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Antiviral Potential of Lactic Acid Bacteria and Their Bacteriocins

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Abstract

Emerging resistance to antiviral agents is a growing public health concern worldwide as it was reported for respiratory, sexually transmitted and enteric viruses. Therefore, there is a growing demand for new, unconventional antiviral agents which may serve as an alternative to the currently used drugs. Meanwhile, published literature continues shedding the light on the potency of lactic acid bacteria (LAB) and their bacteriocins as antiviral agents. Health-promoting LAB probiotics may exert their antiviral activity by (1) direct probiotic–virus interaction; (2) production of antiviral inhibitory metabolites; and/or (3) via stimulation of the immune system. The aim of this review was to highlight the antiviral activity of LAB and substances they produce with antiviral activity.

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Acknowledgments

The authors would like to thank Dr. Delphine Caly for critical reading of the manuscript. I.A.K. received a scholar fellowship from Lille 1 University (France) and AZM Center (Lebanon) for his PhD training.

Conflict of interest

The authors declare that they do not have any conflict of interest.

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Authors and Affiliations

  1. Institut Charles Viollette - Université Lille 1, Bâtiment Polytech-Lille, Cité Scientifique, Avenue Paul Langevin, 59655, Villeneuve d’Ascq Cedex, France

    I. Al Kassaa, N. E. Chihib & D. Drider

  2. Laboratoire de Microbiologie Santé et Environnement, Rue Mitein, AZM Center of Biotechnologie, EDST-Université Libanaise at Tripoli, Tripoli, Lebanon

    I. Al Kassaa & M. Hamze

  3. CHRU Lille Laboratoire de Virologie EA3610, Université Lille 2 Faculté de Médecine, 59120, Loos-lez-Lille, France

    D. Hober

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  1. I. Al Kassaa
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Al Kassaa, I., Hober, D., Hamze, M. et al. Antiviral Potential of Lactic Acid Bacteria and Their Bacteriocins. Probiotics & Antimicro. Prot. 6, 177–185 (2014). https://doi.org/10.1007/s12602-014-9162-6

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