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New Strategies in Neuroprotection and Neurorepair

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Abstract

There are currently few clinical strategies in place, which provide effective neuroprotection and repair, despite an intense international effort over the past decades. One possible explanation for this is that a deeper understanding is required of how endogenous mechanisms act to confer neuroprotection. This mini-review reports the proceedings of a recent workshop “Neuroprotection and Neurorepair: New Strategies” (Iguazu Falls, Misiones, Argentina, April 11–13, 2011, Satellite Symposium of the V Neurotoxicity Society Meeting, 2011) in which four areas of active research were identified to have the potential to generate new insights into this field. Topics discussed were (i) metallothionein and other multipotent neuroprotective molecules; (ii) oxidative stress and their signal mediated pathways in neuroregeneration; (iii) neurotoxins in glial cells, and (iv) drugs of abuse with neuroprotective effects.

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Acknowledgments

AKW and GJG acknowledge the support of NH&MRC, MA acknowledges the support of NIH R01 ES07331 and R01 ES10563. YT acknowledges the support of NIH/NIGMS (2SO6GM08016-39). RM acknowledges the support by Grants PI071073 and PNSD from the Spanish MSPS and BFU2010-20664 from the Spanish MICINN. MAC acknowledges support from NIH RO1 AA013568 and T32 AA013527. The workshop “Neuroprotection and Neurorepair: New Strategies” (Iguazu Falls, Misiones, Argentina, April 11–13, 2011) was partially supported by CONICET-Argentina (3715/10) and ANPCYT-Argentina (RC-290/10). The authors wish to thank Mrs. Susana Buglione for excellent bibliographic management.

Conflicts of interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, C1113AAD, Buenos Aires, Argentina

    Marta C. Antonelli

  2. University of New South Wales, School of Medical Sciences, Neuroinflammation Group, Sydney, NSW, Australia

    Gilles J. Guillemin

  3. INSERM, UMRS 975, CRICM, Experimental Therapeutics of Neurodegeneration, Hôpital de la Salpêtrière, 75651, Paris, France

    Rita Raisman-Vozari

  4. Department of Physiology, School of Odontology, FORP, Ribeirão Preto, Brazil

    Elaine A. Del-Bel

  5. Departments of Pediatrics, Pharmacology, and the Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

    Michael Aschner

  6. Department of Molecular Pharmacology & Therapeutics, Loyola University School of Medicine, Maywood, IL, USA

    Michael A. Collins

  7. Department of Pharmacology, College of Medicine, Howard University, Washington, DC, 20059, USA

    Yousef Tizabi

  8. Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC, 28002 and CIBERNED ISCIII, Madrid, Spain

    Rosario Moratalla

  9. Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, 7001, Australia

    Adrian K. West

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  1. Marta C. Antonelli
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  2. Gilles J. Guillemin
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  3. Rita Raisman-Vozari
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  4. Elaine A. Del-Bel
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  5. Michael Aschner
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  6. Michael A. Collins
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  8. Rosario Moratalla
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  9. Adrian K. West
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Correspondence to Marta C. Antonelli.

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Antonelli, M.C., Guillemin, G.J., Raisman-Vozari, R. et al. New Strategies in Neuroprotection and Neurorepair. Neurotox Res 21, 49–56 (2012). https://doi.org/10.1007/s12640-011-9265-8

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