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Turkish version of the Michigan Neuropathy Screening Instrument in the assessment of diabetic peripheral neuropathy: a validity and reliability study

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Abstract

Background/aim

Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). The Michigan Neuropathy Screening Instrument (MNSI) is a simple, brief, and useful screening tool that was designed to assess DPN. The aim of this study was to develop a Turkish version of the MNSI and assess its reliability and validity.

Materials and methods

Eighty-three patients with DM who were divided into two groups according the results of nerve conduction studies (NCS) as having DPN or without DPN were enrolled in this cross-sectional study. The Toronto clinical scoring system, pain detect questionnaire, and NCS were assessed along with the MNSI.

Results

Each section of the MNSI was internally consistent (Cronbach’s alpha > 0.70), and the scores of both sections were positively correlated with total MNSI score (r = 0.938; r = 0.908, respectively, p < 0.001). The test–retest reliability of the Turkish version of the MNSI was determined as 0.99 for the total score (intraclass correlation coefficient = 0.996). Using the agreement between MNSI scores and DPN diagnosis by NCS as a gold standard, receiver-operating characteristic (ROC) curve values for section A and section B were estimated as 0.973 and 1.00, respectively. When a cut-off value ≥ 3.0 in section A and a cut-off value ≥ 2.0 in section B were used, we obtained a sensitivity of 97.6% and 100%; a specificity of 63.4% and 97.6%; a positive predictive value of 72.7% and 97.6%; and a negative predictive value of 96.3% and 100%, respectively.

Conclusion

The Turkish version of MNSI is a reliable and valid tool for screening DPN in Turkish patients.

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Acknowledgements

The authors would like to thank Füsun Ardıç and Necmettin Yıldız.

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Authors and Affiliations

  1. Department of Rheumatology, Faculty of Medicine, Pamukkale University, Kınıklı, 20070, Denizli, Turkey

    Serdar Kaymaz, Ugur Karasu & Veli Çobankara

  2. Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Pamukkale University, Denizli, Turkey

    Hakan Alkan

Authors
  1. Serdar Kaymaz
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  2. Hakan Alkan
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  3. Ugur Karasu
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  4. Veli Çobankara
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Correspondence to Serdar Kaymaz.

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Authors do not have anything to disclose and declare no conflict of interest.

Human rights statement

The study “Turkish version of the Michigan Neuropathy Screening Instrument in the assessment of diabetic peripheral neuropathy: A validity and reliability study” was conducted in agreement with the Institutional Ethical Review Board of Pamukkale University Institute of Higher Education and Research, Denizli, Turkey (Approval Number: 60116787-020/54845, Date: 09/08/2019).

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Informed consent was obtained from the participants before they were included in the study.

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Appendix

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Michigan Nöropati Tarama Testi

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Kaymaz, S., Alkan, H., Karasu, U. et al. Turkish version of the Michigan Neuropathy Screening Instrument in the assessment of diabetic peripheral neuropathy: a validity and reliability study. Diabetol Int 11, 283–292 (2020). https://doi.org/10.1007/s13340-020-00427-9

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  • DOI: https://doi.org/10.1007/s13340-020-00427-9

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