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Effect of an 8-weeks aerobic training program in elderly on oxidative stress and Hsp72 expression in leukocytes during antioxidant supplementation

  • JNHA: Clinical Trials and Aging
  • Published:
The journal of nutrition, health & aging

Abstract

Objective

To investigate the effect of aerobic training in the context of antioxidant supplementation on systemic oxidative stress and leukocytes heat shock protein (Hsp)72 expression in the elderly.

Design

Sixteen septuagenarians (8 males and 8 females, mean age 74.6) were supplemented with Vitamin C and E (respectively 500 and 100mg per day) and randomly assigned either to sedentary (AS) or individualized aerobically trained (AT) group for 8 weeks.

Methods

Plasma Vitamin C and E concentrations and aerobic fitness, as well as resting and post graded exercise (GXT) Hsp72 expression in leukocytes, plasma levels of thiobarbituric acid reactive substances (TBARS) and advanced oxidation protein product (AOPP) were measured pre and post training / supplementation.

Results

At the end of the intervention, the two groups showed a significant increase in resting plasma vitamin C and E (approximately 50 and 20% increase respectively) and a significant decrease in both resting and post GXT plasma TBARS and AOPP (approximately 25 and 20% decrease respectively). These changes were of similar magnitude in the two groups. The reduced oxidative stress was concomitant with a 15% decreased expression of Hsp72 in monocytes and granulocytes in both groups.

Conclusion

This study provides evidence that in elderly, increased concentration of antioxidant vitamins C and E is associated with a reduction in oxidative stress and leukocytes Hsp72. In this context, 8 weeks of aerobic training has no impact on oxidative stress or leukocytes Hsp72 expression in elderly people.

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Authors and Affiliations

  1. School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia

    David Simar

  2. INSERM, ERI 25 “Muscle and Pathologies”, Hôpital A. de Villeneuve, 34295, Montpellier, France

    D. Malatesta

  3. Département de Biochimie, Hôpital Lapeyronie, 34295, Montpellier, France

    E. Mas & M. Delage

  4. Exercise, Health & Performance Research Group, Faculty of Health Sciences, The University of Sydney, Sydney, Australia

    C. Caillaud

  5. Institute of Sport Sciences (ISSUL), Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

    D. Malatesta

  6. School of Medical Science, Faculty of Medicine, University of New South Wales, Wallace Wurth Building, Sydney, NSW, 2052, Australia

    David Simar

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  1. David Simar
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Correspondence to David Simar.

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Simar, D., Malatesta, D., Mas, E. et al. Effect of an 8-weeks aerobic training program in elderly on oxidative stress and Hsp72 expression in leukocytes during antioxidant supplementation. J Nutr Health Aging 16, 155–161 (2012). https://doi.org/10.1007/s12603-011-0106-5

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  • DOI: https://doi.org/10.1007/s12603-011-0106-5

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