Abstract
Background
There is a paucity of data on the demographic and clinicopathological profiles of patients with chronic pancreatitis from the eastern part of India. This study documents the demographic and clinicopathological profiles of patients with chronic pancreatitis presenting to a general surgery unit of a tertiary referral hospital of Kolkata.
Methods
The records of 145 patients presenting with chronic pancreatitis over a 5-year period were scrutinized and their demographics, clinical profile, and complications and morphological changes of the pancreas are described.
Results
Of the 145 patients, more than 50 % were under the age of 30 years. Males were affected more frequently than females (M/F = 3.8:1). While idiopathic pancreatitis was the most common form of chronic pancreatitis (41.4 %), alcohol was found to be the most common etiology (37.9 %). Pain was the most common presenting symptom (n = 143; 98.6 %). Sixty-five subjects (45 %) had diabetes of which 32 subjects were insulin-dependent. On contrast-enhanced computed tomography, ductal dilatation was seen in 80 (55.17 %) subjects, while ductal calculi and ductal dilatation in 54 cases (37.2 %). Parenchymal calcification was seen in 45 patients of whom 40 patients (89 %) were under the age of 30 years. Pseudocyst was the most common complication (n = 16) followed by biliary obstruction (n = 8) and portal hypertension (n = 4). Patients with alcoholic pancreatitis had significantly higher frequency of severe abdominal pain, diabetes, and local complications as compared to the other forms of pancreatitis in our study.
Conclusion
Idiopathic pancreatitis was the most common form of chronic pancreatitis in this study, followed by alcoholic pancreatitis and then tropical pancreatitis.
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References
Bellin MA, Freeman ML, Gelrud A, et al. Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. Pancreatology. 2014;14:27–35.
Etemad B, Whitcomb DC. Chronic pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology. 2001;120:682–707.
Otsuki M. Chronic pancreatitis in Japan: epidemiology, prognosis, diagnostic criteria, and future problems. J Gastroenterol. 2003;38:315–26.
Lin Y, Tamakoshi A, Matsuno S, et al. Nationwide epidemiological survey of chronic pancreatitis in Japan. J Gastroenterol. 2000;35:136–41.
Bhasin DK, Singh G, Rana SS, et al. Clinical profile of idiopathic chronic pancreatitis in North India. Clin Gastroenterol Hepatol. 2009;7:594–9.
Bhasin DK, Rana SS, Chandail VS, et al. Clinical profile of calcific and noncalcific chronic pancreatitis in north India. J Clin Gastroenterol. 2011;45:546–50.
Rajesh G, Veena AB, Menon S, Balakrishnan V. Clinical profile of early-onset and late-onset idiopathic chronic pancreatitis in South India. Indian J Gastroenterol. 2014;33:231–6.
Balakrishnan V, Unnikrishnan AG, Thomas V, et al. Chronic pancreatitis. A prospective nationwide study of 1086 subjects from India. JOP. 2008;9:593–600.
Veena AB, Rajesh G, Varghese J, Sundaram KR, Balakrishnan V. Alcoholic chronic pancreatitis and alcoholic liver cirrhosis: differences in alcohol use habits and patterns in Indian subjects. Pancreas. 2012;41:703–6.
Tinto A, Lloyd DA, Kang JY, et al. Acute and chronic pancreatitis—disease on the rise: a study of hospital admissions in England 1989/90-1999/2000. Aliment Pharmacol Ther. 2002;16:2097–105.
Garg PK, Tandon RK. Survey of chronic pancreatitis in Asia-Pacific region. J Gastroenterol Hepatol. 2004;19:998–1004.
Balaji LN, Tandon RK, Tandon BN, Banks PA. Prevalence and clinical features of chronic pancreatitis in southern India. Int J Pancreatol. 1994;15:29–34.
Tandon RK, Sato N, Garg PK; Consensus Study Group. Chronic pancreatitis: Asia-Pacific consensus report. J Gastroenterol Hepatol. 2002;17:508–18.
Wang LW, Li ZS, Li SD, Jin ZD, Zou DW, Chen F. Prevalence and clinical features of chronic pancreatitis in China: a retrospective multicenter analysis over 10 years. Pancreas. 2009;38:248–54.
Balakrishnan V, Nair P, Radhakrishnan L, Narayanan VA. Tropical pancreatitis—a distinct entity, or merely a type of chronic pancreatitis? Indian J Gastroenterol. 2006;25:74–81.
Li JN, Lai YM, Qian JM, Guo T, Lu H, Tang XY. Trends in aetiologies of chronic pancreatitis within 20 years: analysis of 636 cases. Chin Med J (Engl). 2011;124:3556–9.
Yadav D, Hawes RH, Brand RE, et al. Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. Arch Intern Med. 2009;169:1035–45.
Lin Y, Tamakoshi A, Hayakawa T, Ogawa M, Ohno Y. Cigarette smoking as a risk factor for chronic pancreatitis: a case-control study in Japan. Research Committee on Intractable Pancreatic Diseases. Pancreas. 2000;21:109–14.
Lowenfels AB, Maisonneuve P, Whitcomb DC, Lerch MM, DiMagno EP. Cigarette smoking as a risk factor for pancreatic cancer in patients with hereditary pancreatitis. JAMA. 2001;286:169–70.
Qian JM. Etiologic analysis of chronic pancreatitis in China. Chin J Pacreatol. 2004;4:65–7.
Gu ZY, Zhang KH. Chronic pancreatitis in China: etiology and management. World J Surg. 1990;14:28–31.
Pareja E, Mir J, Artigues E, Martínez V, Fabra R, Trullenque R. Acute biliary pancreatitis: does the pancreas change morphologically in the long run? Pancreatology. 2005;5:59–64.
Misra SP, Gulati P, Choudhary V, Anand BS. Pancreatic duct abnormalities in gall stone disease: an endoscopic retrograde cholangiopancreatographic study. Gut. 1990;31:1073–5.
Garg PK, Tandon RK. Two different patterns of chronic pancreatitis: one disease or two? J Gastroenterol Hepatol 2000; 15 Suppl:A205 (Abstract).
Cooperman AM. Surgery and chronic pancreatitis. Surg Clin North Am. 2001;81:431–55.
Ammann RW, Buehler H, Muench R, Freiburghaus AW, Siegenthaler W. Differences in the natural history of idiopathic (non-alcoholic) and alcoholic chronic pancreatitis. A comparative long-term study of 287 patients. Pancreas. 1987;2:368–77.
Grace PA, Williamson RC. Modern management of pancreatic pseudocysts. Br J Surg. 1993;80:573–81.
Rerknimitr R. Asian chronic pancreatitis: the common and the unique. J Gastroenterol Hepatol. 2011;26 Suppl 2:6–11.
Midha S, Khajuria R, Shastri S, Kabra M, Garg PK. Idiopathic chronic pancreatitis in India: phenotypic characterisation and strong genetic susceptibility due to SPINK1 and CFTR gene mutations. Gut. 2010;59:800–7.
Balakrishnan V, Kumar H, Sudhindran S, et al. Chronic pancreatitis and pancreatic diabetes in India. Kochi: Indian Pancreatitis Study Group; 2006, www.ipans.org.
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PKB, AM, and CA declare that they have no competing interests.
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The study was performed in a manner to confirm to the Helsinki Declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown in Springer.com.
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Bhattacharjee, P.K., Mukerjee, A. & Adhikary, C. Demographic and clinicopathological profile of patients with chronic pancreatitis in a tertiary referral teaching hospital of West Bengal: Personal experience. Indian J Gastroenterol 34, 365–371 (2015). https://doi.org/10.1007/s12664-015-0594-z
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DOI: https://doi.org/10.1007/s12664-015-0594-z