Abstract
The poor outcomes surrounding pancreatic cancer (5 % 5-year survival) are rooted in the advanced nature of the cancer at diagnosis, aggressiveness of the tumor, technical challenges for surgical treatment, and the limitations of systemic therapies. Research on pancreatic cancer and diet has focused on the effects of bioactive food compounds upon major pathways in cancerous cell development, particularly with the active components of flavonoids, proteins, and vitamins. Such bioactive components, particularly found in fruits and vegetables, have been associated with increased sensitivity to chemotherapeutic drugs for treating pancreatic cancer and inhibiting angiogenesis and cancerous cell growth. Diet-based approaches to prevention and treatment of pancreatic cancer may thus offer clinical efficacious and cost-effective opportunities to optimize existing modes of treatment (surgery, systemic therapies, radiotherapies, and palliative care), offset rising medical costs for patients, and improve quality of life for patients undergoing treatment. Integration of these findings at the clinical level may require a national, scalable model such as that of Tulane University School of Medicine’s Goldring Center for Culinary Medicine (GCCM) to meaningfully improve the care of health care providers for pancreatic cancer patients.
Similar content being viewed by others
References
Jemal A, Siegel R, Xu J, Ward E (2010) Cancer statistics. CA Cancer J Clin 60:277–300
Birkhead A, Foote S, Monlezun DJ, Loyd J, Joo E, Leong B, Sarris L, Harlan T (2013) Medical student-led community cooking classes: a novel preventative medicine model easy to swallow. Am J Prev Med 46:e41–e42
Hong C, Abrams M, Ferris T (2014) Toward increased adoption of complex care management. N Engl J Med 371:491–493
Gil-Izquierdo A, Gil M, Ferreres F, Tomas-Barberan F (2001) In vitro availability of flavonoids and other phenolics in orange juice. J Agric Food Chem 49:1035–1041
Melstrom L, Salabat M, Ding X, Milam B et al (2008) Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide 3-kinase/Akt pathway in human pancreatic cells. Pancreas 37:426–431
Johnson J, Gonzalez de Mejia E (2011) Dietary factors and pancreatic cancer: the role of food bioactive compounds. Mol Nutr Food Res 55:58–73
Salabat M, Melstrom L, Strouch M, Ding X et al (2008) Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavonoid apigenin in pancreatic cancer cell lines. Mol Carcinog 47:835–844
Ujiki M, Ding X, Salabat M, Bentrem D et al (2006) Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest. Mol Cancer 5:76
Pu P, Wang X, Salim M, Zhu L, Wang L, Chen K, Xiao J, Deng W, Shi H, Jiang H, Li H (2012) Baicalein, a natural product, selectively activating AMPKa2 and ameliorates metabolic disorder in diet-induced mice. Mol Cell Endocrinol 362:1128–1138
Takashi H, Chen M, Pham H, Angst E, King J, Park J, Brovman E, Ishiguor H, Harris D, Reber H, Hines O, Gukovskaya A, Go V, Eibl G (2011) Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Biochim Biophys Acta 1813:1465–1474
Gibellini L, Pinti M, Nasi M, Montagna J, De Biasi S, Roat E, Bertoncelli L, Cooper EL, Cossarizza A (2010) Quercetin and cancer chemoprevention. Evid Based Complementary Altern Med 2011:1–15
Banerjee S, Zhang Y, Ali S, Bhuiyan M et al (2005) Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res 65:9064–9072
Mohammad R, Banerjee S, Li Y, Aboukameel A et al (2006) Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenografts. Cancer 106:1260–1268
Johnson J, Gonzalez de Mejia E (2011) Dietary factors and pancreatic cancer: the role of food bioactive compounds. Mol Nutr Food Res 55:58–73
Banerjee S, Zhang Y, Ali S, Bhuiyan M et al (2005) Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res 65:9064–9072
Fontana L, Adelaiye R, Rastelli A, Miles K, Ciamporcero E, Longo V, Nguyen H, Vessella R, Pili R (2013) Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer. Oncotarget 4:2451–2461
Z’graggen K, Warshaw A, Werner J, Graeme-Cook F, Jimenez R, Fernandez-del Castillo C (2001) Promoting effect of a high-fat/high-protein diet in DMBA-induced ductal pancreatic cancer in rats. Ann Surg 233(5):688–695
Bao Y, Ng K, Wolpin B, Michaud D et al (2010) Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies. Br J Cancer 102:1422–1427
Skinner H, Michaud D, Giovannucci E, Willett W et al (2006) Vitamin D intake and the risk for pancreatic cancer in two cohort studies. Cancer Epidemiol Biomark Prev 15:1688–1695
Huang P, Chuang H, Chou C, Wang H, Lee S, Yang H, Chiu H, Kapuriya N, Wang D, Kulp S, Chen C (2013) Vitamin E facilitations the inactivation of kinase Akt by the phosphatase PHLPP1. Sci Signal 6(267):1–13
Nitsche C, Edderkaoui M, Moore R, Eibl G, Kasahara N, Treger J, Grippo P, Mayerle J, Lerch M, Gukovskaya A (2012) Phosphatase PHLPP1 regulations Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation. Gastroenterology 142:377–387
Shane B, Alexopolous Y, Hebberd K, Vales S (2006) Folic acid, vitamin B12, and vitamin B6—biochemical, physiological, and molecular aspects of human nutrition. Saunders Elsevier, St. Louis, pp 694–712
Mason J, Choi S (2000) Folate and carcinogenesis: developing a unifying hypothesis. Adv Enzyme Regul 40:127–141
Becker A, Hernandez Y, Frucht H, Lucas A (2014) Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection. World J Gastroenterol 20(32):11182–11198
Genkinger JM, Spiegelman D, Anderson KE, Bergkvist L, Bernstein L, van den Brandt PA, English DR, Freudenheim JL, Fuchs CS, Giles GG (2009) Alcohol intake and pancreatic cancer risk: a pooled analysis of fourteen cohort studies. Cancer Epidemiol Biomarkers Prev 18:765–776
Tramacere I, Scotti L, Jenab M, Bagnardi V, Bellocco R, Rota M, Corrao G, Bravi F, Boffetta P, La Vecchia C (2010) Alcohol drinking and pancreatic cancer risk: a meta-analysis of the dose-risk relation. Int J Cancer 126:1474–1486
Duell EJ (2012) Epidemiology and potential mechanisms of tobacco smoking and heavy alcohol consumption in pancreatic cancer. Mol Carcinog 51:40–52
Noreel SE, Ahlbom A, Erwarld R, Jacobson G, Lindberg-Navier I, Olin R, Tornberg B, Wiechel KL (1986) Diet and pancreatic cancer: a case–control study. Am J Epidemiol 124(6):894–902
Michaud DS, Giovannucci E, Willett WC, Colditz GA, Fuchs CS (2001) Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts. Cancer Epidemiol Biomark Prev 10(5):429–437
Bardou M, Le Ray I (2013) Treatment of pancreatic cancer: a narrative review of cost-effectiveness studies. Best Pract Res Clin Gastroenterol 27:881–892
Acknowledgments
The authors would like to express their profound gratitude for the patients and medical professionals who make possible the ongoing multi-center national trials for GCCM.
Financial disclosures: The authors have no financial disclosures.
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Monlezun, D.J., Tsai, P., Sarris, L. et al. Recipe for cancer education: a novel integrated cooking and nutrition education curriculum for medical students and physicians in dietary preventive and supplemental treatment for pancreatic cancer. J Med Pers 12, 125–128 (2014). https://doi.org/10.1007/s12682-014-0190-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12682-014-0190-5