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Right- and left-sided carcinoid heart disease without intracardiac shunting

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Abstract

We present a case of a 54-year-old man with carcinoid heart disease and mitral valve involvement. He had hepatic carcinoid with an extremely elevated urinary excretion of 5-hydroxyindole acetic acid and was referred to our division for shortness of breath and leg edema. Transthoracic echocardiography showed the thickened and retracted tricuspid valve leaflets and severe tricuspid regurgitation. Moderate mitral regurgitation was observed, with the involvement of mitral valve leaflets. A patent foramen ovale was not detected on transesophageal echocardiography. The extremely high concentration of circulating serotonin and/or other vasoactive substances may have contributed to left- as well as right-sided carcinoid heart disease.

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References

  1. Pellikka PA, Tajik AJ, Khandheria BK, et al. Carcinoid heart disease. Clinical and echocardiographic spectrum in 74 patients. Circulation. 1993;87:1188–96.

    Article  PubMed  CAS  Google Scholar 

  2. Møller JE, Connolly HM, Rubin J, et al. Factors associated with progression of carcinoid heart disease. N Engl J Med. 2003;348:1005–15.

    Article  PubMed  Google Scholar 

  3. Robiolio PA, Rigolin VH, Wilson JS, et al. Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography. Circulation. 1995;92:790–5.

    Article  PubMed  CAS  Google Scholar 

  4. Bhattacharyya S, Toumpanakis C, Caplin ME, et al. Analysis of 150 patients with carcinoid syndrome seen in a single year at one institution in the first decade of the twenty-first century. Am J Cardiol. 2008;101:378–81.

    Article  PubMed  Google Scholar 

  5. Connolly HM, Schaff HV, Mullany CJ, et al. Surgical management of left-sided carcinoid heart disease. Circulation. 2001;104:I36–40.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Go Igawa.

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Igawa, G., Ishida, K., Matsubara, K. et al. Right- and left-sided carcinoid heart disease without intracardiac shunting. J Echocardiogr 10, 135–137 (2012). https://doi.org/10.1007/s12574-012-0138-9

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  • DOI: https://doi.org/10.1007/s12574-012-0138-9

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