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Associations of MMP-2 −1306 C/T and MMP-9 −1562 C/T polymorphisms with breast cancer risk among different populations: a meta-analysis

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Abstract

The meta-analysis aims to investigate association between two matrix metalloproteinases (MMPs) polymorphisms (MMP-2 −1306 C/T and MMP-9 −1562 C/T) and breast cancer risk. Eligible studies were retrieved from relevant databases, based on predefined criteria. Quality assessment was evaluated by Newcastle–Ottawa Scale. Odds ratio (OR) with its 95% confidence interval (CI) was selected as the effect size for the meta-analysis. As a result, 13 studies were included. MMP-2 −1306 C/T polymorphism was not significantly associated with breast cancer risk under all genetic models (P > 0.05). However, subgroup analysis stratified by ethnicity showed a significant association between MMP-2 −1306 C/T polymorphism and reduced breast cancer risk in Asian populations under allelic model (OR 0.60, 95% CI 0.39–0.90, P = 0.02) and dominant model (OR 0.55, 95% CI 0.34–0.89, P = 0.02). MMP-9 −1562 C/T polymorphism was significantly related to increased breast cancer risk under allelic model (OR 1.50, 95% CI 1.06–2.12, P = 0.02), additive model (OR 1.45, 95% CI 1.02–2.05, P = 0.04) and recessive model (OR 1.54, 95% CI 1.13–2.12, OR 0.007). A significant association between MMP-9 −1562 C/T polymorphism and increased breast cancer risk in Caucasian was detected under most of the genetic models (P < 0.05). MMP-2 −1306 C/T polymorphism might be significantly associated with reduced breast cancer risk in Asian, while MMP-9 −1562 C/T might be closely related to increased breast cancer risk, especially in Caucasian.

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Authors and Affiliations

  1. Department of Breast Surgery, The First Hospital of Qinhuangdao, No. 258, Wenhua Road, Haigang District, Qinhuangdao, 066000, Hebei, China

    Meng Han, Qingfeng Yang, Kai Feng, Rongping Li, Jia Ren & Liguang Wei

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  1. Meng Han
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  2. Qingfeng Yang
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  3. Kai Feng
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  4. Rongping Li
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  5. Jia Ren
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  6. Liguang Wei
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Correspondence to Meng Han.

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Meng Han, Qingfeng Yang, Kai Feng, Rongping Li, Jia Ren, and Liguang Wei declares that they have no conflict of interest.

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In this study, no tissue or sample was obtained from human or animal. This study was compliant with ethical standards.

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Han, M., Yang, Q., Feng, K. et al. Associations of MMP-2 −1306 C/T and MMP-9 −1562 C/T polymorphisms with breast cancer risk among different populations: a meta-analysis. Genes Genom 39, 331–340 (2017). https://doi.org/10.1007/s13258-016-0498-z

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  • DOI: https://doi.org/10.1007/s13258-016-0498-z

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