Skip to main content

Advertisement

SpringerLink
Log in

Can the Immunological Response to Botulinum Toxin Trigger Headaches?

  • Commentary
  • Published:
Neurotoxicity Research Aims and scope Submit manuscript

Abstract

OnabotulinumtoxinA has recently proved beneficial for the treatment of chronic migraine; even though, headaches are not infrequently reported by patients receiving botulinum toxins for different conditions. Here the author discusses the potential mechanisms on how the immunological response following the application of botulinum toxins may trigger headaches and/or migraine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Baizabal-Carvallo JF, Jankovic J, Feld J (2013) Flu-like symptoms and associated immunological response following therapy with botulinum toxins. Neurotox Res 24:298–306

    Article  CAS  PubMed  Google Scholar 

  • Bø SH, Davidsen EM, Gulbrandsen P et al (2009) Cerebrospinal fluid cytokine levels in migraine, tension-type headache and cervicogenic headache. Cephalalgia 29:365–372

    Article  PubMed  Google Scholar 

  • Diener HC, Dodick DW, Turkel CC et al (2014) Pooled analysis of the safety and tolerability of onabotulinumtoxinA in the treatment of chronic migraine. Eur J Neurol 21:851–859

    Article  PubMed Central  PubMed  Google Scholar 

  • Neeb L, Hellen P, Boehnke C et al (2011) IL-1β stimulates COX-2 dependent PGE2 synthesis and CGRP release in rat trigeminal ganglia cells. PLoS ONE 6:e17360

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Perini F, D’Andrea G, Galloni E et al (2005) Plasma cytokine levels in migraineurs and controls. Headache 45:926–931

    Article  PubMed  Google Scholar 

  • Zhang X, Burstein R, Levy D (2012) Local action of the proinflammatory cytokines IL-1β and IL-6 on intracranial meningeal nociceptors. Cephalalgia 32:66–72

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Parkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, The Smith Tower, Suite 1801 6550 Fannin, Houston, TX, 77030, USA

    José Fidel Baizabal-Carvallo

Authors
  1. José Fidel Baizabal-Carvallo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to José Fidel Baizabal-Carvallo.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Baizabal-Carvallo, J.F. Can the Immunological Response to Botulinum Toxin Trigger Headaches?. Neurotox Res 27, 69–70 (2015). https://doi.org/10.1007/s12640-014-9490-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12640-014-9490-z

Keywords

Search

Navigation