Neurotoxicity Research

, Volume 24, Issue 4, pp 491–501

Altered Cytokine and BDNF Levels in Autism Spectrum Disorder

  • S. Ricci
  • R. Businaro
  • F. Ippoliti
  • V. R. Lo Vasco
  • F. Massoni
  • E. Onofri
  • G. M. Troili
  • V. Pontecorvi
  • M. Morelli
  • M. Rapp Ricciardi
  • T. Archer
Original Article

DOI: 10.1007/s12640-013-9393-4

Cite this article as:
Ricci, S., Businaro, R., Ippoliti, F. et al. Neurotox Res (2013) 24: 491. doi:10.1007/s12640-013-9393-4

Abstract

The contribution of neuroimmune functioning and brain-derived neurotrophic factor (BDNF) to functional dysregulation in autism spectrum disorder was assessed in 29 patients under treatment in two specialized centers of Basilicata (Chiaromonte and Matera), Southern Italy, through analysis of serum levels of cytokines and BDNF. Elevated levels of the pro-inflammatory cytokine, including interleukin-1, interleukin-6, interleukin-12, interleukin-23, tumor necrosis factor-α and BDNF were observed, regardless of age and gender. Comparisons were made with age- and gender-related healthy controls. The present findings reinforce current notions regarding immunoexcitotoxic mechanisms contributing to the pathophysiology of autistic disorder.

Keywords

AutismImmune systemCytokinesHandicapImmunoexcitotoxicity

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • S. Ricci
    • 1
  • R. Businaro
    • 2
  • F. Ippoliti
    • 3
  • V. R. Lo Vasco
    • 4
  • F. Massoni
    • 1
  • E. Onofri
    • 1
  • G. M. Troili
    • 1
  • V. Pontecorvi
    • 2
  • M. Morelli
    • 2
  • M. Rapp Ricciardi
    • 5
    • 6
  • T. Archer
    • 5
    • 6
  1. 1.Department of Anatomy, Histology, Legal Medicine and OrthopaedicsSapienza UniversityRomeItaly
  2. 2.Department of Medico-Surgical Sciences and BiotechnologiesSapienza UniversityLatinaItaly
  3. 3.Department of Experimental MedicineSapienza UniversityRomeItaly
  4. 4.Department Organi di SensoSapienza UniversityRomeItaly
  5. 5.Department of PsychologyUniversity of GothenburgGothenburgSweden
  6. 6.Department of Psychology, Education and Sports ScienceLinnea UniversityKalmarSweden