Skip to main content
SpringerLink
Log in

Blood-compatible and biodegradable polymer-coated drug-eluting stent

  • Article
  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

A drug-eluting stent (DES) is a metal stent that has been coated with a drug known to suppress restenosis. To prepare a novel DES, a bare metal stent (BMS) was coated with sirolimus (SRL) in a blood-compatible, biodegradable polymer, poly lactic-glycolic acid, grafted with poly ethylene glycol (PLGA-PEG), by an ultrasonic spray method. The PLGA-PEG-coated DES was designed to control the drug release-rate by varying the PEG content in the polymer. The release behavior of SRL from the DES showed a burst-release pattern in 7 days and then sustained-release over 21 days. The amount of SRL released increased with increasing PEG content in the polymer up to 15%. The PLGA-PEG copolymer coated on the stent showed the potential to act as a bio-degradable drug reservoir. In an in vitro platelet adhesion test, the PLGA-PEG15-coated DES showed significantly reduced platelet deposition versus the BMS. The DES revealed anti-thrombotic activity and blood-compatibility presumably due to the increased hydrophilicity of the surface of the stent and the amount of SRL loading corresponding to the high PEG content in the polymer. In an animal study, the restenosis rate was reduced in the PLGA-PEG15-coated DES group (20.2±11.02%) versus the BMS group (44.2±12.11%). The PLGA-PEG15-coated DES inhibited smooth muscle cell (SMC) proliferation and prevented in-stent restenosis (ISR) in in vivo test. We successfully obtained the PLGA-PEG15-coated DES with smooth surface and sustained drug-release properties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. Betriu, M. Masotti, A. Serra, J. Alonso, F. Fernández-Avilés, F. Gimeno, T. Colman, J. Zueco, J. L. Delcan, and E. García, J. Am. Coll. Cardiol., 34, 1498 (1999).

    Article  CAS  Google Scholar 

  2. P. W. Serruys, P. Jaegere, F. Kiemeneij, C. Macaya, W. Rutsch, G. Heyndrickx, H. Emanuelsson, J. Marco, V. Legrand, and P. A. Materne, N. Engl. J. Med., 331, 489 (1994).

    Article  CAS  Google Scholar 

  3. C. K. Zarins, D. A. Bloch, T. Crabtree, A. H. Matsumoto, R. A. White, and T. J. Fogarty, J. Vascular. Surg., 38, 1264 (2003).

    Article  Google Scholar 

  4. A. Abizaid, R. Kornowski, G. S. Mintz, M. K. Hong, A. S. Abizaid, R. Mehran, A. D. Pichard, K. M. Kent, L. F. Satler, and H. Wu, J. Am. Coll. Cardiol., 32, 584 (1998).

    Article  CAS  Google Scholar 

  5. F. Alfonso, Eur. Cardiol. Rev., 5, 74 (2009).

    Article  Google Scholar 

  6. P. W. Serruys, M. J. Kutryk, and A. T. Ong, N. Engl. J. Med., 354, 483 (2006).

    Article  CAS  Google Scholar 

  7. M. N. Babapulle and M. J. Eisenberg, Circulation, 106, 2734 (2002).

    Article  Google Scholar 

  8. L. Räber and S. Windecker, Cardiovasc. Ther., 29, 176 (2011).

    Article  Google Scholar 

  9. P. Ted, D. Vipul, and F. Robert, Curr. Pharm. Des., 16, 3987 (2010).

    Google Scholar 

  10. A. V. Finn, M. Joner, G. Nakazawa, F. Kolodgie, J. Newell, M. C. John, H. K. Gold, and R. Virmani, Circulation, 115, 2435 (2007).

    Article  Google Scholar 

  11. S. Garg and P. W. Serruys, J. Am. Coll. Cardiol., 56, S1 (2010).

    Article  CAS  Google Scholar 

  12. G. Nakazawa, A. V. Finn, and R. Virmani, Herz, 32, 274 (2007).

    Article  Google Scholar 

  13. G. J. Wilson, G. Nakazawa, R. S. Schwartz, B. Huibregtse, B. Poff, T. J. Herbst, D. S. Baim, and R. Virmani, Circulation, 120, 141 (2009).

    Article  CAS  Google Scholar 

  14. S. J. Denardo, P. L. Carpinone, D. M. Vock, C. D. Batich, and C. J. Pepine, JAMA, 307, 2148 (2012).

    Article  CAS  Google Scholar 

  15. S. M. Tugtekin, U. Kappert, F. Jung, J. W. Park, and M. Knaut, Herz, 29, 201 (2004).

    Article  Google Scholar 

  16. C. Özbek, C. Mailänder, U. Schilling, and R. Bach, Clin. Hemorheol. Microcirc., 39, 311 (2008).

    Google Scholar 

  17. Y. Levy, D. Mandler, J. Weinberger, and A. J. Domb. J. Biomed. Mater. Res. B: Appl. Biomater, 91, 441 (2009).

    Article  Google Scholar 

  18. Y. Levy, N. Tal, G. Tzemach, J. Weinberger, A. J. Domb, D. Mandler, J. Biomed. Mater. Res. B: Appl. Biomater., 91, 819 (2009).

    Article  Google Scholar 

  19. T. Parker, V. Dave, and R. Falotico, Curr. Pharm. Des., 16, 3978 (2010).

    Article  CAS  Google Scholar 

  20. G. Sandhu, B. Doyle, R. Singh, M. Bell, J. Bresnahan, V. Mathew, D. Holmes, A. Lerman, and C. Rihal, Am. J. Cardiol., 99, 465 (2007).

    Article  CAS  Google Scholar 

  21. Y. Hong, S. H. Ye, A. L. Pelinescu, and W. R.Wagner, Biomacromolecules, 13, 3686 (2012).

    Article  CAS  Google Scholar 

  22. S. H. Ye, Y. S. Jang, Y. H. Yun, V. Shankarraman, J. R. Woolley, Y. Hong, L. J. Gamble, K. Ishihara, and W. R. Wagner, Langmuir, 29, 8320 (2013).

    Article  CAS  Google Scholar 

  23. X. Zhang, D. Tan, J. Li, H. Tan, and Q. Fu, Biofouling, 27, 919 (2011).

    Article  CAS  Google Scholar 

  24. J. M. Orban, T. M. Chapman, W. R. Wagner, and R. Jankowski, J. Polym. Sci. Part A: Polym. Chem., 37, 3441 (1999).

    Article  CAS  Google Scholar 

  25. J. Courtney, N. Lamba, S. Sundaram, and C. Forbes, Biomaterials, 15, 737 (1994).

    Article  CAS  Google Scholar 

  26. S. Jeon, J. Lee, J. Andrade, and P. De Gennes, J. Colloid Interface Sci., 142, 149 (1991).

    Article  CAS  Google Scholar 

  27. X. G. Zhang, D. Y. Teng, Z. M. Wu, X. Wang, Z. Wang, D. M. Yu, and C. X. Li, J. Mater. Sci. Mater. Med., 19, 3525 (2008).

    Article  CAS  Google Scholar 

  28. K. S. Lim, J. K. Park, M. H. Jeong, J. W. Nah, D. G. Kim, I. H. Bae, D. S. Park, J. M. Kim, J. H. Kim, D. L. Cho, D. S. Sim, and K. H. Park, Macromol. Res., 22, 639 (2014).

    Article  CAS  Google Scholar 

  29. J. Chen, Q. Li, J. Chen, C. Chen, and N. Huang, Appl. Surf. Sci., 255, 6894 (2009).

    Article  CAS  Google Scholar 

  30. I. H. Bae, I. K. Park, D. S. Park, H. Lee, and M. H. Jeong, J. Mater. Sci. Mater. Med., 23, 1259 (2012).

    Article  CAS  Google Scholar 

  31. X. Zhang, D. Tan, J. Li, H. Tan, and Q. Fu, Biofouling, 27, 919 (2011).

    Article  CAS  Google Scholar 

  32. V. Farooq, B. D. Gogas, and P. W. Serruys, Circ. Cardiovas. Interv., 4, 195 (2011).

    Article  Google Scholar 

  33. V. Farooq, B. D. Gogas, and P. W. Serruys, Circ. Cardiovas. Interv., 4, 195 (2011).

    Article  Google Scholar 

  34. F. E. Bailey and J. V. Koleske, Poly(ethylene oxide), Academic Press, New York, 1976.

    Google Scholar 

  35. T. A. Fischell, D. Dishmon, A, Elhaddi, S, Alsafwah, and S. R. Mannem, Cardiac Interventions Today, 29–35 (2009).

    Google Scholar 

  36. G. Acharya and K. Park, Adv. Drug Deliv. Rev., 58, 387 (2006).

    Article  CAS  Google Scholar 

  37. E. Gultepe, D. Nagesha, S. Sridhar, and M. Amiji, Adv. Drug Deliv. Rev., 62, 305 (2010).

    Article  CAS  Google Scholar 

  38. V. Karagkiozaki, E. Vavoulidis, P. G. Karagiannidis, M. Gioti, D. G. Fatouros, I. S. Vizirianakis, and S. Logothetidis, Int. J. Nanomedicine, 7, 5327 (2012).

    CAS  Google Scholar 

  39. L. Lu, C. A. Garcia, and A. G. Mikos, J. Biomed. Mater. Res., 46, 236 (1999).

    Article  CAS  Google Scholar 

  40. X. Wang, S. S. Venkatraman, F. Y. Boey, J. S. Loo, and L. P. Tan, Biomaterials, 27, 5588 (2006).

    Article  CAS  Google Scholar 

  41. Y. J. Kim, I. K. Kang, M. W. Huh, and S. C. Yoon, Biomaterials, 21, 121 (2000).

    Article  CAS  Google Scholar 

  42. I. H. Bae, I. K. Park, D. S. Park, H. Lee, and M. H. Jeong, J. Mater. Sci. Mater. Med., 23, 1259 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Polymer Science and Engineering, Sunchon National University, 255 Jungang-ro, Sunchon, Jeonnam, 540-742, Korea

    Jun-kyu Park, Dong-Gon Kim, Changyong Choi & Jae-Woon Nah

  2. Chonnam National University Research Institute of Medical Science, 42 Jebong-ro Donggu, Gwangju, 501-757, Korea

    In Ho Bae, Kyung Seob Lim & Myung Ho Jeong

  3. Korea Cardiovascular Stent Institute of Chonnam National University, Gwangju, 501-757, Korea

    In Ho Bae, Kyung Seob Lim & Myung Ho Jeong

  4. Department of Chemical and Biochemical Engineering, Chosun University, Gwangju, 501-759, Korea

    Soo-Kyung Choi

  5. Department of Environmental Education, Mokpo National University, 1666 Youngsan Ro, Cheonggye Myeon, Muan, Jeonnam, 534-729, Korea

    Sang Chai Kim

Authors
  1. Jun-kyu Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dong-Gon Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. In Ho Bae
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kyung Seob Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Myung Ho Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Changyong Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Soo-Kyung Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sang Chai Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Jae-Woon Nah
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jae-Woon Nah.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Park, Jk., Kim, DG., Bae, I.H. et al. Blood-compatible and biodegradable polymer-coated drug-eluting stent. Macromol. Res. 23, 237–244 (2015). https://doi.org/10.1007/s13233-015-3023-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13233-015-3023-3

Keywords

Search

Navigation