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Haplotype-based case–control study of DNA repair gene XRCC3 and hepatocellular carcinoma risk in a Chinese population

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Tumor Biology

Abstract

Previous studies indicated that the human X-ray repair complementing group 3 gene (XRCC3) plays an important role in hepatocellular carcinoma (HCC) susceptibility. We aimed to investigate the association of XRCC3 genetic polymorphism with HCC risk. This study was conducted in a Chinese Han population consisting of 300 HCC cases and 300 sex- and age-matched cancer-free controls. Three genetic variants (rs861539, rs12432907, and rs861537) were genotyped by the TaqMan® SNP Genotyping Assay. Our findings suggested that the TT genotype and T allele from rs861539 genetic variants were statistically associated with HCC risk. The TT genotype was statistically associated with the increased risk of HCC compared to CC wild genotype (P < 0.001). And the T allele was more common in the HCC patients than that in the control subjects. (OR = 1.97, 95 % confidence interval (CI) 1.457 ~ 2.659, P < 0.001). Haplotype-based case–control study analysis indicated that TTG haplotype was more frequent in HCC groups than in the control group (odds ratio (OR) = 1.967, 95 % CI 1.456 ~ 2.658); however, the CTG haplotype is more common in the control group than that in the HCC group (OR = 0.550, 95 % CI 0.430 ~ 0.703; P < 0.001). Our data indicated that genetic variants of the XRCC3 gene were statistically associated with HCC risk in a Chinese population.

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Authors and Affiliations

  1. Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China

    Hong-Chun Luo, Xiao-Juan Xin & Wen-Xiang Huang

  2. Department of Hemotology, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Chongqing, 400016, People’s Republic of China

    Hong-Bin Zhang

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  1. Hong-Chun Luo
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  2. Hong-Bin Zhang
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  4. Wen-Xiang Huang
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Correspondence to Hong-Bin Zhang.

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Luo, HC., Zhang, HB., Xin, XJ. et al. Haplotype-based case–control study of DNA repair gene XRCC3 and hepatocellular carcinoma risk in a Chinese population. Tumor Biol. 35, 3415–3419 (2014). https://doi.org/10.1007/s13277-013-1451-2

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  • DOI: https://doi.org/10.1007/s13277-013-1451-2

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