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MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2

  • Research Article
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Tumor Biology

Abstract

Ovarian cancer (OC) is a major cancer-related mortality among women. Recent studies suggest that many microRNAs (miRNAs) were dysregulated and involved in tumorigenesis of OC. The present study investigated the role of miR-25 in the development and progression of OC. The expression of miR-25 was increased in OC tissues and cell lines. Inhibition of miR-25 remarkably suppressed proliferation, migration, and invasion of OC cells. Large tumor suppressor 2 (LATS2), a tumor suppressor, was confirmed to be a direct target of miR-25 in OC cells. Moreover, restoration of LATS2 significantly attenuated the oncogenic effects of miR-25. Together, our data suggest an oncogenic role of miR-25 in OC and a potentially novel diagnostic and therapeutic target for OC treatment.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Harbin Medical University, 150001, Harbin, China

    Shujun Feng, Wenjing Pan, Ye Jin & Jianhua Zheng

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  1. Shujun Feng
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  2. Wenjing Pan
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  3. Ye Jin
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  4. Jianhua Zheng
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Correspondence to Jianhua Zheng.

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Feng, S., Pan, W., Jin, Y. et al. MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2. Tumor Biol. 35, 12339–12344 (2014). https://doi.org/10.1007/s13277-014-2546-0

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  • DOI: https://doi.org/10.1007/s13277-014-2546-0

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