Review Article

Drug Delivery and Translational Research

, Volume 3, Issue 4, pp 352-363

Dual-function theranostic nanoparticles for drug delivery and medical imaging contrast: perspectives and challenges for use in lung diseases

  • M. HowellAffiliated withMolecular Medicine Department, University of South FloridaNanomedicine Research Center, University of South Florida
  • , C. WangAffiliated withMolecular Medicine Department, University of South FloridaNanomedicine Research Center, University of South Florida
  • , A. MahmoudAffiliated withNanomedicine Research Center, University of South FloridaChemical and Biomedical Engineering Department and Molecular Medicine Department, University of South Florida
  • , G. HellermannAffiliated withNanomedicine Research Center, University of South FloridaDivision of Translational Medicine, Department of Internal Medicine Morsani College of Medicine, University of South Florida
  • , S. S. MohapatraAffiliated withNanomedicine Research Center, University of South FloridaDivision of Translational Medicine, Department of Internal Medicine Morsani College of Medicine, University of South Florida
  • , S. MohapatraAffiliated withMolecular Medicine Department, University of South FloridaNanomedicine Research Center, University of South Florida Email author 

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Abstract

Theranostic nanoparticles with both therapeutic and imaging abilities have the promise to revolutionize diagnosis, therapy, and prognosis. Early and accurate detection along with swift treatment are the most important steps in the successful treatment of any disease. Over the last decade, a variety of nanotechnology-based platforms have been created in the hope of improving the treatment and diagnosis of a wide variety of diseases. However, significant hurdles still remain before theranostic nanoparticles can bring clinical solutions to the fight against chronic respiratory diseases. Some fundamental issues such as long-term toxicity, a precise understanding of the accumulation, degradation and clearance of these particles, and the correlation between basic physicochemical properties of these nanoparticles and their in vivo behavior have to be fully understood before they can be used clinically. To date, very little theranostic nanoparticle research has focused on the treatment and diagnosis of chronic respiratory illnesses. Nanomedicine approaches incorporating these theranostic nanoparticles could potentially be translated into clinical advances to improve diagnosis and treatment of these chronic respiratory diseases and enhance quality of life for the patients.

Keywords

Chronic respiratory diseases Theranostics Nanoparticles