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99mTc-Labeled RBC Scan in a Patient with Blue Rubber Bleb Nevus Syndrome: A Case Report

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Abstract

Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder characterized by cutaneous and gastrointestinal vascular malformations. We report here the case of a 13-year-old patient with BRBNS who was suffering from chronic anemia. His chief complaint was melena. Contrast-enhanced abdominal computed tomography showed multiple hemangiomas in the small bowel. 99mTc-labeled red blood cell (RBC) scan identified the bleeding sites in the small bowel. The patient underwent exploratory laparotomy with segmental resection and multiple wedge resection of the small bowel. The pathological results confirmed the multiple cavernous hemangiomas. This case confirms the critical role of the 99mTc-labeled RBC scan in localizing the bleeding sites in patients with BRBNS.

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References

  1. Gascoyen M. Case of naevus involving the parotid gland causing death from suffocation: naevi of the viscera. Trans Pathol Soc (Lond). 1860;11:267.

    Google Scholar 

  2. Bean WB. Vascular spiders and related lesions of the skin. Springfield: Charles C Thomas; 1958.

    Google Scholar 

  3. Orange AP. Blue rubber bleb nevus syndrome. Pediatr Dermatol. 1986;3:304–10.

    Article  Google Scholar 

  4. Kassarjian A, Fishman SJ, Fox VL, Burrows PE. Imaging characteristics of blue nevus syndrome. AJR Am J Roentgenol. 2003;181:1041–8.

    Article  PubMed  Google Scholar 

  5. Gallione CJ, Pasyk KA, Boon LM, Lenno F, Johnson DW, Helmbold E, et al. A gene for familial venous malformations maps to chromosome 9p in a second large kindred. J Med Genet. 1995;32:197–9.

    Article  PubMed  CAS  Google Scholar 

  6. Moser CM, Hamsch C. Successful treatment of cutaneous venous malformations in a patient with blue rubber bleb naevus syndrome by Nd:YAG laser. Br J Dermatol. 2012;166:1121–254.

    Article  Google Scholar 

  7. Fishman SJ, Smithers CJ, Folkman J, Lund DP, Burrow PE, Mulliken JB, et al. Blue rubber bleb nevus syndrome, surgical eradication of gastrointestinal bleeding. Ann Surg. 2005;241:523–8.

    Article  PubMed  Google Scholar 

  8. Espoito C, Giurin I, Farina A, Ascione G, Miele E, Stariano A, et al. Blue rubber bleb nevus: an uncommon cause of intestinal intussusceptions. Eur J Pediatr. 2012;171:1139–40.

    Article  Google Scholar 

  9. Dobru D, Seuchea N, Dorin M, Careianu V. Blue rubber bleb nevus syndrome: case report and literature review. Rom J Gastroenterol. 2004;13:237–40.

    PubMed  Google Scholar 

  10. Bonete MD, Cordisco MR, Frontini MD, Asial R. A blue rubber bleb nevus (Bean syndrome): evolution of four cases and clinical response to pharmacologic agents. Pediatr Dermatol. 1999;3:222–7.

    Article  Google Scholar 

Download references

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Correspondence to Ho-Young Lee.

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Lee, S.J., Lee, HY., Jung, K. et al. 99mTc-Labeled RBC Scan in a Patient with Blue Rubber Bleb Nevus Syndrome: A Case Report. Nucl Med Mol Imaging 47, 115–118 (2013). https://doi.org/10.1007/s13139-013-0199-3

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  • DOI: https://doi.org/10.1007/s13139-013-0199-3

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