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Comparison of Everolimus- versus Sirolimus-eluting stents in the provisional Bifurcation stenting guided by intravascular ultrasound: mid-term results of the J-REVERSE registry

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Abstract

This study aimed at comparing the mid-term clinical outcome of everolimus-eluting (EES) with sirolimus-eluting (SES) stents in the provisional bifurcation stenting guided by intravascular ultrasound (IVUS). We compared the clinical outcome up to 9-month follow-up results of the prospective J-REVERSE registry of 300 non-left main bifurcation lesions in 298 patients treated with EES (n = 240) and SES (n = 60). The SB dilation with the kissing balloon technique (KBT) was performed in 54 %. The patient and lesion characteristics of the groups were similar. The incidences of SB dissections, occlusions, stenting, and slow flow were similar. A greater luminal volume gain was achieved in the proximal MV after KBT compared in non-KBT treated lesions in the EES group (7.9 ± 2.4 versus 7.0 ± 2.0 mm3/mm, p = 0.002), though not in the SES group. The SB diameter stenosis in the non-KBT treatment at 9 months was greater than the KBT in both groups. The incidence of target lesion revascularisation (TLR) was 5.0 % in the EES versus 8.3 % in the SES group (p = 0.35), and the incidence of major adverse cardiac events, including TLR, myocardial infarction, stent thrombosis, and death was 5.4 % in the EES versus 11.7 % in the SES group (p = 0.15). IVUS-guided provisional stenting with EES achieved a greater luminal gain after than without KBT, and similar clinical outcomes as with SES up to 9-month follow-up.

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Acknowledgments

J-REVERSE was supported by unrestricted research grants from Abbott Vascular, Cordis Corporation, Orbus Neich, and Kaneka Corporation.

Author information

Authors and Affiliations

  1. Department of Cardiology, Cardiovascular Center, Kyushu Medical Center, 1-8-1, Jigyohama, Fukuoka, Japan

    Yoshinobu Murasato

  2. Clinical Research Institute, Kyushu Medical Center, Fukuoka, Japan

    Yoshinobu Murasato

  3. Department of Cardiovascular Medicine, Toyohashi Heart Center, Toyohashi, Japan

    Yoshihisa Kinoshita

  4. Department of Cardiovascular Medicine, Saiseikai Yokohama-Eastern Hospital, Yokohama, Japan

    Masahiro Yamawaki

  5. Department of Cardiovascular Medicine, Kobe University, Kobe, Japan

    Toshiro Shinke & Hiromasa Otake

  6. Department of Cardiology, Rinku General Medical Center, Izumi-Sano, Japan

    Yoshihiro Takeda

  7. Department of Cardiovascular Medicine, Hyogo Medical University, Nishinomiya, Japan

    Kenichi Fujii

  8. Department of Cardiovascular Medicine, Himeji Cardiovascular Center, Himeji, Japan

    Shin-ichiro Yamada

  9. Department of Cardiovascular Medicine, Cardiovascular Center, Shiroyama Hospital, Habikino, Japan

    Yoshihisa Shimada

  10. Department of Cardiovascular Medicine, Cardiovascular Center Hokkaido Ono Hospital, Sapporo, Japan

    Takehiro Yamashita

  11. Department of Cardiovascular Medicine, Yokohama Rosai Hospital, Yokohama, Japan

    Kazuhiko Yumoto

  12. Department of Cardiovascular Medicine, New Yukuhashi Hospital, Yukuhashi, Japan

    Yoshinobu Murasato

Authors
  1. Yoshinobu Murasato
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  2. Yoshihisa Kinoshita
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  3. Masahiro Yamawaki
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  5. Hiromasa Otake
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  7. Kenichi Fujii
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  8. Shin-ichiro Yamada
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  9. Yoshihisa Shimada
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  10. Takehiro Yamashita
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  11. Kazuhiko Yumoto
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Corresponding author

Correspondence to Yoshinobu Murasato.

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On behalf of J-REVERSE investigators.

Appendix

Appendix

List of participating centers and investigators.

Masaya Arikawa, Tetsuya Kira, Oita Medical Center; Yoritaka Otsuka, Fukuoka Wajiro Hospital; Masaki Tanabe, The Second Okamoto Hospital; Yoshinobu Murasato, Kyushu Medical Center and New Yukuhashi Hospital; Masataka Horiuchi, Yasunori Suematsu, Tomohiko Yamamoto, Taichi Okonogi, New Yukuhashi Hospital; Yoshihisa Kinoshita, Takahiko Suzuki, Toyohashi Heart Center; Masahiro Yamawaki, Toshiya Muramatsu, Reiko Tsukahara, Norihiro Kobayashi, Saiseikai Yokohama-Eastern Hospital; Toshiro Shinke, Hirotoshi Hariki, Kobe University; Yoshihiro Takeda, Rinku General Medical Center; Shin-ichiro Yamada, Himeji Cardiovascular Center; Kenichi Fujii, Hyogo Medical University; Yoshihisa Shimada, Naoto Kino, Daisuke Tonomura, Shiroyama Hospital; Takehiro Yamashita, Masato Nagashima, Cardiovascular Center Hokkaido Ono Hospital; Kazuhiko Yumoto, Yokohama Rosai Hospital.

Core laboratory: Yasuyoshi Suzuki, Mitsuyasu Terashima, Cardiovascular Imaging Center; Hiromasa Otake, Hachidai Takahashi, Hiroto Kinutani, Daisuke Terashita.

Statistical Adviser: Yoshihisa Fujino, University of Occupational Environmental Health.

Safety Committee: Yoshinori Takajyo, Takajyo Clinic; Masato Tsutsui, Ryukyu University.

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Murasato, Y., Kinoshita, Y., Yamawaki, M. et al. Comparison of Everolimus- versus Sirolimus-eluting stents in the provisional Bifurcation stenting guided by intravascular ultrasound: mid-term results of the J-REVERSE registry. Cardiovasc Interv and Ther 31, 1–12 (2016). https://doi.org/10.1007/s12928-015-0336-2

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  • DOI: https://doi.org/10.1007/s12928-015-0336-2

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