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Botulinum Toxin in the Treatment of Muscle Specific Oro-Facial Pain: A Literature Review

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Abstract

Facial pain associated with temporomandibular joint (TMJ) and surrounding structures has been a challenge to clinicians as far as diagnosis and management is concerned. Complexity of anatomical structures within a small area, function of teeth and surrounding periodontal ligament, action of muscles, pathologies, lack of diagnostic investigations, all these complicate specific diagnosis of TMJ disorders. Various classifications have been designed and studied to help diagnose and treat TMJ related disorders, of which the simplest one is pain from TMJ proper and surrounding muscles. Many treatment modalities to treat pain arising from muscles around TMJ like splints, mouth restriction exercises, injection of sclerosing agents etc. have been used with various degrees of success. Botulinum toxin has been shown to be effective in the treatment of oro-facial pain due to muscular disorders and the same is discussed in detail in this review literature.

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References

  1. DuBrul EL (1980) Sicher’s oral anatomy. 7th ed. C.V. Mosby, St. Louis (MO), p 146–61, 174–209

  2. Carlsson GE (1999) Epidemiology and treatment need for temporomandibular disorders. J Orofac Pain 13:232–237

    CAS  PubMed  Google Scholar 

  3. Bentsianov B et al (2004) Botulinum toxin treatment for TMD. Operative Tech Otolaryngol Head Neck Surg 15(2):110–113

    Article  Google Scholar 

  4. Schwartz M, Freund B (2002) Treatment of temporomandibular disorders with botulinum toxin. Clin J Pain 18(suppl 6):S198–S203

    Article  PubMed  Google Scholar 

  5. Manfredini D, Guarda-Nardini L, Winocur E, Piccotti F, Ahlberg J, Lobbezoo F (2011) Research diagnostic criteria for temporomandibular disorders: a systematic review of axis I: epidemiologic findings. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112(4):453–462

    Article  PubMed  Google Scholar 

  6. Herb et al (2006) Temporomandibular joint pain and dysfunction. Curr Pain Headache Rep 10:408–414

    Article  PubMed  Google Scholar 

  7. Freund B, Schwartz M, Symington JM (2000) Botulinum toxin: new treatment for temporomandibular disorders. Br J Oral Maxillofac Surg 38:466–471

    Article  CAS  PubMed  Google Scholar 

  8. Simpson LL (1981) The origin, structure, and pharmacological activity of botulinum toxin. Pharmacol Rev 33:155–188

    CAS  PubMed  Google Scholar 

  9. Scott AB (1980) Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery. Ophthalmology 87:1044

    Article  CAS  PubMed  Google Scholar 

  10. Jankovic J (1986) Blepharospasm with basal ganglia lesions. Arch Neurol 43:866

    Article  CAS  PubMed  Google Scholar 

  11. Jankovic J, Fahn S (1988) Dystonic syndromes. In: Jankovic J, Tolosa E (eds) Parkinson’s Disease and Movement Disorders. Urban & Schwarzenberg, Baltimore, MD, pp 283–314

    Google Scholar 

  12. Jankovic J, Orman J (1987) Botulinum A toxin for cranial-cervical dystonia: a double-blind, placebo-controlled study. Neurology 37:616

    Article  CAS  PubMed  Google Scholar 

  13. Blitzer A, Brin MF, Green PE et al (1989) Botulinum toxin injection for the treatment of oromandibular dystonia. Trans Am Laryngol Assoc San Francisco 110(April):1–2

    Google Scholar 

  14. Simpson LL (1981) The origin, structure, and pharmacological activity of botulinum toxin. Pharmacol Rev 33:155–188

    CAS  PubMed  Google Scholar 

  15. Brin MF (1997) Botulinum toxin: chemistry, pharmacology, toxicity, and immunology. Muscle Nerve Suppl 6:S146–S168

    Article  CAS  PubMed  Google Scholar 

  16. Wheeler AH (2004) Myofascial pain disorders: theory to therapy. Drugs 64(1):45–62

    Article  CAS  PubMed  Google Scholar 

  17. Göbel H (2003) Jost WH: Botulinum toxin in specific pain therapy. Schmerz 17:149–165

    Article  PubMed  Google Scholar 

  18. Schwartz M, Freund B (2002) Treatment of temporomandibular disorders with botulinum toxin. Clin J Pain 18(suppl 6):S198–S203

    Article  PubMed  Google Scholar 

  19. Girdler NM (1994) Use of botulinum toxin to alleviate facial pain (letter). Br J Hosp Med 52:363

    CAS  PubMed  Google Scholar 

  20. von Lindern JJ, Niederhagen B, Appel T et al (2001) Type A botulinum toxin for the treatment of hypertrophy of the masseter and temporal muscles: an alternative treatment. Plast Reconstr Surg 107:327–332

    Article  Google Scholar 

  21. von Lindern JJ, Niederhagen B, Berge S et al (2003) Type A botulinum toxin in the treatment of chronic facial pain associated with masticatory hyperactivity. J Oral Maxillofac Surg 61:774–778

    Article  Google Scholar 

  22. Isaac AM, Moss CE, Whear NM (2000) Unilateral temporalis muscle hypertrophy managed with botulinum toxin type-A. Br J Oral Maxillofac Surg 38:571–2. Comments in: Br J Oral Maxillofac Surg 2001;39:483

  23. To EW, Ahuja AT, Ho WS et al (2001) A prospective study of the effect of botulinum toxin A on masseteric muscle hypertrophy with ultrasonographic and electromyographic measurement. Br J Plast Surg 54:197–200

    Article  CAS  PubMed  Google Scholar 

  24. Moore AP, Wood GD (1997) Medical treatment of recurrent temporomandibular joint dislocation using botulinum toxin A. Br Dent J 183:415–417

    Article  CAS  PubMed  Google Scholar 

  25. Daelen B, Thorwirth V, Koch A (1997) Treatment of recurrent dislocation of the temporomandibular joint with type A botulinum toxin. Int J Oral Maxillofac Surg 26:458–460

    Article  CAS  PubMed  Google Scholar 

  26. Bakke M, Moller E, Werdelin LM, Dalager T, Kitai N, Kreiborg S (2005) Treatment of severe temporomandibular joint clicking with botulinum toxin in the lateral pterygoid muscle in two cases of anterior disc displacement. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:693–700

    Article  PubMed  Google Scholar 

  27. Karacalar A, Yilmaz N, Bilgici A, Baş B, Akan H (2005) Botulinum toxin for the treatment of temporomandibular joint disk disfigurement: clinical experience. J Craniofac Surg 16:476–481

    Article  PubMed  Google Scholar 

  28. Arinci Atilla et al (2005) Effect of injection of botulinum toxin on lateral pterygoid muscle used together with the arthroscopy in patients with anterior disk displacement of the temporomandibular joint. J Cranf Surg 19:122

    Google Scholar 

  29. Blitzer A, Brin MF, Greene PE, Fahn S (1989) Botulinum toxin injection for the treatment of oromandibular dystonia. Ann Otol Rhinol Laryngol 98:93–97

    Article  CAS  PubMed  Google Scholar 

  30. Van Zandijcke M, Marchau MM (1990) Treatment of bruxism with botulinum toxin injections. J Neurol Neurosurg Psychiatry 53:530

    Article  PubMed Central  PubMed  Google Scholar 

  31. Tan EK, Jankovic J (2000) Treating severe bruxism with botulinum toxin. J Am Dent Assoc 131:211–216

    Article  CAS  PubMed  Google Scholar 

  32. Monroy PG, da Fonseca MA (2006) The use of botulinum toxin-A in the treatment of severe bruxism in a patient with autism: a case report. Spec Care Dentist 26:37–39

    Article  PubMed  Google Scholar 

  33. Guarda-Nardini L, Manfredini D, Salamone M et al (2008) Efficacy of botulinum toxin in treating myofascial pain in bruxers: a controlled placebo pilot study. Cranio 26:126–135

    PubMed  Google Scholar 

  34. Eleopra R, Tugnoli V, Caniatti L, De Grandis D (1996) Botulinum toxin treatment in the facial muscles of humans: evidence of an action in untreated near muscles by peripheral local diffusion. Neurology 46:1158–1160

    Article  CAS  PubMed  Google Scholar 

  35. Song PC, Schwartz J, Blitzer A (2007) The emerging role of botulinum toxin in the treatment of temporomandibular disorders. Oral Dis 13:253–260

  36. Lee EH, Kim JY, Kweon HY, Jo YY, Min SK, Park YW et al (2010) A combination graft of low-molecular-weight silk fibroin with Choukroun’s platelet-rich fibrin for rabbit calvarial defect. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:e33–e38

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Rungta College of Dental Sciences and Research, Bhilai, India

    C. Sunil Dutt, Pooja Ramnani, Deepak Thakur & Manish Pandit

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  1. C. Sunil Dutt
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  2. Pooja Ramnani
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  3. Deepak Thakur
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  4. Manish Pandit
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Correspondence to C. Sunil Dutt.

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Sunil Dutt, C., Ramnani, P., Thakur, D. et al. Botulinum Toxin in the Treatment of Muscle Specific Oro-Facial Pain: A Literature Review. J. Maxillofac. Oral Surg. 14, 171–175 (2015). https://doi.org/10.1007/s12663-014-0641-9

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  • DOI: https://doi.org/10.1007/s12663-014-0641-9

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