Skip to main content
Log in

Adhesive heparin coating for marine antifouling applications

  • Articles
  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

The control of marine biofouling has gained significant attention because the uncontrolled adhesion of marine organisms onto synthetic surfaces leads to serious problems. Here, we demonstrate a facile method to inhibit the adhesion of marine organisms using the sulfated polysaccharide, heparin. Heparin was conjugated with an adhesive molecule, catechol, and the resulting adhesive heparin was used as a surface coating for stainless steel, a material commonly used for marine vessels. Immersion of stainless steel surfaces in a solution of adhesive heparin resulted in a stable heparin coating. The marine antifouling property of the surface was confirmed using marine diatom adhesion assays, which revealed that the adhesive heparin coating reduced diatom adhesion by ~75%, as compared with untreated surfaces.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. S. Noimark, C. W. Dunnill, M. Wilson, and I. P. Parkin, Chem. Soc. Rev., 38, 3435 (2009).

    Article  CAS  Google Scholar 

  2. E.-R. Kenawy, S. Worley, and R. Broughton, Biomacromolecules, 8, 1359 (2007).

    Article  CAS  Google Scholar 

  3. J. A. Callow and M. E. Callow, Nat. Commun., 2, 244 (2011).

    Article  Google Scholar 

  4. D. M. Yebra, S. Kiil, and K. Dam-Johansen, Prog. Org. Coat., 50, 75 (2004).

    Article  CAS  Google Scholar 

  5. J. M. Harris, Introduction to Biotechnical and Biomedical Applications of Poly(ethylene glycol), Springer, New York, 1992.

    Book  Google Scholar 

  6. W. K. Cho, S. M. Kang, and J. K. Lee, J. Nanosci. Nanotechnol., 14, 1231 (2014).

    Article  CAS  Google Scholar 

  7. S. Chen, L. Li, C. Zhao, and J. Zheng, Polymer, 51, 5283 (2010).

    Article  CAS  Google Scholar 

  8. J. Andersson, J. Sanchez, K. N. Ekdahl, G. Elgue, B. Nilsson, and R. Larsson, J. Biomed. Mater. Res. A, 67, 458 (2003).

    Article  Google Scholar 

  9. B. G. Bruinsma, Y. Kim, T. A. Berendsen, S. Ozer, M. L. Yarmush, and B. E. Uygun, J. Clin. Transl. Res., 1, 4 (2015).

    Google Scholar 

  10. C. Cheng, S. Sun, and C. Zhao, J. Mater. Chem. B, 2, 7649 (2014).

    Article  CAS  Google Scholar 

  11. H. Wei, L. Han, J. Ren, and L. Jia, ACS Appl. Mater. Interfaces, 5, 12571 (2013).

    Article  CAS  Google Scholar 

  12. B. Xie, C. Pan, H. Ding, and N. Huang, J. Wuhan Univ. Technol., 29, 832 (2014).

    Article  Google Scholar 

  13. Y. Yao, K. Fukazawa, W. Ma, K. Ishihara, and N. Huang, Appl. Surf. Sci., 258, 5418 (2012).

    Article  CAS  Google Scholar 

  14. P. H. van Bilsen, G. Krenning, D. Billy, J.-L. Duval, J. Huurdeman-Vincent, and M. J. van Luyn, Colloids Surf. B, 67, 46 (2008).

    Article  Google Scholar 

  15. I.-H. Bae, I.-K. Park, D. S. Park, H. Lee, and M. H. Jeong, J. Mater. Sci. Mater. Med., 23, 1259 (2012).

    Article  CAS  Google Scholar 

  16. I. You, S. M. Kang, Y. Byun, and H. Lee, Bioconjugate Chem., 22, 1264 (2011).

    Article  CAS  Google Scholar 

  17. B. P. Lee, P. B. Messersmith, J. N. Israelachvili, and J. H. Waite, Annu. Rev. Mater. Res., 41, 99 (2011).

    Article  CAS  Google Scholar 

  18. H. Lee, S. M. Dellatore, W. M. Miller, and P. B. Messersmith, Science, 318, 426 (2007).

    Article  CAS  Google Scholar 

  19. H. Lee, B. P. Lee, and P. B. Messersmith, Nature, 448, 338 (2007).

    Article  CAS  Google Scholar 

  20. H. Lee, N. F. Scherer, and P. B. Messersmith, Proc. Natl. Acad. Sci. U.S.A., 103, 12999 (2006).

    Article  CAS  Google Scholar 

  21. J. H. Waite and X. Qin, Biochemistry, 40, 2887 (2001).

    Article  CAS  Google Scholar 

  22. H. Lee, K. D. Lee, K. B. Pyo, S. Y. Park, and H. Lee, Langmuir, 26, 3790 (2010).

    Article  CAS  Google Scholar 

  23. H. Lee, Y. Lee, A. R. Statz, J. Rho, T. G. Park, and P. B. Messersmith, Adv. Mater., 20, 1619 (2008).

    Article  CAS  Google Scholar 

  24. I.-C. Sun, D.-K. Eun, J. H. Na, S. Lee, I.-J. Kim, I.-C. Youn, C.-Y. Ko, H.-S. Kim, D. Lim, and K. Choi, Chem. Eur. J., 15, 13341 (2009).

    Article  CAS  Google Scholar 

  25. M. Lee, Y. Kim, J. H. Ryu, K. Kim, Y.-M. Han, and H. Lee, Acta Biomater., 32, 138 (2016).

    Article  CAS  Google Scholar 

  26. T. G. Kim, H. Lee, Y. Jang, and T. G. Park, Biomacromolecules, 10, 1532 (2009).

    Article  CAS  Google Scholar 

  27. L. D. Chambers, K. R. Stokes, F. C. Walsh, and R. J. K. Wood, Surf. Coat. Technol. 201, 3642 (2006).

    Article  CAS  Google Scholar 

  28. C. Hellio and D. M. Yebra, Advances in Marine Antifouling Coatings and Technologies, Elsevier, Cornwall, 2009.

    Book  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sung Min Kang.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kim, S., Ko, S. & Kang, S.M. Adhesive heparin coating for marine antifouling applications. Macromol. Res. 24, 645–649 (2016). https://doi.org/10.1007/s13233-016-4091-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13233-016-4091-8

Keywords

Navigation