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Preparation and Physicochemical Evaluation of Calcium Silicate/Sodium Silicate Composite Used as a Drug Delivery System for the Low-Dose Drug Atenolol

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Abstract

The purpose of this study is to prepare calcium silicate powder and to develop an optimal formulation based on calcium silicate for low-dose drug delivery. The calcium silicate powder was prepared via the co-precipitation method using calcium nitrate and sodium silicate as precursors. The calcium silicate-based system is composed of three components: calcium silicate, sodium silicate, and citric acid which together are examined as an optimal oral drug delivery system. A model of low-dose antihypertensive drugs, Atenolol, was selected to evaluate the in-vitro drug release from the developed calcium silicate-based system. The properties of the synthesized calcium silicate powder and the calcium silicate-based system were characterized using conventional methods. The results showed fast formation of a pure calcium silicate powder having agglomerated microstructure grains with sizes less than 1.0 μm. The calcium silicate/sodium silicate/citric acid (CSC) composite tablets exhibited a dense structure having a compressive strength of 75 MPa. The in-vitro release test showed that Atenolol released sequentially over 150 min without burst release kinetics. Therefore, these results confirmed that CSC composite tablets have optimal composition and physicochemical characteristics as promising economic degradable carriers for low-dose drugs.

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Authors and Affiliations

  1. Biophysics Lab, Physics Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt

    R. Morsy

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Morsy, R. Preparation and Physicochemical Evaluation of Calcium Silicate/Sodium Silicate Composite Used as a Drug Delivery System for the Low-Dose Drug Atenolol. Silicon 10, 609–613 (2018). https://doi.org/10.1007/s12633-016-9501-1

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  • DOI: https://doi.org/10.1007/s12633-016-9501-1

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