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Comparison of Sequential Organ Failure Assessment (SOFA) and Sepsis in Obstetrics Score (SOS) in Women with Pregnancy-Associated Sepsis with Respect to Critical Care Admission and Mortality: A Prospective Observational Study

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Abstract

Objective

We aimed to determine performance of sequential organ failure assessment (SOFA) and Sepsis in Obstetrics Score (SOS), in women with pregnancy-associated sepsis (PAS) with respect to critical care admission and mortality.

Methods

Obstetric patients with PAS fulfilling any 2 of the quick SOFA (qSOFA) criteria were enrolled as cases. The various parameters of SOFA and SOS were recorded at admission and compared for outcomes.

Results

Critical care was required in 32 (50.7%) patients and associated mortality was high (31.7%). For our study population, a threshold of SOFA ≥ 6 had the best combination of sensitivity (84.4%) and specificity (61.3%) for critical care admission. For SOS, a cut-off value of ≥ 6 gave best sensitivity (64%) and specificity (40%) for the same.

Conclusions

SOFA was far more predictive of patient's critical condition as well as mortality compared to SOS. SOFA was superior to SOS in determining critical care admission and mortality for PAS.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, 110095, India

    Rachna Agarwal & Penzy Goyal

  2. Department of Anaesthesia, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, 110095, India

    Medha Mohta

  3. Department of Biochemistry, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, 110095, India

    Rajarshi Kar

Authors
  1. Rachna Agarwal
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  2. Penzy Goyal
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  4. Rajarshi Kar
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Correspondence to Rachna Agarwal.

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Conflict of interest

The authors declare that they have no conflict of interest.

Consent for Publication

The work submitted has not been published before; that it is not under consideration for publication anywhere else; that its publication has been approved by all co-authors, if any, as well as by the responsible authorities and at the institute where the work has been carried out.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Ethical Clearance

Institutional Ethical committee, University College of Medical Sciences, Delhi-110031 dated 17 October 2017.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Dr. Rachna Agarwal, MS (Obstetrics & Gynaecology) is Professor at Department of Obstetrics & Gynaecology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India; Dr. Penzy Goyal, MBBS is Postgraduate student at Department of Obstetrics & Gynaecology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India; Dr. Medha Mohta, MD (Anaesthesia) is Director Professor at Department of Anaesthesia, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India; Dr. Rajarshi Kar, MD (Biochemistry) is Associate Professor, Department of Biochemistry, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.

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Agarwal, R., Goyal, P., Mohta, M. et al. Comparison of Sequential Organ Failure Assessment (SOFA) and Sepsis in Obstetrics Score (SOS) in Women with Pregnancy-Associated Sepsis with Respect to Critical Care Admission and Mortality: A Prospective Observational Study. J Obstet Gynecol India 71, 45–51 (2021). https://doi.org/10.1007/s13224-020-01375-9

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  • DOI: https://doi.org/10.1007/s13224-020-01375-9

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