Abstract
Antimicrobial peptides (AMPs) are diverse group of natural proteins present in animals, plants, insects and bacteria. These peptides are responsible for defense of host from pathogenic organisms. Chemical, enzymatic and recombinant techniques are used for the synthesis of antimicrobial peptides. These peptides have been found to be an alternative to the chemical preservatives. Currently, nisin is the only antimicrobial peptide, which is widely utilized in the preservation of food. Antimicrobial peptides can be used alone or in combination with other antimicrobial, essential oils and polymeric nanoparticles to enhance the shelf-life of food. This review presents an overview on different types of antimicrobial peptides, purification techniques, mode of action and application in food preservation.
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References
Abdelbasset M, Djamila K (2008) Antimicrobial activity of autochthonous lactic aicd bacteria isolated from Algerian traditional fermented milk “Raib”. Afr J Biotechnol 7(16):2908–2914
Abraham P, George S, Santhosh K (2014) Novel antibacterial peptides from the skin secretion of the Indian bicoloured frog Clinotarsus curtipes. Biochimie 97:144–151
D’Amato D, Sinigaglia M (2010) Antimicrobial agents of microbial origin : Nisin. In: Bevilacqua A, Rosaria M, Sinigaglia M (Ed) Application of alternative food-preservation technologies to enhance food safety and stability, 1st edn. Bentham Science, USA, pp. 83–91
Bagley CP (2014) Potential role of synthetic AMPs in animal health to combat growing concerns of antibiotic resistance—a review. Wyno Acad J Agri Sci 2(2):19–28
Bahar AA, Ren D (2013) Antimicrobial peptides. Pharmaceuticals 6:1543–1575
Bala P, Kumar J (2014) Antimicrobial peptides: a review. Int J Life Sci Biotechnol Pharm Res 3(1):61–71
Balciunas EM, Martinez FC, Todorov SD, de Melo Franco BG, Converti A, de Souza Oliveira RP (2013) Novel biotechnological applications of bacteriocins: a review. Food Control 32:134–142
Barany G, Merrifield R (1980) The peptides: analysis, synthesis and biology. Academic Press, New York
Berglund N, Piggot T, Jefferies D, Sessions R, Bond P, Khalid S (2015) Interaction of the antimicrobial peptide polymyxin b1 with both membranes of E.coli: a molecular dynamics study. PLoS Comput Biol. doi:10.1371/journal.pcbi.1004180
Bezares BR, Saenz Beatriz Y, Zarazaga M, Torres C, Larrea RZ (2007) Antimicrobial activity of nisin against Oenococcus oeni and other wine bacteria. Int J Food Microbiol 116:32–36
Biswas A, Banerjee R (2016) A lab originated bacteriocin and its partial purification and demonstration of antimicrobial activity. Int J Curr Microbiol App Sci 5(3):728–737
Bolintineanu DS, Kaznessism YN (2011) Computational studies of protegrin antimicrobial peptide: a review. Peptides 32:188–201
Brogden KA, Ackermann M, Huttner KM (1997) Small, anionic, and charge-neutralizing propeptide fragments of zymogens are antimicrobial. Int J Antimicro Agents 1:1615–1617
Carneiro VA, Duarte HS, Prado MG, Silva ML, Teixeira M, dos Santos YM, Vasconcelos IB, Cunha RMS (2015) Antimicrobial peptides: from synthesis to clinical perspectives. In: Méndez-Vilas A (ed) The battle against microbial pathogens: basic science, technological advances and educational programs, 1st edn. Formatex Research Center, Spain, pp 81–90
Chen F, Zhang F, Wang A, Li H, Wang Q, Zeng Z, Wang S, Xi T (2010) Recent progress in the chemo-enzymatic peptide synthesis. Afr J Pharm Pharmacol 4(10):721–730
Chopra L, Singh G, Choudhary V, Sahoo DK (2014) Sonorensin: an antimicrobial peptide belonging to the heterocycloanthracin subfamily of bacteriocins, from a new marine isolate, Bacillus sonorensis MT93. Appl Environ Microbiol 80:2981–2990
Colins T, Mant CT, Ya Z, Mant CT, Yan Z, Popa TV, Kovacs JM, Mills JB, Tripet BP, Hodges RS (2012) HPLC analysis and purification of peptides. Method Mol Biol 386:3–55
Conde R, Arguello M, Izquierdo J, Noguez R, Moreno M, Lanz H (2012) Natural antimicrobial peptides from eukaryotic organisms. In: Bobbaraola V (ed) Antimicrobial agents. InTech, Croatia, pp 52–72
Cruz J, Ortiz C, Guzmán F, Fernández-Lafuente R, Torres R (2014) Antimicrobial peptides: promising compounds against pathogenic microorganisms. Curr Med Chem 21:1–23
De Zoysa GH, Cameron AJ, Hegde VV, Raghothama S, Sarojini V (2015) Antimicrobial peptide with potential for biofilm eradication: synthesis and structure activity relationship studies of battacin peptides. J Med Chem 58:625–639
Elayaraja S, Annamalai N, Mayavu P, Balasubramanian T (2014) Production, purification and characterization of bacteriocin from Lactobacillus murinus AU06 and its broad antibacterial spectrum. Asian Pac J Trop Biomed 4:305–311
Espitia PP, Soares NF, Coimbra JS, De Andrade NJ, Renatom SC, Medeiros E (2012) Bioactive peptides: synthesis, properties, and applications in the packaging and preservation of food. Compr Rev Food Sci Food Saf 11:187–204
Etchegaray A, Machini MT (2013) Antimicrobial lipopeptides: in vivo and in vitro synthesis. In: Mendez-vilas A (ed) Microbial pathogens and strategies for combating them, science, technology and education. Extremadura, Formatex, pp 951–959
Fadaei V (2012) Milk Proteins-derived antibacterial peptides as novel functional food ingredients. Ann Biol Res 3(5):2520–2526
Fernandez de Caleya R, Gonzalez-Pascual B, Garcia OF, Carbonero P (1972) Susceptibility of phytopathogenic bacteria to wheat purothionins in vitro. Appl Microbiol 23:998–1000
Fleming A (1922) On a remarkable bacteriolytic element found in tissues and secretions. Proc Royals Lon 93:306–317
Galvez AM, Grande Burges MJ, Lucas Loper R, Perez Pulido R (2014) Natural antimicrobials for food preservation. In: Galvez A, GrandeBurgos MJ, Lucas Lopez R, Perez Pulido R (eds) Food biopreservation. Springer, New York, pp 1–14. doi: 10.1007/978-1-4939-2029-7_2
Ganz T, Selsted ME, Szklarek D, Harwig SL, Daher K, Bainton DF, Lehre RI (1985) Defensins—natural peptide antibiotics of humanneutrophils. J Clin Invest 76:427–1435
Gause GF, Brazhnikova MG (1944) Gramicidin S and its use in the treatment of infected wounds. Nature 54:703
Gazil E, Miller IR, Biggin PC, Sansom MS, Shai Y (1996) Structure and orientation of the mammalian antibacterial peptide cecropin P1 within phospholipid membranes. J Mol Biol 258:860–870
Groves ML, Peterson RF, Kiddy CA (1965) Polymorphism in the red protein isolated from milk of individual cows. Nature 207:1007–1008
Guilhelmelli F, Nathalia V, Albuquerque P, Deremgowksi LS, Ildinete SP, Kyaw CM (2013) Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance. Front Microbiol. doi:10.3389/fmicb.2013.00353
Harris F, Dennison S, Phoenix DA (2009) Anionic antimicrobial peptide from eukaryotic organisms. Curr Protein Pept Sci 10(6):585–606
Hintz T, Matthews KK, Di R (2015) The use of plant antimicrobial compounds for food preservation. Bio Med Res Int. doi:10.1155/2015/246264
Hotchkiss RD, Dubos RJ (1940) Fractionation of the bactericidal agent from cultures of a soil Bacillus. Curr Prot Pept Sci 132:791–792
Jabeen U, Khanum A (2014) Isolation and characterization of potential food preservative peptide from Momordica charantia. L. Arabian J Chem doi:10.1016/j.arabjc.2014.06.009
Kraszewska J, Beckett MC, James TC, Bond U (2016) Comparative analysis of the antimicrobial activities of plant defensin-like and ultrashort peptides against food-spoiling bacteria. Appl Environ Microbiol. doi:10.1128/AEM.00558-16
Ludtke SJ, He K, Heller WT, Harroun TA, Yang L, Huang HW (1996) Membrane pores induced by magainin. Biochem 35:13723–13728
Mak AS, Jones BL (1976) Amino acid sequence of wheat betapurothionin. Can J Biochem 54:835–842
Mangalassary S, Han I, Rieck J, Acton J, Jiang X, Sheldon B, Dawson P (2007) Effect of combining nisin and/or lysozyme with in-package pasteurization on thermal inactivation of Listeria monocytogenes in ready-to-eat turkey bologna. J Food Prot 70:2503–2511
Meza J, Zarzosa A, Corona J, Bideshi D (2015) AMPs: current and potential applications in biomedical therapies. Biomed Res Int. doi:10.1155/2015/367243
Mills S, Stanton C, Hill C, Ross RP (2011) New developments and applications of bacteriocins and peptides in foods. Ann Rev Food Sci Technol 2:299–329
Mohanty D, Jena R, Choudhury PK, Pattnaik R, Mohapatra S, Saini MR (2016) Milk derived antimicrobial bioactive peptides: a review. Int J Food Prop 19:837–846
Ohtani S, Okada T, Yoshizumi H, Kagamiyama H (1977) Complete primary structures of 2 subunits of purothionin-A, a lethal protein for brewers yeast from wheat flour. J Biochem 82:753–767
Oyinloye BE, Adenow AF, Kappo AP (2015) Reactive oxygen species, apoptosis, amps and human inflammatory diseases. Pharmaceuticals 8:151–175
Pasupuleti M, Schmidtchen A, Malmsten M (2012) Antimicrobial peptides: key components of the innate immune system. Crit Rev Biotechnol 32:143–171
Pelegrini PB, del Sarto RP, Silva ON, Franco OL, Grossi-de-Sa MF (2011) Antibacterial peptides from plants: what they are and how they probably work. Biochem Res Int. doi:10.1155/2011/250349
Peravali JB, Kotra SR, Sobha K, Nelson R, Rajesh KV, Pulicherla KK (2013) AMPs: an effective alternative for antibiotic therapy. Mintage J Pharma Med Sci 2(2):1–7
Prombutara P, Kulwatthanasal Y, Supaka N, Sramala I, Chareonpornwattana S (2012) Production of nisin-loaded solid lipid nanoparticles for sustained antimicrobial activity. Food Control 24:184–190
Rea MC, Ross RP, Cotter PD, Hill C (2011) Classification of bacteriocins from Gram-positive bacteria. In Drider D, Rebuffat S (eds) Prokaryotic antimicrobial peptides: from genes to application, 1st edn. Springer, New York, pp. 29–47
Ribeiro A, Carrasco L (2014) Novel formulations for antimicrobial peptides. Int J Mol Sci 15:18040–18083
Riedl S, Zweytick D, Lohner K (2011) Membrane-active host defense peptides challenges and perspectives for the development of novel anticancer drugs. Chem Phys Lipids 164:766–781
Saeed AEA, Zubeir EM, Owni OAO (2009) Antimicrobial resistance of bacteria associated with raw milk contaminated by chemical preservatives. World J Dairy Food Sci 4(1):65–69
Salton MRJ (1958) The lysis of micro-organisms by lysozyme and related enzymes. J Gen Microbiol 18:481–490
Sankar R, Deepthi N, Priyanka V, Srinivas Reddy P, Rajanikanth P, Kumar VK, Indira M (2012) Purification and characterization of bacteriocin produced by Lactobacillus plantarum isolated from cow milk. Int J Microbiol Res 3(2):133–137
Scocchi M, Mardirossian M, Runti G, Benincasa M (2016) Non-membrane permeabilizing modes of action of antimicrobial peptides on bacteria. Curr Top Med Chem 16(1):76–88
Settanni L, Corsetti A (2008) Application of bacteriocins in vegetable food biopreservation. Int J Food Microbiol 121:123–138
Sewald N, Jakubke H (2002) Peptides: chemistry and biology. Wiley-VCH Verlag GmbH, Weinheim
So JE, Kang SH, Kim BG (1998) Lipase-catalyzed synthesis of peptides containing D-amino acid: facts and artifacts. Enzyme Microb Technol 23(3):211–215
Solomakos N, Govaris A, Koidis P, Botsoglou N (2008) The antimicrobial effect of thyme essential oil, nisin and their combination against Escherichia coli O157:H7 in minced beef during refrigerated storage. Meat Sci 80(1):159–166
Song H, Zheng W (2015) Antimicrobial natural products The battle against microbial pathogens: basic science, technological advances and educational programs In: Méndez-Vilas A (ed) The battle against microbial pathogens: basic science, technological advances and educational programs, 1st edn. Formatex Research Center, Spain, pp 49-58
Song DF, Zhu MY, Gu Q (2014) Purification and characterization of plantaricin zj5, a new bacteriocin produced by Lactobacillus plantarum ZJ5. PLoS One 9(8):1–8
Stephens JM, Marshall J (1962) Some properties of an immune factor isolated from the blood of actively immunised wax moth larvae. Can J Microbiol 8:719–725
Strempel N, Strehmel Overhag J (2015) Potential application of antimicrobial peptide in the treatment of bacterial biofilm infections. Curr Pharma Des 21:67–84
Suganthi V, Selvaranjan E, Subathradevi C, Mohansrinivasan V (2012) Lantibiotic nisin: natural preservative from Lactococcus lactis. Int J Res Pharma 3(1):13–19
Sumi CD, Yang BW, Yeo IC, Hahm YT (2015) Antimicrobial peptides of the genus Bacillus: a new era for antibiotics. Can J Microbiol 61:93–103
Tiwari BK, Valdramidis VP, O’Donnell CP (2009) Application of natural antimicrobials for food preservation. J Agric Food Chem. doi:10.1021/jf900668
Upendra RS, Khandelwal P, Jana K, Ajay Kumar N, Gayathri Devi M, Stephaney ML (2016) Bacteriocin production from indigenous strains of lactic acid bacteria isolated from selected fermented food sources. Int J Pharma Res Health Sci 4(1):982–990
Vocadlo DJ, Davies GJ, Laine R, Withers SG (2001) Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate. Nature 412:835–838
Wang Q, Zhu F, Xin Y, Liu J, Luo L, Yin Z (2011) Expression and purification of antimicrobial peptides buforin IIb in Escherichia coli. Biotechnol Lett 33:2121–2126
Wang S, Zeng X, Yang Q, Qiao S (2016) Antimicrobial peptides as potential alternatives to antibiotics in food animal industry. Int J Mol Sci 17(603):1–12
Zaffiri L, Gardner J, Toledo PH (2012) History of antibiotics from salvarsan to cephalosporins. J Invest Surg 25:67–77
Zhao R, Duan G, Yang T, Niu S, Wang Y (2015) Purification, characterization and antibacterial mechanism of bacteriocin from Lactobacillus Acidophilus XH1. Trop J Pharm Res 14(6):989–995
Zohri M, Alavidjeh M, Mirdamadi S, Nasr H, Ardestani S, Arabzadeh A (2013) Nisin loaded chitosan/alginate nanoparticles: a hopeful hybrid biopreservative. J Food Safety 3:40–49
Acknowledgments
The authors acknowledge financial support from Department of Science and Technology for providing INSPIRE Fellowship and UGC, New Delhi for financial assistance under SAP program. The authors would like to thank the financial support rendered by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Processo: 300127/2015-4; 150745/2015-0), Brazil.
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Rai, M., Pandit, R., Gaikwad, S. et al. Antimicrobial peptides as natural bio-preservative to enhance the shelf-life of food. J Food Sci Technol 53, 3381–3394 (2016). https://doi.org/10.1007/s13197-016-2318-5
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DOI: https://doi.org/10.1007/s13197-016-2318-5