, Volume 17, Issue 5, pp 456-460
Date: 03 Dec 2012

Low vitamin and carotenoid levels are related to cerebral white matter lesions

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Objectives: Purpose

To determine the effects of vitamins and carotenoids on brain white matter lesions (WMLs), we examined the associations between WMLs with vitamin and carotenoid levels in Japanese middle-aged and elderly subjects.

Subjects and methods

Four-hundred and sixty-nine healthy participants (male = 317; female = 152) that underwent medical examinations were examined. Deep white matter lesions (DWLs) were detected via magnetic resonance imaging (MRI) in 39 subjects. We evaluated the effects of vitamin and carotenoid levels on DWLs via logistic regression analysis.


Lower gamma-tocopherol levels were significantly associated with DWLs in all subjects. While lower gamma-tocopherol and vitamin C levels were significantly associated with DWLs in males, lower delta-tocopherol levels were associated with DWLs in females. The associations between DWLs and lower gamma- and delta-tocopherol and vitamin C levels were independent of age, hypertension, or smoking. However, the associations between DWLs and lower alfatocopherol were not significant following adjustments for smoking.


Lower carotenoid and vitamin levels were independently associated with cerebral DWLs in Japanese subjects.