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Relationships of FOXE1 and ATM genetic polymorphisms with papillary thyroid carcinoma risk: a meta-analysis

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Tumor Biology

Abstract

We conducted the meta-analysis of all relevant case–control studies aiming to evaluate the relationships of common polymorphisms in forkhead box E1 (FOXE1) and ataxia telangiectasia mutated (ATM) genes to the risk of papillary thyroid carcinoma (PTC). A range of electronic databases were searched without language restrictions: Web of Science (1945 ~ 2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966 ~ 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013). This meta-analysis was conducted using the STATA 12.0 software. Crude odds ratio (OR) with their 95 % confidence interval (CI) were calculated. Eight case–control studies with 2,085 PTC patients and 10,341 healthy controls were included. Fourteen common polymorphisms were evaluated, including rs3758249 A > G, rs907577 G > A, rs1867277 G > A, rs3021526 C > T, rs1443434 G > T, rs907580 G > A, rs965513 A > G, rs944289 C > T, and rs189037 G > A polymorphisms in the FOXE1 gene and rs373759 G > A, rs4988099 A > G, rs1801516 G > A, rs664677 T > C, and rs609429 G > C polymorphisms in the ATM gene. Our results demonstrated that the FOXE genetic polymorphisms might be closely related to an increased risk of developing PTC under five genetic models (all P < 0.005), especially for rs3758249, rs907577, rs1867277, rs3021526, rs1443434, rs907580, rs704839, rs894673, and rs10119760 polymorphisms. Nevertheless, no positive associations were found between the ATM genetic polymorphisms and the development of PTC (all P > 0.05). The current meta-analysis provided evidence that FOXE1 genetic polymorphisms may contribute to increased PTC risk, especially for rs3758249, rs907577, rs1867277, rs3021526, rs1443434, rs907580, rs704839, rs894673, and rs10119760 polymorphisms. However, the ATM genetic polymorphisms may not be important dominants of susceptibility to PTC.

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References

  1. He H, Bronisz A, Liyanarachchi S, Nagy R, Li W, Huang Y, et al. Srgap1 is a candidate gene for papillary thyroid carcinoma susceptibility. J Clin Endocrinol Metab. 2013;98(5):E973–80.

    Article  PubMed Central  PubMed  Google Scholar 

  2. LiVolsi VA. Papillary thyroid carcinoma: an update. Mod Pathol. 2011;24 Suppl 2:S1–9.

    Article  CAS  PubMed  Google Scholar 

  3. Kim TH, Park YJ, Lim JA, Ahn HY, Lee EK, Lee YJ, et al. The association of the BRAF(V600E) mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer: a meta-analysis. Cancer. 2012;118(7):1764–73.

    Article  CAS  PubMed  Google Scholar 

  4. Koea JB, Shaw JH. Parathyroid cancer: biology and management. Surg Oncol. 1999;8(3):155–65.

    Article  CAS  PubMed  Google Scholar 

  5. Lloyd RV, Buehler D, Khanafshar E. Papillary thyroid carcinoma variants. Head Neck Pathol. 2011;5(1):51–6.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Nikiforov YE. Radiation-induced thyroid cancer: what we have learned from chernobyl. Endocr Pathol. 2006;17(4):307–17.

    Article  CAS  PubMed  Google Scholar 

  7. Damiola F, Byrnes G, Moissonnier M, Pertesi M, Deltour I, Fillon A, et al. Contribution of ATM and FOXE1 (TTF2) to risk of papillary thyroid carcinoma in Belarusian children exposed to radiation. Int J Cancer. 2014;134(7):1659–68.

    Article  CAS  PubMed  Google Scholar 

  8. Bullock M, Duncan EL, O’Neill C, Tacon L, Sywak M, Sidhu S, et al. Association of FOXE1 polyalanine repeat region with papillary thyroid cancer. J Clin Endocrinol Metab. 2012;97(9):E1814–9.

    Article  CAS  PubMed  Google Scholar 

  9. Matsuse M, Takahashi M, Mitsutake N, Nishihara E, Hirokawa M, Kawaguchi T, et al. The FOXE1 and NKX2-1 LOCI are associated with susceptibility to papillary thyroid carcinoma in the Japanese population. J Med Genet. 2011;48(9):645–8.

    Article  CAS  PubMed  Google Scholar 

  10. Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Perez L, Schiavi F, Leskela S, et al. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. PLoS Genet. 2009;5(9):e1000637.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Gilbert F, Kauff N. Disease genes and chromosomes: disease maps of the human genome. Chromosome 9. Genet Test. 2001;5(2):157–74.

    Article  CAS  PubMed  Google Scholar 

  12. Bychkov A, Saenko V, Nakashima M, Mitsutake N, Rogounovitch T, Nikitski A, et al. Patterns of FOXE1 expression in papillary thyroid carcinoma by immunohistochemistry. Thyroid. 2013;23(7):817–28.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Valentin-Vega YA, Kastan MB. A new role for ATM: regulating mitochondrial function and mitophagy. Autophagy. 2012;8(5):840–1.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Derheimer FA, Kastan MB. Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett. 2010;584(17):3675–81.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Platzer M, Rotman G, Bauer D, Uziel T, Savitsky K, Bar-Shira A, et al. Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire atm gene. Genome Res. 1997;7(6):592–605.

    CAS  PubMed  Google Scholar 

  16. Akulevich NM, Saenko VA, Rogounovitch TI, Drozd VM, Lushnikov EF, Ivanov VK, et al. Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. Endocr Relat Cancer. 2009;16(2):491–503.

    Article  CAS  PubMed  Google Scholar 

  17. Gu Y, Yu Y, Ai L, Shi J, Liu X, Sun H, et al. (2013) Association of the ATM gene polymorphisms with papillary thyroid cancer. Endocrine

  18. Liu C, Jiang YX, Chen C, Sun CZ, Zhao M. Correlation of FOXE1 gene polymorphism with papilliary thyroid carcinoma in Yunnan China. Journal of Modern Oncology. 2013;9:1958–63.

    Google Scholar 

  19. Damiola F, Byrnes G, Moissonnier M, Pertesi M, Deltour I, Fillon A, et al. Contribution of ATM and FOXE1 (TTF2) to risk of papillary thyroid carcinoma in Belarusian children exposed to radiation. Int J Cancer. 2013

  20. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–5.

    Article  PubMed  Google Scholar 

  21. Zintzaras E, Ioannidis JP. Hegesma: genome search meta-analysis and heterogeneity testing. Bioinformatics. 2005;21(18):3672–3.

    Article  CAS  PubMed  Google Scholar 

  22. Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L. Comparison of two methods to detect publication bias in meta-analysis. JAMA. 2006;295(6):676–80.

    Article  CAS  PubMed  Google Scholar 

  23. Kallel R, Belguith-Maalej S, Akdi A, Mnif M, Charfeddine I, Galofre P, et al. Genetic investigation of FOXE1 polyalanine tract in thyroid diseases: new insight on the role of FOXE1 in thyroid carcinoma. Cancer Biomark. 2010;8(1):43–51.

    CAS  PubMed  Google Scholar 

  24. Rodriguez W, Jin L, Janssens V, Pierreux C, Hick AC, Urizar E, et al. Deletion of the RNaseIII enzyme dicer in thyroid follicular cells causes hypothyroidism with signs of neoplastic alterations. PLoS One. 2012;7(1):e29929.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  25. Sordet O, Redon CE, Guirouilh-Barbat J, Smith S, Solier S, Douarre C, et al. Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. EMBO Rep. 2009;10(8):887–93.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Acknowledgments

We would like to acknowledge the reviewers for their helpful comments on this paper.

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Authors and Affiliations

  1. Center of Thyroid and Parathyroid, Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Yishan Road No. 600, Xuhui District, 200000, Shanghai, People’s Republic of China

    Jie Kang, Xian-Zhao Deng, You-Ben Fan & Bo Wu

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  1. Jie Kang
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  2. Xian-Zhao Deng
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Correspondence to Bo Wu.

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Kang, J., Deng, XZ., Fan, YB. et al. Relationships of FOXE1 and ATM genetic polymorphisms with papillary thyroid carcinoma risk: a meta-analysis. Tumor Biol. 35, 7085–7096 (2014). https://doi.org/10.1007/s13277-014-1865-5

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  • DOI: https://doi.org/10.1007/s13277-014-1865-5

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