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Programmed death 1 expression in the peritumoral microenvironment is associated with a poorer prognosis in classical Hodgkin lymphoma

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Tumor Biology

Abstract

Programmed cell death protein-1 (PD-1) inhibitor may be therapeutic in patients with relapsed or refractory classical Hodgkin’s lymphoma (cHL). This study examined the prognostic significance of PD-1 and two PD-1 ligands (PD-L1 and PD-L2) in uniformly treated cHL. Diagnostic tissues from 109 cHL patients treated with a doxorubicin, bleomycin, vinblastine, and dacarbazine regimen were evaluated retrospectively by immunohistochemical analysis of PD-L1, PD-L2, and PD-1 expressions. The median follow-up time was 4.91 years (range, 0.17–17.33 years). Thirteen patients (11 %) expressed PD-1 protein in the peritumoral microenvironment, which was associated with poor overall survival (OS) (P = 0.017). PD-L1 or PD-L2 expression was not associated with OS. There was no correlation between PD-L1 and PD-1 expression or between PD-L2 and PD-1 expression. Multivariate analysis identified PD-1 protein as an independent prognostic factor for OS (P = 0.019). Subgroup analysis according to the Ann Arbor stage of cHL showed that PD-1 protein expression had a prognostic value in limited-stage cHL (P = 0.048). PD-1 is an independent prognostic factor in cHL and may allow the identification of a subgroup of patients with limited-stage cHL who require more intensive therapy and who may benefit from anti-PD-1 agents.

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Acknowledgments

This study was supported by a grant (2011-090) from the Asan Institute for Life Sciences, Seoul, Korea.

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Authors and Affiliations

  1. Department of Pathology, Ajou University School of Medicine, Suwon, South Korea

    Young Wha Koh

  2. Department of Pathology, Seoul National University Hospital, Seoul, South Korea

    Yoon Kyung Jeon

  3. Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Dok Hyun Yoon & Cheolwon Suh

  4. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Seoul, 138-736, South Korea

    Jooryung Huh

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  1. Young Wha Koh
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Correspondence to Jooryung Huh.

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Koh, Y.W., Jeon, Y.K., Yoon, D.H. et al. Programmed death 1 expression in the peritumoral microenvironment is associated with a poorer prognosis in classical Hodgkin lymphoma. Tumor Biol. 37, 7507–7514 (2016). https://doi.org/10.1007/s13277-015-4622-5

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  • DOI: https://doi.org/10.1007/s13277-015-4622-5

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