Abstract
The present study was conducted to evaluate the anthelmintic efficacy of crude neem (Azadirachta indica) leaf powder against strongyle infections in cattle. Based on copro-examination, 30 cattle positive for strongyle infection with at least 250 [eggs per gram (EPG) of faeces] were selected and grouped as A, B and C (10 animals/group). Group A and B were treated respectively with fendendazole and neem leaf powder @ 5 and 500 mg/kg body weight, whereas Group C served as infected untreated control. Faecal sample from each animal of these groups was examined on day 0, 7, 14 and 28 post treatments and EPG was determined. The result showed significant decrease (p < 0.05) in EPG in Group A and B after day 7 post treatment but there was no significant variation in terms of EPG in control group. Thus it can be concluded that crude neem leaf powder has anthelmintic property and it can further be studied to isolate the active component to produce herbal anthelminthics.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Akhtar MS, Iqbal Z, Khan MN, Lateef M (2000) Anthelmintic activity of medicinal plants with particular reference to their use in animals in the Indo Pakistan subcontinent. Small Rumin Res 38:99–107
Ali M (2005) Prevalence and treatment trials against Gastrodiscus infestation and its effect on various blood components in horses. M.Sc. (Hons.) thesis, Deptt. Clin. Med. Surg., University of Veterinary and Animal Sciences, Lahore, Pakistan
Baldo RC (2001) Comparative efficacy of pineapple (Ananas comosus) leaves bolus and albendazole against gastrointestinal nematodes of sheep. DVM. University of the Philippines, Department of Vet Parasitol, p 38
Chandrawathani P, Brelin D, Nor FAS, Adnan M, Jamnah O, Rehana AS, Hoglund J, Waller PJ (2002) Evaluation of the neem tree (Azadirachta indica) as a herbal anthelmintic for nematode parasite control in small ruminants in Malaysia. Trop Biomed 19:41–48
Coles GC, Bauer C, Borgsteede FHM, Geerts S, Walker PJ (1992) World Association for the Advancement of Veterinary Parasitology (WAAVP) methods for the detection of anthelmintic resistance. Vet Parasitol 44:35–44
Kaemmerer K, Butenkotter S (1973) The problem of residues in meat of edible domestic animals after application or intake of organophosphatic esters. Residue Rev 46:1–240
Kalesaraj R (1974) Screening of some indeginous plants for anthelmintic action against human Ascaris lumbricoides. Indian J Physiol Pharmacol 19:47–49
Kudom AA, Mensah BA, Botchey MA (2011) Aqueous neem extract versus neem powder on Culex quinquefasciatus: implications for control in anthropogenic habitats. J Insect Sci 11:1–9
Lal J, Chandra S, Sabir M (1976) In vitro anthelmintic of some indigenous medicinal plants on Ascaridia galli worms. Indian J Physiol Pharmacol 20:64–68
Lavie D, Jain MK, Shpan-Gabrielith SR (1967) A locust phagorepellent from two Melia species. Chem Commun 18:910–911
Maff (1977) Manual of Veterinary Parasitological Laboratory Techniques. Technical Bulletin No. 18, Ministry of Agriculture, Fisheries and Food, London, p 129
Mahboob K, Khan JA, Khan MS (2008) Prevalence, chemotherapy and haematology of stronglyosis in horses of district layyah. J Anim Plant Sci 18:117–119
Naganishi K (1975) Structure of the insect antifeedant azadirachtin. In: Runeckles VC (ed) Recent advances in phytochemistry, vol 5. Plenum, New York, pp 283–298
Neogi NC, Baliga PAC, Shrivastava RK (1964) Anthelmintic activity of some indigenous drugs. Indian J Pharmacol 26:37–39
Pietrosemdi S, Olavez R, Montilla T, Campos Z (1999) Empleo de hojas de Neem (Azadirachta indica; A. juss) en control de nematodes gastrointestinales de bovines a pastoreo. Revista de la Facultad de Agronomia 16:220–222
Qiao J, Zou X, Lai D, Yan Y, Wang Q, Li W, Deng S, Xu H, Gu H (2013) Azadirachtin blocks the calcium channel and modulates the cholinergic miniature synaptic current in the central nervous system of Drosophila. Pest Manag Sci. doi:10.1002/ps.3644
Radhakrishnan L, Gomathinayagam Balakrishnan V (2010) Evaluation of anthelmintic effect of Neem (Azadirachta indica) leaves on Haemonchus contortus in goats. Res J Parasitol 5:292–297
Rajakaruna RS, Warnakulasooriya KN (2011) Gastrointestinal parasites in dairy cattle in Kandy district in Sri Lanka. Ann Res J SLSAJ 11:92–99
Ramesh KS, Susan E, Devanand PF (2011) Bioactive constituents and antimicrobial activity of cell cultures of Azadirachta indica. Int J Pharm Bio Sci 2:617–628
Sharma LD, Rhaga HS, Shristava PS (1971) In vitro anthelmintic screening of indigenous medicinal plants against Haemonchus contortus (Rudolphi, 1803) Cobbold., 1898 of sheep and goats. Indian J Anim Res 5:33–38
Shin-Foon C (1984) The active principles and insecticidal properties of some Chinese plants, with special reference to Meliaceae. In Schmutterer and Asher, pp 255–261
Veerakumari L, Priya P (2006) In vitro effect of azadirachtin on the motility and acetylcholinesterase activity of Cotylophoron cotylophorum (Fischoeder, 1901). J Vet Parasitol 20:1–5
Waller PJ (1987) Anthelmintic resistance and future for roundworm control. Vet Parasitol 15:177–191
Waller PJ, Prichard RK (1985) Drug resistance in nematodes. In: Campbell WC, Rcw RS (eds) Chemotherapy of parasitic infections. Phenum, New York, pp 339–362
Acknowledgments
The authors are thankful to D.I., NDVSU, Jabalpur and Dean, College of Veterinary Science, MHOW for proving necessary help for conducting the study.
Author information
Authors and Affiliations
Corresponding author
Additional information
Part of M.V.Sc thesis of first author.
Rights and permissions
About this article
Cite this article
Jamra, N., Das, G., Singh, P. et al. Anthelmintic efficacy of crude neem (Azadirachta indica) leaf powder against bovine strongylosis. J Parasit Dis 39, 786–788 (2015). https://doi.org/10.1007/s12639-014-0423-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12639-014-0423-9