Biophysics Branch), Faculty of Science, Al-Azhar University (Girls), Cairo, Egypt

    A. M. Ibrahim

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  1. M. M. Farag
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  3. A. M. Ibrahim
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Correspondence to M. M. Farag.

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Farag, M.M., Abd-Allah, W.M. & Ibrahim, A.M. Effect of gamma irradiation on drug releasing from nano-bioactive glass. Drug Deliv. and Transl. Res. 5, 63–73 (2015). https://doi.org/10.1007/s13346-014-0214-y

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