Tumor Biology

, Volume 33, Issue 1, pp 121–129

CD15+/CD16low human granulocytes from terminal cancer patients: granulocytic myeloid-derived suppressor cells that have suppressive function

Authors

  • Jahyang Choi
    • Cancer Research InstituteSeoul National University College of Medicine and Hospital
    • Innovative Research Institute for Cell TherapySeoul National University College of Medicine and Hospital
  • Beomseok Suh
    • Cancer Research InstituteSeoul National University College of Medicine and Hospital
  • Yong-Oon Ahn
    • Cancer Research InstituteSeoul National University College of Medicine and Hospital
    • Innovative Research Institute for Cell TherapySeoul National University College of Medicine and Hospital
  • Tae Min Kim
    • Cancer Research InstituteSeoul National University College of Medicine and Hospital
    • Innovative Research Institute for Cell TherapySeoul National University College of Medicine and Hospital
    • Department of Internal MedicineSeoul National University College of Medicine and Hospital
  • Jeong-Ok Lee
    • Cancer Research InstituteSeoul National University College of Medicine and Hospital
    • Department of Internal MedicineSeoul National University College of Medicine and Hospital
  • Se-Hoon Lee
    • Cancer Research InstituteSeoul National University College of Medicine and Hospital
    • Innovative Research Institute for Cell TherapySeoul National University College of Medicine and Hospital
    • Department of Internal MedicineSeoul National University College of Medicine and Hospital
    • Cancer Research InstituteSeoul National University College of Medicine and Hospital
    • Innovative Research Institute for Cell TherapySeoul National University College of Medicine and Hospital
    • Department of Internal MedicineSeoul National University College of Medicine and Hospital
Research Article

DOI: 10.1007/s13277-011-0254-6

Cite this article as:
Choi, J., Suh, B., Ahn, Y. et al. Tumor Biol. (2012) 33: 121. doi:10.1007/s13277-011-0254-6

Abstract

Myeloid-derived suppressor cells (MDSCs) are a subpopulation of myeloid cells with immunosuppressive function whose numbers are increased in conditions such as chronic infection, trauma, and cancer. Unlike murine MDSCs defined as CD11b+/Gr-1+, there are no specific markers for human MDSCs. The goal of this study was to delineate a specific human MDSCs subpopulation in granulocytes from terminal cancer patients and investigate its clinical implications. Here, we show that the CD15+/CD16low subset was increased in terminal cancer patients compared with healthy donors (P = 0.009). Phorbol 12-myristate 13-acetate-activated granulocytes (CD16low/CD66b++/CD15+) that have a phenotype similar to MDSCs from cancer patients, effectively suppressed both proliferation and cytotoxicity of normal T cells. Among cancer patients, T-cell proliferation was highly suppressed by granulocytes isolated from terminal cancer patients with a high proportion of CD15+/CD16low cells. Patients with low peripheral blood levels of CD15+/CD16low cells had significantly longer survival than those with high levels (P = 0.0011). Patients with higher levels of CD15+/CD16low also tended to have poor performance status (P = 0.05). These data suggest that CD15+/CD16low granulocytes found in terminal cancer patients may play a role in the progression of cancer by inhibiting tumor immunity.

Keywords

MDSCs CD15+/CD16low granulocytes T-cell suppression Tumor immunity Immune monitoring

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2011