Abstract
Purpose
The purpose of this systematic review was to evaluate, in animal model-based studies, whether there are mandibular growth alterations, after open reduction and internal rigid fixation with titanium plates and screws.
Methods
A literature search was conducted using the MEDLINE, EMBASE, and LILACS databases, up to and including August 2015. Surgical reduction and internal rigid fixation (IRF) of induced fractures were compared to non-invasive procedures, in order to investigate if there were alterations in the mandibular growth patterns.
Results
Of a total of 624 potentially relevant papers identified through the searching process, five were eligible for inclusion. Three studies using 3-month old New Zealand white rabbits induced fractures of mandibular body or symphysis and internal fixation with titanium microplates and screws, whereas two were based on 6-month old goats with condylar fracture. None of the studies showed statistically significant difference between experimental and control groups.
Conclusion
As literature regarding this subject is scarce, and the included studies show low level of evidence, it is not possible to conclude that open reduction and internal rigid fixation with titanium plates and screws cause significant growing alteration of the mandible.
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References
Demianczuk AN, Verchere C, Phillips JH (1999) The effect on facial growth of pediatric mandibular fractures. J Craniofac Surg 10:323
Imahara SD, Hopper RA, Wang J et al (2008) Patterns and outcomes of pediatric facial fractures in the United States: a survey of the national trauma data bank. J Am Coll Surg 207:710
Eppley BL, Prevel CD (1997) Nonmetallic fixation in traumatic midfacial fractures. J Craniofac Surg 8:103
Waldron CW, Kazanjian VH, Parker DB (1943) Skeletal fixation in the treatment of fractures of the mandible: a review. J Oral Surg 1:59
Persing JA, Babler WJ, Jane JA et al (1986) Experimental unilateral coronal synostosis in rabbits. Plast Reconstr Surg 77:369
Marschall MA, Chidyllo SA, Figueroa AA et al (1991) Long-term effects of rigid fixation on the growing craniomaxillofacial skeleton. J Craniofac Surg 2:63
Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Methods of systematic reviews and meta-analysis preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 62:1006
Higgins JP, Green S (eds) (2011) Cochrane handbook for systematic reviews of interventions. Version 5.0.1. Cochrane Collab. http://www.cochrane.org/training/cochranehandbook. Updated Sep 2011. Accessed 13 Jul 2015
Chambrone L, Chambrone LA, Lima LA (2010) Effects of occlusal overload on peri-implant tissue health: a systematic review of animal model studies. J Periodontol 81:1367
Chambrone L, Mandia J Jr, Shibli JA et al (2013) Dental implants installed in irradiated jaws: a systematic review. J Dent Res 92:119S
Uckan S, Bayram B, Kecik D et al (2009) Effects of titanium plate fixation on mandibular growth in a rabbit model. J Oral Maxillofac Surg 67:318
Bayram B, Yilmaz AC, Ersoz E et al (2012) Does the titanium plate fixation of symphyseal fracture affect mandibular growth? J Craniofac Surg 23:e601
Fernandez H, Osorio J, Russi MT et al (2012) Effects of internal rigid fixation on mandibular development in growing rabbits with mandibular fractures. J Oral Maxillofac Surg 70:2368
Feng Z, Li L, He D et al (2012) Role of retention of the condylar cartilage in open treatment of intracapsular condylar fractures in growing goats: three-dimensional computed tomographic analysis. Brit J Oral Maxillofac Surg 50:523
Li L, Feng Z, Ma R et al (2013) The comparative study of mandibular ramus growth with different treatment methods for intracapsular condylar fracture. J Craniofac Surg 24:657
Bos RR (2005) Treatment of pediatric facial fractures: the case for metallic fixation. J Oral Maxillofac Surg 63:382
Myall RW (2009) Management of mandibular fractures in children. Oral Maxillofac Surg Clin N Am 21:197
Baby J, Reena RJ, Stalin A, Elango I (2010) Management of mandibular body fractures in pediatric patients: a case report with review of literature. Contemp Clin Dent 1:291
Siy RW, Brown RH, Koshy JC et al (2011) General management considerations in pediatric facial fractures. J Craniofac Surg 22:1190
DeConde AS, Sidell DR, Aghaloo T et al (2012) The segmental mandibular critical size defect in the rat. Otolaryng Head Neck 147:43
Deconde AS, Lee MK, Sidell D et al (2014) Defining the critical-sized defect in a rat segmental mandibulectomy model. JAMA Otolaryngol Head Neck Surg 140:58
Chiodo AA, Gur E, Pang CY et al (2000) The vascularized pig fibula bone flap model: effect of segmental osteotomies and internal fixation on blood flow. Plast Reconstr Surg 105:1004
Ellis E III (1988) Mobility of the mandible following advancement and maxillomandibular or rigid internal fixation: an experimental investigation in Macaca mulatta. J Oral Maxillofac Surg 46:118
Neff A, Chossegros C, Blanc JL (2014) Position paper from the IBRA symposium on surgery of the head: the 2nd international symposium for condylar fracture osteosynthesis, Marseille, France 2012. J Cranio Maxillofac Surg 42:1234
Kushner GM, Tiwana PS (2009) Fractures of the growing mandible. Atlas Oral Maxillofac Surg Clin N Am 17:81
Additional References
Amaratunga NA (1988) Mandibular fractures in children: a study of clinical aspects, treatment needs, and complications. J Oral Maxillofac Surg 46:637
Crean ST, Sivarajasingam V, Fardy MJ (2000) Conservative approach in the management of mandibular fractures in the early dentition phase. A case report and review of the literature. Int J Paediatr Dent 10:229
Gawelin PJ, Thor AL (2005) Conservative treatment of paediatric mandibular fracture by the use of orthodontic appliance and rubber elastics: report of a case. Dent Traumatol 21:57
Holland AJ, Broome C, Steinberg A et al (2001) Facial fractures in children. Pediatr Emerg Care 17:157
Kaban LB (1993) Diagnosis and treatment of fractures of the facial bones in children 1943–1993. J Oral Maxillofac Surg 51:722
Laster Z, Muska EA, Nagler R (2008) Pediatric mandibular fractures: introduction of a novel therapeutic modality. J Trauma 64:225
Posnick J, Wells M, Pron GE (1993) Pediatric facial fractures: evolving patterns of treatment. J Oral Maxillofac Surg 51:836
Rowe NL (1969) Fractures of the jaws in children. J Oral Surg 27:497
Senel FC, Tekin US, Imamoglu M (2006) Treatment of a mandibular fracture with biodegradable plate in an infant: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:448
Simon BR, Woo SL, McCarty M et al (1978) Parametric study of bone remodeling beneath internal fixation plates of varying stiffness. J Bioeng 2:543
Torgersen S, Gilhuus-Moe OT, Gjerdet NR (1993) Immune response to nickel and some clinical observations after stainless Steel miniplate osteosynthesis. Int J Oral Maxillofac Surg 22:246
Turvey TA, Ruiz RL, Blakey GH III, Biron RT, Levin LM (2004) Management of facial fracture in growing patient. In: Fonseca RJ, Walker VR, Betts NJ (eds) Oral and maxillofacial trauma, 3rd edn. Elsevier Saunders, St Louis, pp 967–1000
Zimmermann CE, Troulis MJ, Kaban LB (2006) Pediatric facial fractures: recent advances in prevention, diagnosis and management. Int J Oral Maxillofac Surg 35:2
Acknowledgments
We want to thank Sabrina Castillo for her support and collaboration during the preparation of this article.
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This study wasn´t funded by any person, institution or company.
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Ethical Approval Statement
This article contains just one study with animals performed by one of the authors. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed on it. This article does not contain any other studies with animals performed by any of the authors.
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Authors Humberto Fernández Olarte, Andrés Gómez-Delgado, Dayán López-Dávila, Rodolfo Rangel-Perdomo, Gloria Inés Lafaurie, Leandro Chambrone declares that they have no conflict of interest.
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Fernández-Olarte, H., Gómez-Delgado, A., López-Dávila, D. et al. Is the Mandibular Growth Affected by Internal Rigid Fixation?: A Systematic Review. J. Maxillofac. Oral Surg. 16, 277–283 (2017). https://doi.org/10.1007/s12663-016-0968-5
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DOI: https://doi.org/10.1007/s12663-016-0968-5