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Aza-Michael Addition of γ-Aminopropylsilatranes to Substituted N-Phenylmaleimides: Design and Synthesis of a Heterocyclic Amine Receptor and Their Preliminary Antimicrobial Studies

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Abstract

An efficient method for C-N bond formation via aza-Michael addition of γ-aminopropylsilatranes to substituted N-phenylmaleimides under mild conditions is described. The five receptors enclosing the maleimide moiety have been synthesized by the aza-Michael addition to strong nucleophile γ-aminopropylsilatrane producing silatranes possessing substituted N-phenylsuccinimide at the axial position without any catalyst. All the compounds have been characterized by elemental analysis, spectroscopic techniques and thermo-gravimetric analysis. The synthesized compounds have been screened for possible antimicrobial properties and results have shown modest activity.

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Authors and Affiliations

  1. Department of Chemistry, Panjab University, Chandigarh, 160014, India

    Gurjaspreet Singh & Amandeep Saroa

  2. Centre for Microbial Biotechnology, Panjab University, Chandigarh, 160014, India

    Rupinder Tewari & Parvinder Kaur

Authors
  1. Gurjaspreet Singh
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  2. Amandeep Saroa
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  3. Rupinder Tewari
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  4. Parvinder Kaur
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Correspondence to Gurjaspreet Singh.

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Singh, G., Saroa, A., Tewari, R. et al. Aza-Michael Addition of γ-Aminopropylsilatranes to Substituted N-Phenylmaleimides: Design and Synthesis of a Heterocyclic Amine Receptor and Their Preliminary Antimicrobial Studies. Silicon 9, 495–501 (2017). https://doi.org/10.1007/s12633-014-9245-8

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  • DOI: https://doi.org/10.1007/s12633-014-9245-8

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