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Antibacterial paperboard packaging using microfibrillated cellulose

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Abstract

The industry and consumers are focusing more and more on the development of biodegradable and lightweight food-packaging materials, which could better preserve the quality of the food and improve its shelf-life. In an attempt to meet these requirements, this study presents a novel bio-substrate able to contain active bio-molecules for future food-packaging applications. Based on a paperboard substrate, the development of an antibacterial bio-packaging material is, therein, achieved using a chlorhexidine digluconate (CHX) solution as a model of an antibacterial molecule, mixed with microfibrillated cellulose (MFC) and used as coating onto paperboard samples. AFM and FE-SEM analyses were performed to underline the nanoporous MFC network able to trap and to progressively release the CHX molecules. The release study of CHX was conducted in an aqueous medium and showed a lower proportion (20 %) of CHX released when using MFC. This led to the constant release of low amounts of CHX over 40 h. Antibacterial tests were carried out to assess the preservation of the antibacterial activity of the samples after the release studies. Samples remained active against Bacillus subtilis, with better results being obtained when MFC was used. The preservation of the quality of a model food was finally evaluated paving the way for future promising applications in the food packaging industry.

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References

  • Ben Arfa A, Preziosi-Belloy L, Chalier P, Gontard N (2007) Antimicrobial paper based on a soy protein isolate or modified starch coating including carvacrol and cinnamaldehyde. J Agric Food Chem 55:2155–2162

    Article  CAS  Google Scholar 

  • Cerisuelo JP, Muriel-Galet V, Bermádez JM, Aucejo S, Catalá RN, Gavara R, Hernández-Muñoz P (2012) Mathematical model to describe the release of an antimicrobial agent from an active package constituted by carvacrol in a hydrophilic EVOH coating on a PP film. J Food Eng 110:26–37

    Article  CAS  Google Scholar 

  • Cozzolino CA, Nilsson F, Iotti M, Sacchi B, Piga A, Farris S (2013) Exploiting the nano-sized features of microfibrillated cellulose (MFC) for the development of controlled-release packaging. Colloids Surf B 110:208–216

    Article  CAS  Google Scholar 

  • Dogan H, Koral M, İnan TY (2009) Ag/Zn zeolite containing antibacterial coating for food-packaging substrates. J Plast Films Sheet 25:207–220

    Article  CAS  Google Scholar 

  • European Parliament Council (2004) Regulation (EC) No 1935/2004 on materials and articles intended to come into contact with food and repealing directives 80/590/EEC and 89/109/EEC. Off J Eur Union L338:4–17

    Google Scholar 

  • Giménez-Martín E, López-Andrade M, Ontiveros-Ortega A, Espinosa-Jiménez M (2009) Adsorption of chlorhexidine onto cellulosic fibers. Cellulose 16:467–479

    Article  Google Scholar 

  • Guillard V, Issoupov V, Redl A, Gontard N (2009) Food preservative content reduction by controlling sorbic acid release from a superficial coating. Innov Food Sci Emerg Tech 10:108–115

    Article  CAS  Google Scholar 

  • Houston S, Hougland P, Anderson JJ, LaRocco M, Kennedy V, Gentry LO (2002) Effectiveness of 0.12 % chlorhexidine gluconate oral rinse in reducing prevalence of nosocomial pneumonia in patients undergoing heart surgery. Am J Crit Care 11:567–570

    Google Scholar 

  • Isogai A, Saito T, Fukuzumi H (2011) TEMPO-oxidized cellulose nanofibers. Nanoscale 3:71–85

    Article  CAS  Google Scholar 

  • Johansson C, Bras J, Mondragon I, Nechita P, Plackett D, Simon P, Svetec DG, Virtanen S, Baschetti MG, Breen C, Aucejo S (2012) Renewable fibers and bio-based materials for packaging applications—a review of recent developments. Bioresources 7:2506–2552

    Article  Google Scholar 

  • Khwaldia K, Arab-Tehrany E, Desobry S (2010) Biopolymer coatings on paper packaging materials. Compr Rev Food Sci Food 9:82–91

    Article  CAS  Google Scholar 

  • Kolakovic R, Peltonen L, Laaksonen T, Putkisto K, Laukkanen A, Hirvonen J (2011) Spray-dried cellulose nanofibers as novel tablet excipient. AAPS PharmSciTech 12:1366–1373

    Article  CAS  Google Scholar 

  • Kolakovic R, Laaksonen T, Peltonen L, Laukkanen A, Hirvonen J (2012a) Spray-dried nanofibrillar cellulose microparticles for sustained drug release. Int J Pharm 430:47–55

    Article  CAS  Google Scholar 

  • Kolakovic R, Peltonen L, Laukkanen A, Hirvonen J, Laaksonen T (2012b) Nanofibrillar cellulose films for controlled drug delivery. Eur J Pharm Biopharm 82:308–315

    Article  CAS  Google Scholar 

  • Korhonen JT, Kettunen M, Ras RHA, Ikkala O (2011) Hydrophobic nanocellulose aerogels as floating, sustainable, reusable, and recyclable oil absorbents. ACS Appl Mater Interfaces 3:1813–1816

    Article  CAS  Google Scholar 

  • Labuza TP, Breene WM (1989) Applications of “active packaging” for improvement of shelf-life and nutritional quality of fresh and extended shelf-life foods. J Food Process Pres 13:1–69

    Article  CAS  Google Scholar 

  • Lavoine N, Desloges I, Bras J (2014a) Microfibrillated cellulose coatings as new release systems for active packaging. Carbohydr Polym 103:528–537

    Article  CAS  Google Scholar 

  • Lavoine N, Bras J, Desloges I (2014b) Mechanical and barrier properties of cardboard and 3D packaging coated with microfibrillated cellulose. J Appl Polym Sci 131:40106–40117

    Article  Google Scholar 

  • Lavoine N, Desloges I, Sillard C, Bras J (2014c) Controlled release and long-term antibacterial activity of chlorhexidine digluconate through the nanoporous network of microfibrillated cellulose. Cellulose 21:4429–4442

    Article  CAS  Google Scholar 

  • Madene A, Jacquot M, Scher J, Desobry S (2006) Flavour encapsulation and controlled release—a review. Int J Food Sci Technol 41:1–21

    Article  CAS  Google Scholar 

  • Marrapese M (2013) Key considerations for successful technology transfer of nanocellulose. TAPPI International Conference on Nanotechnology Stockholm, Sweden

    Google Scholar 

  • Nassar MA, Youssef AM (2012) Mechanical and antibacterial properties of recycled carton paper coated by PS/Ag nanocomposites for packaging. Carbohydr Polym 89:269–274

    Article  CAS  Google Scholar 

  • Pääkkö M, Ankerfors M, Kosonen H, Nykänen A, Ahola S, Österberg M, Ruokolainen J, Laine J, Larsson PT, Ikkala O, Lindström T (2007) Enzymatic hydrolysis combined with mechanical shearing and high-pressure homogenization for nanoscale cellulose fibrils and strong gels. Biomacromolecules 8:1934–1941

    Article  Google Scholar 

  • Pereira de Abreu DA, Cruz JM, Paseiro Losada P (2012) Active and intelligent packaging for the food industry. Food Rev Int 28:146–187

    Article  CAS  Google Scholar 

  • Raso EMG, Cortes M, Teixeira K, Franco M, Mohallem N, Sinisterra R (2010) A new controlled release system of chlorhexidine and chlorhexidine:βCD inclusion compounds based on porous silica. J Incl Phenom Macrocycl 67:159–168

    Article  CAS  Google Scholar 

  • Ridgway C, Gane P (2012) Constructing NFC-pigment composite surface treatment for enhanced paper stiffness and surface properties. Cellulose 19:547–560

    Article  CAS  Google Scholar 

  • Rodríguez A, Batlle R, Nerín C (2007) The use of natural essential oils as antimicrobial solutions in paper packaging. Part II. Prog Org Coat 60:33–38

    Article  Google Scholar 

  • Shinoda R, Saito T, Okita Y, Isogai A (2012) Relationship between length and degree of polymerization of TEMPO-Oxidized cellulose nanofibrils. Biomacromolecules 13:842–849

    Article  CAS  Google Scholar 

  • Siró I, Plackett D (2010) Microfibrillated cellulose and new nanocomposite materials: a review. Cellulose 17:459–494

    Article  Google Scholar 

  • Spence KL, Venditti RA, Rojas OJ, Habibi Y, Pawlak JJ (2011) A comparative study of energy consumption and physical properties of microfibrillated cellulose produced by different processing methods. Cellulose 18:1097–1111

    Article  CAS  Google Scholar 

  • Suppakul P, Miltz J, Sonneveld K, Bigger SW (2003) Active packaging technologies with an emphasis on antimicrobial packaging and its applications. J Food Sci 68:408–420

    Article  CAS  Google Scholar 

  • Syverud K, Stenius P (2009) Strength and barrier properties of MFC films. Cellulose 16:75–85

    Article  CAS  Google Scholar 

  • Turbak AF, Snyder FW, and Sandberg, KR (1985) Micro-fibrillated cellulose and process for producing it. Pat CH 648071 (A5)

  • Valo H, Arola S, Laaksonen P, Torkkeli M, Peltonen L, Linder MB, Serimaa R, Kuga S, Hirvonen J, Laaksonen T (2013) Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels. Eur J Pharm Sci 50:69–77

    Article  CAS  Google Scholar 

  • Vartiainen J, Motion R, Kulonen H, Rättö M, Skyttä E, Ahvenainen R (2004) Chitosan-coated paper: effects of nisin and different acids on the antimicrobial activity. J Appl Polym Sci 94:986–993

    Article  CAS  Google Scholar 

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Acknowledgments

The authors thank Sandra Tapin-Lingua (FCBA) for supplying the MFC suspension and Cécile Sillard for performing the AFM analyses. This project was made possible by the use of specific equipment of the TekLiCell platform supported by Region Rhône-Alpes through FEDER (European fund for regional development) funding.

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All the authors declare that there are no conflicts of interest.

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Correspondence to Nathalie Lavoine.

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Lavoine, N., Desloges, I., Manship, B. et al. Antibacterial paperboard packaging using microfibrillated cellulose. J Food Sci Technol 52, 5590–5600 (2015). https://doi.org/10.1007/s13197-014-1675-1

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  • DOI: https://doi.org/10.1007/s13197-014-1675-1

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