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Comparative Study of Efficacy and Safety of Ferric Carboxymaltose Versus Iron Sucrose in Post-partum Anaemia

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Abstract

Background

The incidence of post-partum anaemia (PPA) is 14–24%. Treatment of PPA with injectable iron replenishes the iron store. Ferric carboxymaltose complex (FCM) is a non-dextran containing intravenous iron agent, having a very low immunogenic potential, designed to be administered in large doses in a short period of time.

Objective

To compare the efficacy and safety of intravenous FCM and iron sucrose (IS) in post-partum iron-deficiency anaemia.

Material and Method

In this prospective, comparative study, 120 post-partum women with iron-deficiency anaemia (Hb < 10 g%) were divided into two groups. A fixed dose of 1000 mg of FCM or IS was given within 10 days of delivery. Hb and serum ferritin were repeated 14 days post-transfusion.

Result

There is a mean increase in Hb (P value 0.000, 0.000) and ferritin (P value 0.000, 0.000) in both the groups. For intergroup comparison, independent Student’s t test was performed which showed FCM was superior to IS (P value 0.000 and 0.000).

Conclusion

In our study, FCM was very effective in improving Hb concentration as well as in early replenishment of iron stores in patients with PPA. Large doses given in a short period of time not only save hospital resources but also improve patient satisfaction. It has significant benefit for use in the outpatient department. From this study, we can recommend its use in post-partum women with iron-deficiency anaemia.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, B 1 D, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, 793018, India

    Nalini Sharma, J. Lalnunnem Thiek & Santa Singh Ahanthem

  2. Department of Ophthalmology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India

    Tanie Natung

Authors
  1. Nalini Sharma
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  2. J. Lalnunnem Thiek
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  3. Tanie Natung
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  4. Santa Singh Ahanthem
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Corresponding author

Correspondence to Nalini Sharma.

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Conflict of interest

Nalini Sharma, Tanie Natung, J Lalnunnen Thiek, Santa Singh Ahanthem declare that they have no conflict of interest.

Ethical Approval

Institutional ethical committee clearance was obtained for study.

Informed Consent

Informed consent was obtained from all patients for being included in study.

Additional information

Nalini Sharma is an Assistant Professor at Department of Obstetrics and Gynaecology, North-eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India; Lalnunnem Thiek is a Senior resident at Department of Obstetrics and Gynaecology, North-eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India; Tanie Natung is an Assistant Professor at Department of Ophthalmology, North-eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India; Santa Singh Ahanthem is a DNB Professor and head at Department of Obstetrics and Gynaecology, North-eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

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Sharma, N., Thiek, J.L., Natung, T. et al. Comparative Study of Efficacy and Safety of Ferric Carboxymaltose Versus Iron Sucrose in Post-partum Anaemia. J Obstet Gynecol India 67, 253–257 (2017). https://doi.org/10.1007/s13224-017-0971-x

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  • DOI: https://doi.org/10.1007/s13224-017-0971-x

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