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Evaluation of RECIST, PERCIST, EORTC, and MDA Criteria for Assessing Treatment Response with Ga68-PSMA PET-CT in Metastatic Prostate Cancer Patient with Biochemical Progression: a Comparative Study

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A Correction to this article was published on 17 August 2020

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Abstract

Purpose

The aim of the study was to compare response evaluation criteria in solid tumours 1.1 (RECIST 1.1), positron emission tomography response criteria in solid tumours (PERCIST), European organisation for research and treatment of cancer (EORTC), and MD Anderson (MDA) criteria for response assessment by Gallium 68-prostate-specific membrane antigen positron emission tomography-computed tomography (Ga68-PSMA PET-CT) in metastatic adenocarcinoma prostate cancer (mPCa) patients with biochemical progression.

Methods

Eighty-eight mPCa patients with pre and post treatment Ga68-PSMA PET-CT were included. A ≥ 25% increase and ≥ 2 ng/ml above the nadir if prostate specific antigen (PSA) drop or ≥ 2 ng/ml above the baseline if PSA does not drop was considered as biochemical progression. RECIST 1.1 and MDA criteria for morphology and PERCIST and EORTC criteria for molecular response were investigated. Percentages of progressive disease (PD), partial response (PR), and stable disease (SD) were calculated. Chi-square test was used for statistical significance.

Results

Proportion of PD, SD, and PR by RECIST 1.1 and MDA criteria were 44 (50.57%), 39 (44.83%), 4 (4.6%), and 33 (39.76%), 48 (57.83%), 2 (2.41%) respectively. Proportion of PD, SD, and PR by PERCIST and EORTC criteria were 71 (80.68%), 11 (12.50%), 6 (6.82%), and 74 (84.09%), 8 (9.09%), 6 (6.82%) respectively. Chi-square test showed statistically significant (P < 0.05) higher proportion of progression detected by both molecular criteria as compare to both morphological criteria.

Conclusion

We concluded that for Ga68-PSMA PET-CT response evaluation, molecular criteria performed better than morphological criteria in mPCa patient with PSA progression.

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Change history

  • 17 August 2020

    The following affiliation has been added to the first author, Manoj Gupta.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India

    Manoj Gupta & Partha Sarathi Choudhury

  2. Department of Uro - Gynae Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India

    Sudhir Rawal

  3. Amity Centre for Radiation Biology, Amity University, Noida, Uttar Pradesh, India

    Harish Chandra Goel

  4. Department of Radiology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India

    S. Avinash Rao

Authors
  1. Manoj Gupta
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  2. Partha Sarathi Choudhury
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  3. Sudhir Rawal
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  4. Harish Chandra Goel
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  5. S. Avinash Rao
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Corresponding author

Correspondence to Manoj Gupta.

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Conflict of Interest

Manoj Gupta, Partha Sarathi Choudhury, Harish Chandra Goel, S Avinash Rao, and Sudhir Rawal declare that they have no conflict of interest.

Ethical Statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

The institutional review board waived the need to obtain informed consent for this retrospective study.

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Gupta, M., Choudhury, P.S., Rawal, S. et al. Evaluation of RECIST, PERCIST, EORTC, and MDA Criteria for Assessing Treatment Response with Ga68-PSMA PET-CT in Metastatic Prostate Cancer Patient with Biochemical Progression: a Comparative Study. Nucl Med Mol Imaging 52, 420–429 (2018). https://doi.org/10.1007/s13139-018-0548-3

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  • DOI: https://doi.org/10.1007/s13139-018-0548-3

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