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Gonadotropin Alone is a Better Drug for Ovarian Stimulation than in Combination with Clomiphene in Intrauterine Insemination

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Abstract

Objective

This study compares the efficacy of sequential clomiphene citrate (CC) + Gonadotropin to that of Gonadotropin alone with ultrasound monitoring.

Methods

It is a retrospective analytic study done on a total of 100 couples to compare two groups receiving CC + Gonadotropin and Gonadotropin alone for ovarian stimulation followed by intrauterine Insemination (IUI). We studied the cycle performance parameters. Cumulative pregnancy rates and ovulation rates were the primary outcomes. Results were analyzed following the intention-to-treat principle.

Results

There were no significant differences with respect to indications and the numbers of dominant follicles recruited. The endometrial thickness was significantly better in Gonadotropin-alone group (P < 0.05). Ovulation rate was better for CC + Gonadotropin at 95.91 %. Nine pregnancies were in the CC + Gonadotropin group (18.36 %) and 17 in Gonadotropin-alone group (33.3 %).

Conclusions

Significant differences in pregnancy rates and endometrial thickness were seen. Gonadotropin alone thus appears to give better results, but CC + Gonadotropin seems to be a cost-effective drug.

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Acknowledgments

The authors thank the nursing and secretarial staff at the Indraprastha Apollo Hospital’s IVF unit for their assistance in the preparation of this manuscript.

Compliance with ethical requirements and Conflict of interest

Our study is retrospective data analysis as per ethics with consent of using stored data from treating doctor and hospital authority. The study is designed with an intension to treat patient and to find out which method is better for ovarian stimulation. There are no conflicts of interests that I should disclose, having read the instructions of submission and policies of journal.

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Authors and Affiliations

  1. Indraprastha Apollo Hospitals, Institute of Obstetrics and Gynaecology, New Delhi, India

    Sushma Sinha (Senior Consultant Obstetrician Gynaecologist, Infertility & IVF Specialist) & Neha Agrawal (Senior Resident)

  2. 416 Goyal Nagar, Near Jain Temple, Bengali Square, Indore, 452018, Madhya Pradesh, India

    Neha Agrawal (Senior Resident)

Authors
  1. Sushma Sinha
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  2. Neha Agrawal
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Correspondence to Neha Agrawal.

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Sinha, S., Agrawal, N. Gonadotropin Alone is a Better Drug for Ovarian Stimulation than in Combination with Clomiphene in Intrauterine Insemination. J Obstet Gynecol India 66, 333–338 (2016). https://doi.org/10.1007/s13224-015-0686-9

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  • DOI: https://doi.org/10.1007/s13224-015-0686-9

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