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Transdermal Hydrogel Composed of Polyacrylic Acid Containing Propolis for Wound Healing in a Rat Model

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Abstract

The aim of this study was to investigate the effect of the Carbopol® hydrogel containing propolis (CHP) on wound healing in a rat model. CHP extracts inhibited nitric oxide production induced by lipopolysaccharide in RAW264.7 cells with a concentration-dependent manner. Wounds were prepared through excision to remove full-thickness skin of rats k]and then were covered with CHP. The covered wounds showed significantly rapid contraction and closure. Histological tissue examination indicated that CHP induced advanced granulation tissue formation and re-epithelialization in the wound. These results indicate that CHP may be helpful for the promotion of wound healing.

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Authors and Affiliations

  1. Department of Advanced Chemicals and Engineering, Chonnam National University, Gwangju, 61186, Korea

    Jin Kim

  2. Department of Biomedical Engineering, Chonnam National University, Yeosu, 59626, Korea

    Chang-Moon Lee

  3. Research Center of Healthcare Biomedical Engineering, Chonnam National University, Yeosu, 59626, Korea

    Jin Kim & Chang-Moon Lee

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  1. Jin Kim
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  2. Chang-Moon Lee
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Correspondence to Chang-Moon Lee.

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Acknowledgments: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2015R1C1A1A02036746 and 2017M2A2A7A0304183 2).

The image from this article is used as the cover image of the Volume 26, Issue 13.

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Kim, J., Lee, CM. Transdermal Hydrogel Composed of Polyacrylic Acid Containing Propolis for Wound Healing in a Rat Model. Macromol. Res. 26, 1219–1224 (2018). https://doi.org/10.1007/s13233-019-7014-7

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  • DOI: https://doi.org/10.1007/s13233-019-7014-7

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