Erratum to: The Role of Autophagy Dysregulation in Manganese-Induced Dopaminergic Neurodegeneration

Erratum to: Neurotox Res (2013) 24:478–490 DOI 10.1007/s12640-013-9392-5

There are two errors in Fig. 2c and Fig. 6e. The correct version of Fig. 2c and Fig. 6e are given in this erratum.

Fig. 2

The effect of manganese on DAergic neurons in immunofluorescence. 8 h, 1, 7, 14, and 28 days after manganese administration, immunofluorescence was conducted to measure TH-immunoreactivity and TH expression. A Location of substantia nigra pars compacta (SNpc). a Scale bar indicates 1,000 μm. b Scale bar indicates 500 μm. c Scale bar indicates 200 μm. B Quantitative analysis of the effect of manganese on DAergic neurons in the ratio of total neurons. *p < 0.05, **p < 0.01 compared with control groups. C The effect of manganese on TH-immunoreactivity. Scale bar indicates 200 μm

Fig. 6

The inhibition of autophagy promotes the short-term effect of Mn on nigral DAergic neurons and apomorphine-induced rotations. After the pretreatment of wortmannin in Mn-exposed rats, immunofluorescence and western blotting were conducted to measure TH-immunoreactivity and the expression of TH protein, and the apomorphine-induced rotations were also observed to measure manganese-induced Daergic neurotoxicity. a Effect of wortmannin on autophagy. b, c Densitometry analysis of Beclin 1 protein levels and LC3 II levels relative to LC3 I (mean ± SD; one-way ANOVA with Newman–Keuls post hoc analysis, *p < 0.05 and **p < 0.01). d Quantitative analysis of the effect of autophagy inhibition before Mn exposure on the apomorphine-induced rotations. e Effect of autophagy inhibition on manganese-induced TH-immunoreactivity change. f Quantitative analysis of the effect of autophagy inhibition on manganese-induced loss of DAergic neurons. *p < 0.05, **p < 0.01 compared with control groups, scale bar indicates 200 μm. g The inhibition of autophagy by wortmannin promotes the short-term effect of manganese on TH expression. h Densitometry analysis of TH levels relative to β-actin was performed after three independent experiments. i Effect of autophagy inhibition on manganese-induced dopamine levels change (mean ± SD; one-way ANOVA with Newman–Keuls post hoc analysis, *p < 0.05 and **p < 0.01)