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The Current Status of SPECT or SPECT/CT in South Korea

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Abstract

The first step to nuclear medicine in Korea started with introduction of the gamma camera in 1969. Although planar images with the gamma camera give important functional information, they have the limitations that result from 2-dimensional images. Single-photon emission computed tomography (SPECT) due to its 3-dimensional image acquisition is superior to earlier planar gamma imaging in image resolution and diagnostic accuracy. As demand for a hybrid functional and anatomical imaging device has increased, integrated SPECT/CT systems have been used. In Korea, SPECT/CT was for the first time installed in 2003. SPECT/CT can eliminate many possible pitfalls on SPECT-alone images, making better attenuation correction and thereby improving image quality. Therefore, SPECT/CT is clinically preferred in many hospitals in various aspects. More recently, additional SPECT/CT images taken from the region with equivocal uptake on planar images have been helpful in making precise interpretation as part of their clinical workup in postoperative thyroid cancer patients. SPECT and SPECT/CT have various advantages, but its clinical application has gradually decreased in recent few years. While some researchers investigated the myocardial blood flow with cardiac PET using F-18 FDG or N-13 ammonia, myocardial perfusion SPECT is, at present, the radionuclide imaging study of choice for the risk stratification and guiding therapy in the coronary artery disease patients in Korea. New diagnostic radiopharmaceuticals for AD have received increasing attention; nevertheless, brain SPECT will remain the most reliable modality evaluating cerebral perfusion.

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References

  1. Medicine TPCottAoKSoN. The 50th Anniversary of the Korean Society of Nuclear Medicine: Korea Medical Book, Seoul; 2011.

  2. Data library on Nuclear Medicine Facilities and Procedures in Korea. The Korean Society of Nuclear Medicine. http://www.ksnm.or.kr/member/pds/stat/ Accessed 15 September 2015.

  3. Berman D, Hachamovitch R, Lewin H, Friedman J, Shaw L, Germano G. Risk stratification in coronary artery disease: implications for stabilization and prevention. Am J Cardiol. 1997;79:10–6.

    Article  CAS  PubMed  Google Scholar 

  4. Berman DS, Hachamovitch R, Kiat H, Cohen I, Cabico JA, Wang FP, et al. Incremental value of prognostic testing in patients with known or suspected ischemic heart disease: a basis for optimal utilization of exercise technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol. 1995;26:639–47.

    Article  CAS  PubMed  Google Scholar 

  5. Shaw LJ, Hendel R, Borges-Neto S, Lauer MS, Alazraki N, Burnette J, et al. Prognostic value of normal exercise and adenosine (99m)Tc-tetrofosmin SPECT imaging: results from the multicenter registry of 4728 patients. J Nucl Med. 2003;44:134–9.

    PubMed  Google Scholar 

  6. Germano G, Erel J, Lewin H, Kavanagh PB, Berman DS. Automatic quantitation of regional myocardial wall motion and thickening from gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol. 1997;30:1360–7.

    Article  CAS  PubMed  Google Scholar 

  7. Germano G, Kavanagh PB, Waechter P, Areeda J, Van Kriekinge S, Sharir T, et al. A new algorithm for the quantitation of myocardial perfusion SPECT. I: technical principles and reproducibility. J Nucl Med. 2000;41:712–9.

    CAS  PubMed  Google Scholar 

  8. Patterson RE, Eisner RL, Horowitz SF. Comparison of cost-effectiveness and utility of exercise ECG, single photon emission computed tomography, positron emission tomography, and coronary angiography for diagnosis of coronary artery disease. Circulation. 1995;91:54–65.

    Article  CAS  PubMed  Google Scholar 

  9. Lee DS, Jang MJ, Cheon GJ, Chung JK, Lee MC. Comparison of the cost-effectiveness of stress myocardial SPECT and stress echocardiography in suspected coronary artery disease considering the prognostic value of false-negative results. J Nucl Cardiol. 2002;9:515–22.

    Article  PubMed  Google Scholar 

  10. Jacobson AF, Senior R, Cerqueira MD, Wong ND, Thomas GS, Lopez VA, et al. Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study. J Am Coll Cardiol. 2010;55:2212–21.

    Article  PubMed  Google Scholar 

  11. Boogers MJ, Borleffs CJ, Henneman MM, van Bommel RJ, van Ramshorst J, Boersma E, et al. Cardiac sympathetic denervation assessed with 123-iodine metaiodobenzylguanidine imaging predicts ventricular arrhythmias in implantable cardioverter-defibrillator patients. J Am Coll Cardiol. 2010;55:2769–77.

    Article  PubMed  Google Scholar 

  12. Marshall A, Cheetham A, George RS, Mason M, Kelion AD. Cardiac iodine-123 metaiodobenzylguanidine imaging predicts ventricular arrhythmia in heart failure patients receiving an implantable cardioverter-defibrillator for primary prevention. Heart. 2012;98:1359–65.

    Article  PubMed  Google Scholar 

  13. Kwon SH, Yoon JK, Yoon JH, Lee SJ, Jo KS, Lee DH, et al. The utility of segmental analysis in cardiac I-123 MIBG SPECT in Parkinson’s disease. Nucl Med Mol Imaging. 2015;49:298–302.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Oh JK, Choi EK, Song IU, Kim JS, Chung YA. Comparison of I-123 MIBG planar imaging and SPECT for the detection of decreased heart uptake in Parkinson disease. J Neural Transm. 2015.

  15. Raynaud C, Rancurel G, Tzourio N, Soucy JP, Baron JC, Pappata S, et al. SPECT analysis of recent cerebral infarction. Stroke. 1989;20:192–204.

    Article  CAS  PubMed  Google Scholar 

  16. Choi H, Yoo MY, Cheon GJ, Kang KW, Chung JK, Lee DS. Parametric cerebrovascular reserve images using Acetazolamide (99m)Tc-HMPAO SPECT: a feasibility study of quantitative assessment. Nucl Med Mol Imaging. 2013;47:188–95.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Hougaard K, Oikawa T, Sveinsdottir E, Skinoj E, Ingvar DH, Lassen NA. Regional cerebral blood flow in focal cortical epilepsy. Arch Neurol. 1976;33:527–35.

    Article  CAS  PubMed  Google Scholar 

  18. Davison CM, O’Brien JT. A comparison of FDG-PET and blood flow SPECT in the diagnosis of neurodegenerative dementias: a systematic review. Int J Geriatr Psychiatry. 2014;29:551–61.

    Article  PubMed  Google Scholar 

  19. Kim JS. Practical approach for the clinical use of dopamine transporter imaging. Nucl Med Mol Imaging DE - 2008-12-01. 2008;42:425–34.

  20. Huellner MW, Strobel K. Clinical applications of SPECT/CT in imaging the extremities. Eur J Nucl Med Mol Imaging. 2014;41 Suppl 1:S50–8.

    Article  PubMed  Google Scholar 

  21. Even-Sapir E, Flusser G, Lerman H, Lievshitz G, Metser U. SPECT/multislice low-dose CT: a clinically relevant constituent in the imaging algorithm of nononcologic patients referred for bone scintigraphy. J Nucl Med. 2007;48:319–24.

    PubMed  Google Scholar 

  22. Linke R, Kuwert T, Uder M, Forst R, Wuest W. Skeletal SPECT/CT of the peripheral extremities. AJR Am J Roentgenol. 2010;194:W329–35.

    Article  PubMed  Google Scholar 

  23. Xue YL, Qiu ZL, Song HJ, Luo QY. Value of (131)I SPECT/CT for the evaluation of differentiated thyroid cancer: a systematic review of the literature. Eur J Nucl Med Mol Imaging. 2013;40:768–78.

    Article  CAS  PubMed  Google Scholar 

  24. Avram AM. Radioiodine scintigraphy with SPECT/CT: an important diagnostic tool for thyroid cancer staging and risk stratification. J Nucl Med Technol. 2014;42:170–80.

    Article  PubMed  Google Scholar 

  25. Rozovsky K, Koplewitz BZ, Krausz Y, Revel-Vilk S, Weintraub M, Chisin R, et al. Added value of SPECT/CT for correlation of MIBG scintigraphy and diagnostic CT in neuroblastoma and pheochromocytoma. AJR Am J Roentgenol. 2008;190:1085–90.

    Article  PubMed  Google Scholar 

  26. Krausz Y, Keidar Z, Kogan I, Even-Sapir E, Bar-Shalom R, Engel A, et al. SPECT/CT hybrid imaging with 111In-pentetreotide in assessment of neuroendocrine tumours. Clin Endocrinol (Oxf). 2003;59:565–73.

    Article  Google Scholar 

  27. Van Binnebeek S, Vanbilloen B, Baete K, Terwinghe C, Koole M, Mottaghy FM, et al. Comparison of diagnostic accuracy of In-pentetreotide SPECT and Ga-DOTATOC PET/CT: a lesion-by-lesion analysis in patients with metastatic neuroendocrine tumours. Eur Radiol. 2016;26:900–9.

  28. Lee I, Paeng JC, Lee SJ, Shin CS, Jang JY, Cheon GJ, et al. Comparison of diagnostic sensitivity and quantitative indices between (68)Ga-DOTATOC PET/CT and (111)in-pentetreotide SPECT/CT in neuroendocrine tumors: a preliminary report. Nucl Med Mol Imaging. 2015;49:284–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Jimenez-Heffernan A, Ellman A, Sado HN, Huic D, Bal C, Parameswaran R, et al. Results of a prospective International Atomic Energy Ahency (IAEA) sentinel node trial on the value of SPECT/CT over planar imaging in various malignancies. J Nucl Med. 2015;56:1338-44.

  30. Na CJ, Kim J, Choi S, Han YH, Jeong HJ, Sohn MH, et al. The clinical value of hybrid sentinel lymphoscintigraphy to predict metastatic sentinel lymph nodes in breast cancer. Nucl Med Mol Imaging. 2015;49:26–32.

    Article  PubMed  Google Scholar 

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Acknowledgments

The study was supported by a grant of Ministry of Science, ICT and Future Planning, Republic of Korea (NRF-2015M3C7A1064832). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Correspondence to Yong-An Chung.

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Ikdong Yoo, Eun Kyoung Choi and Yong-An Chung declare that they have no conflict of interest.

Ethical Statement

The study was approved by an institutional review board or equivalent and has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. The institutional review board waived the need to obtain informed consent.

The manuscript has not been published before or is not under consideration for publication anywhere else and has been approved by all co-authors.

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Ikdong Yoo and Eun Kyoung Choi contributed equally to this work.

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Yoo, I., Choi, E.K. & Chung, YA. The Current Status of SPECT or SPECT/CT in South Korea. Nucl Med Mol Imaging 51, 101–105 (2017). https://doi.org/10.1007/s13139-016-0417-x

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  • DOI: https://doi.org/10.1007/s13139-016-0417-x

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