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The Experimental Research (In Vitro) of Carrageenans and Fucoidans to Decrease Activity of Hantavirus

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Abstract

The effect of carrageenans and fucoidans on the activity of Hantavirus is studied. It has been found that among carrageenans a significant antiviral effect is exerted by the ι-type, which decreases the viral titer by 2.5 log focus forming units per mL; among fucoidans, by a preparation from Laminaria cichorioides, which reduces the number of infected cells from 27.0 to 5.3 after pretreatment of both the macrophage culture and Hantavirus. The antiviral effect of fucoidan from Laminaria japonica is shown to grow in direct proportion to the increase of dose of the preparation.

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Acknowledgments

This work was supported by the Russian Science Foundation (Project No. 14-50-00034).

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Authors and Affiliations

  1. School of Natural Sciences, Far Eastern Federal University (FEFU), Vladivostok, Russia

    Stanislav N. Pavliga & Vasiliy Yu. Tsygankov

  2. School of Biomedicine, Far Eastern Federal University (FEFU), 8 Sukhanova str., 690000, Vladivostok, Russia

    Vasiliy Yu. Tsygankov

  3. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia

    Galina G. Kompanets

Authors
  1. Stanislav N. Pavliga
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  2. Galina G. Kompanets
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  3. Vasiliy Yu. Tsygankov
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Correspondence to Vasiliy Yu. Tsygankov.

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Pavliga, S.N., Kompanets, G.G. & Tsygankov, V.Y. The Experimental Research (In Vitro) of Carrageenans and Fucoidans to Decrease Activity of Hantavirus. Food Environ Virol 8, 120–124 (2016). https://doi.org/10.1007/s12560-016-9233-9

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  • DOI: https://doi.org/10.1007/s12560-016-9233-9

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