Skip to main content

Advertisement

SpringerLink
Log in

Collagen triple helix repeat containing 1 (Cthrc1) is an independently prognostic biomarker of non-small cell lung cancers with cigarette smoke

  • Research Article
  • Published:
Tumor Biology

Abstract

Collagen triple helix repeat containing 1 (Cthrc1) has been recently documented in various malignancies, but its role in non-small cell lung cancer (NSCLC) remains uncertain. In the current study, we investigated the level of Cthrc1 in NSCLC tissues by immunohistochemistry. Results revealed that Cthrc1 overexpression was significantly associated with differentiation (P = 0.039), tumor–node–metastasis (TNM) stage (P = 0.035), lymph node status (P = 0.001), and cigarette smoke (P = 0.037). Furthermore, it was shown that patients with high Cthrc1 expression had significantly poorer overall survival (OS) and disease-free survival (DFS; P = 0.004 and P = 0.010, respectively). Interestingly, high Cthrc1 expression was an independent prognostic factor for both OS and DFS (P = 0.010 and P = 0.005, respectively) only in NSCLCs with cigarette smoke. These results indicated and suggested that Cthrc1 could be used as a prognostic marker for NSCLC, and it may play an important role in the smoked-related NSCLC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277–300.

    Article  PubMed  Google Scholar 

  2. Devesa SS, Bray F, Vizcaino AP, Parkin DM. International lung cancer trends by histologic type: male: female differences diminishing and adenocarcinoma rates rising. Int J Cancer. 2005;117:294–9.

    Article  CAS  PubMed  Google Scholar 

  3. Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006;24:2137–50.

    Article  PubMed  Google Scholar 

  4. Lawrence RE, Salgia R. MET molecular mechanisms and therapies in lung cancer. Cell Adhes Migr. 2010;4:146–52.

    Article  Google Scholar 

  5. Chen HY, Yu SL, Chen CH, Chang GC, Chen CY, Yuan A, et al. A five-gene signature and clinical outcome in non-small-cell lung cancer. N Engl J Med. 2007;356:11–20.

    Article  CAS  PubMed  Google Scholar 

  6. Liotta LA, Steeg PS, Stetler-Stevenson WG. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell. 1991;64:327–36.

    Article  CAS  PubMed  Google Scholar 

  7. O’Mahony D, Kummar S, Gutierrez ME. Non-small-cell lung cancer vaccine therapy: a concise review. J Clin Oncol. 2005;23:9022–8.

    Article  PubMed  Google Scholar 

  8. Pyagay P, Heroult M, Wang Q, Lehnert W, Belden J, Liaw L, et al. Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ Res. 2005;96:261–8.

    Article  CAS  PubMed  Google Scholar 

  9. Tameda M, Sugimoto K, Shiraki K, Yamamoto N, Okamoto R, Usui M, et al. Collagen triple helix repeat containing 1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation and motility. Int J Oncol. 2014;45:541–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  10. Tang L, Dai DL, Su M, Martinka M, Li G, Zhou Y. Aberrant expression of collagen triple helix repeat containing 1 in human solid cancers. Clin Cancer Res. 2006;12:3716–22.

    Article  CAS  PubMed  Google Scholar 

  11. Ip W, Wellman-Labadie O, Tang L, Su M, Yu R, Dutz J, et al. Collagen triple helix repeat containing 1 promotes melanoma cell adhesion and survival. J Cutan Med Surg. 2011;15:103–10.

    CAS  PubMed  Google Scholar 

  12. Wang P, Wang YC, Chen XY, Shen ZY, Cao H, Zhang YJ, et al. CTHRC1 is upregulated by promoter demethylation and transforming growth factor-β1 and may be associated with metastasis in human gastric cancer. Cancer Sci. 2012;103:1327–33.

    Article  CAS  PubMed  Google Scholar 

  13. Jacques J, Hill DP, Shier KJ, Jindani A, Miller AB. Appraisal of the World Health Organization classification of lung tumours. Can Med Assoc J. 1980;122:897–901.

    CAS  PubMed Central  PubMed  Google Scholar 

  14. Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, Rami-Porta R, et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol. 2007;2:706–14.

    Article  PubMed  Google Scholar 

  15. Kharaishvili G, Cizkova M, Bouchalova K, Mgebrishvili G, Kolar Z, Bouchal J. Collagen triple helix repeat containing 1 protein, periostin and versican in primary and metastatic breast cancer: an immunohistochemical study. J Clin Pathol. 2011;64:977–82.

    Article  PubMed  Google Scholar 

  16. Orloff M, Peterson C, He X, Ganapathi S, Heald B, Yang YR, et al. Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. JAMA. 2011;306:410–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Park EH, Kim S, Jo JY, Kim SJ, Hwang Y, Kim JM, et al. Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells. Carcinogenesis. 2013;34:694–702.

    Article  CAS  PubMed  Google Scholar 

  18. Li J, Zhang Z, Li G. Patient outcome prediction using multiple biomarkers in human melanoma: a clinicopathological study of 118 cases. Exp Ther Med. 2011;2:131–5.

    PubMed Central  PubMed  Google Scholar 

  19. Gu L, Liu L, Zhong L, Bai Y, Sui H, Wei X, et al. Cthrc1 overexpression is an independent prognostic marker in gastric cancer. Hum Pathol. 2014;45:1031–8.

    Article  CAS  PubMed  Google Scholar 

  20. Kim JH, Baek TH, Yim HS, Kim KH, Jeong SH, Kang HB, et al. Collagen triple helix repeat containing-1 (CTHRC1) expression in invasive ductal carcinoma of the breast: the impact on prognosis and correlation to clinicopathologic features. Pathol Oncol Res. 2013;19:731–7.

    Article  CAS  PubMed  Google Scholar 

  21. Tan F, Liu F, Liu H, Hu Y, Liu D, Li G. CTHRC1 is associated with peritoneal carcinomatosis in colorectal cancer: a new predictor for prognosis. Med Oncol. 2013;30:473.

    Article  PubMed  Google Scholar 

  22. Pitule P, Vycital O, Bruha J, Novak P, Hosek P, Treska V, et al. Differential expression and prognostic role of selected genes in colorectal cancer patients. Anticancer Res. 2013;33:4855–65.

    CAS  PubMed  Google Scholar 

  23. Chen YL, Wang TH, Hsu HC, Yuan RH, Jeng YM. Overexpression of CTHRC1 in hepatocellular carcinoma promotes tumor invasion and predicts poor prognosis. PLoS One. 2013;8:e70324.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Kim HC, Kim YS, Oh HW, Kim K, Oh SS, Kim JT, et al. Collagen triple helix repeat containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells. Oncotarget. 2014;5:519–29.

    PubMed Central  PubMed  Google Scholar 

  25. Kelley MW. Leading Wnt down a PCP path: Cthrc1 acts as a coreceptor in the Wnt-PCP pathway. Dev Cell. 2008;15:7–8.

    Article  CAS  PubMed  Google Scholar 

  26. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9–29.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work is supported by Heilongjiang Provincial Health Department issues (no. 2009-114).

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Department of Emergency, The Second Affiliated Hospital of Harbin Medical University, Harbin, China

    Xiaojun Liu, Beiyan Liu, Fengping Wang & Hui Sun

  2. Blood Center, Harbin Medical University, Harbin, China

    Ying Cui

  3. Department of Respiratory, The Second Affiliated Hospital of Harbin Medical University, 150081, Harbin, People’s Republic of China

    Fuzhen Lv

Authors
  1. Xiaojun Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Beiyan Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ying Cui
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fengping Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hui Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Fuzhen Lv
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fuzhen Lv.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, X., Liu, B., Cui, Y. et al. Collagen triple helix repeat containing 1 (Cthrc1) is an independently prognostic biomarker of non-small cell lung cancers with cigarette smoke. Tumor Biol. 35, 11677–11683 (2014). https://doi.org/10.1007/s13277-014-2449-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-014-2449-0

Keywords

Search

Navigation