Abstract
In this study, composites of polylactide (PLA) and hyaluronic acid-chitosan ionic complex (HACS) which are derived from hyaluronic acid (HA) and chitosan (CS), respectively, were prepared to investigate the enhancing effects of their mechanical properties, crystallinity, and biodegradation. To reach reasonable tensile modulus properties such as those in human bone, β-tricalcium phosphate (BCP) was added, which can prevent the stress shielding effect. The addition of reinforcements in the PLA matrix significantly increased the tensile strength and modulus of the PLA composites. To verify the effect of reinforcements on crystallinity behavior and surface morphology, we used differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) to examine dispersion properties. Moreover, an in vitro enzymatic biodegradation test on composites was carried out with esterase from porcine liver at 37 °C in PBS solution (pH 7.4).
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Chon, J.W., Jang, I.K., Suh, S.W. et al. Development of reinforced polylactide composite resin for micro surgery bone plate and screw. Macromol. Res. 24, 37–43 (2016). https://doi.org/10.1007/s13233-016-4003-y
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DOI: https://doi.org/10.1007/s13233-016-4003-y