Genes & Genomics

, Volume 35, Issue 4, pp 523–528

Porcine insulin-like growth factor 1 (IGF1) gene polymorphisms are associated with body size variation

  • Pengxia Niu
  • Sang-Wook Kim
  • Bong-Hwan Choi
  • Tae-Hun Kim
  • Jong-Joo Kim
  • Kwan-Suk Kim
Research Article

DOI: 10.1007/s13258-013-0098-0

Cite this article as:
Niu, P., Kim, SW., Choi, BH. et al. Genes Genom (2013) 35: 523. doi:10.1007/s13258-013-0098-0

Abstract

Previous studies have confirmed that insulin growth factor-1 (IGF1) plays important roles in growth and body size in humans and animals. However, whether single nucleotide polymorphisms (SNPs) within the IGF1 gene affects body size and growth in pigs has been unclear. We identified IGF1 SNPs among 5 pig breeds (Berkshire, Duroc, Landrace, Yorkshire and Korea Native Pig) and found that the G allele of SNP (c.G189A) was associated with higher body weight and was more predominant in western pig breeds, while the Korean Native Pig is the breed with the highest frequency of the A allele. Four haplotypes (–GA–, –GG–, –AG–, and –AA–) were constructed using the 2 identified SNPs. The GA haplotype was most frequently observed, except in the Berkshire breed. In addition, these SNPs and haplotypes were significantly associated with body size (final weight), average daily gain, and backfat thickness (P < 0.05) in 2 intercrossed F2 pig populations (KNP × YS F2 and KNP × LR F2). Furthermore, the major GA haplotype had a significant additive effect on body size and average daily gain. In conclusion, specific SNPs within the porcine IGF1 gene may contribute to the smaller body size and lower growth rate of Korea Native Pigs.

Keywords

Carcass trait Growth trait IGF1 Pig SNP 

Copyright information

© The Genetics Society of Korea 2013

Authors and Affiliations

  • Pengxia Niu
    • 1
  • Sang-Wook Kim
    • 1
  • Bong-Hwan Choi
    • 2
  • Tae-Hun Kim
    • 2
  • Jong-Joo Kim
    • 3
  • Kwan-Suk Kim
    • 1
  1. 1.Department of Animal ScienceChungbuk National UniversityCheongju-Si, ChungbukSouth Korea
  2. 2.Division of Animal Genomics and BioinformaticsNational Institute of Animal ScienceSuwonKorea
  3. 3.School of BiotechnologyYeungnam UniversityGyeongsanSouth Korea