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Role of micronutrients for healthy ageing – moving towards collaborative personalized nutrition

  • Published:
Bijblijven

Samenvatting (vertaling)

Een verhoogde levensverwachting betekent niet noodzakelijkerwijs een gezonde oude dag. Wie oud wordt, loopt meer kans op een chronische ziekte als voornaamste oorzaak van beperkingen, aandoeningen en sterfte op de oude dag in de moderne samenleving. Een lifestylefactor die van invloed is op gezond ouder worden en die zich nog laat bijstellen, is voeding. Onderzoek naar patronen in voedselinname en nutriëntenstatus maakt duidelijk dat populaties in veel landen wereldwijd, waaronder Nederland, een tekort vertonen aan essentiële mineralen en vitaminen als micronutriënten. Dit probleem kan op verschillende niveaus worden aangepakt: voorlichting over voldoende nutriëntinname aan de algemene bevolking (algemene preventie), adviseren van hogere inname aan risicogroepen, zoals zwangeren en zuigelingen (geïndiceerde preventie) en ditzelfde advies aan dragers van genetische risicofactoren voor bepaalde ziekten (ziektegerelateerde preventie). Tegelijkertijd is het van belang ervoor te zorgen dat de dagelijkse energie-inname, tegenwoordig doorgaans hoger dan het aanbevolen niveau, wordt aangepast aan geslacht, leeftijd en levensstijl. Apps waarmee het publiek de eigen gezondheid kan beoordelen, vormen een eerste stap naar het actief motiveren en aansporen van het publiek om tot een gezondere leefwijze te komen. Een doeltreffende aanpak van de gesignaleerde micronutriëntdeficiëntie kan niet zonder de samenwerking van gezondheidswetenschappers, de industrie en de zorgautoriteiten.

Abstract

An increased life expectancy does not necessarily imply leading a healthy life as a senior. There is an increased risk of developing noncommunicable diseases, the main cause of impairments and mortality in modern society. Nutrition is one of the modifiable lifestyle factors related to healthy ageing. Food intake surveys and nutrition mapping exercises reveal that populations in many countries worldwide, including that of the Netherlands, suffer from inadequate levels of micronutrients, i.e. essential minerals and vitamins. Tackling this problem may occur at different levels: advocating adequate intake levels in the general population (general prevention), advising increased intake levels for risk groups, e.g. pregnant women and infants (indicated prevention) and advising increased intake levels for those at genetic risk for certain diseases (disease-related prevention). Equally important, it should be ensured that energy intake levels, currently commonly exceeding recommended levels, are appropriate for gender, age and lifestyle. Mobile applications allowing individuals to assess their health are a first step in empowering and encouraging the public to actively participate in a healthier life. To further facilitate this and target micronutrient deficiency, future efforts should involve collaboration between health scientists, the industry and health authorities.

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Literatuur

  • Ames B N. Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci U S A 2006;103(47), 17589–17594. doi: 10.1073/pnas.0608757103

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Brouwer-Brolsma E M, Bischoff-Ferrari H A, Bouillon R Feskens E J, Gallagher C J, Hypponen, E Groot L C de. Vitamin D: do we get enough? A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe. Osteoporos Int 2013; 24(5), 1567–1577. doi: 10.1007/s00198-012-2231-3

    Article  PubMed  CAS  Google Scholar 

  • Bryce J, Coitinho D, Darnton-Hill, I, Pelletier D, Pinstrup-Andersen P, Maternal Child Undernutrition Study G. Maternal and child undernutrition: effective action at national level. Lancet 2008;371(9611), 510–526. doi: 10.1016/S0140-6736(07)61694-8

    Article  PubMed  Google Scholar 

  • Camargo C A, Jr, Rifas-Shiman S L, Litonjua A A, Rich-Edwards J W, Weiss S T, Gold D R, Gillman M W. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr 2007;85(3), 788–795.

    PubMed  CAS  Google Scholar 

  • Cohen D A. Obesity and the built environment: changes in environmental cues cause energy imbalances. Int J Obes (Lond) 2008;32 Suppl 7, S137–142. doi: 10.1038/ijo.2008.250

    Article  Google Scholar 

  • Costacou T, Ferrell R E, & Orchard T J. Haptoglobin genotype: a determinant of cardiovascular complication risk in type 1 diabetes 2008. Diabetes, 57(6), 1702–1706. doi: 10.2337/db08-0095

    Article  PubMed  CAS  Google Scholar 

  • DO-HEALTH. VitaminD3-Omega3-Home Exercise-HeALTHy Ageing and Longevity Trial. Retrieved 26 May, 2014, from http://do-health.eu/wordpress/project/study-description/

  • Dysken M W, Sano M, Asthana S, Vertrees J E, Pallaki M, LlorenteM, Guarino P D. Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA 2014;311(1), 33–44. doi: 10.1001/jama.2013.282834

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • food4me.org. Retrieved 26 May, 2014, from http://www.food4me.org

  • Food and Agriculture Organization of the United Nations. Retrieved 26 May, 2014, from http://www.fao.org/hunger/en/ - jfmulticontent_c130584–2

  • Health Council of the Netherlands. (2012). Evaluation of dietary reference values for vitamin D.

  • Heaney R P. Dairy intake, dietary adequacy, and lactose intolerance. Adv Nutr 2013;4(2), 151–156. doi: 10.3945/an.112.003368

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl D A, Hoffmann K. A systematic review of vitamin D status in populations worldwide. Br J Nutr 2014;111(1), 23–45. doi: 10.1017/S0007114513001840

    Article  PubMed  CAS  Google Scholar 

  • Ho L, Leeuwen R van, Witteman J C, Duijn, C M van, Uitterlinden A G, Hofman A, Klaver C C. Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and omega-3 fatty acids: the Rotterdam study. Arch Ophthalmol 2011; 129(6), 758-766. doi: 10.1001/archophthalmol 2011;141

    Article  Google Scholar 

  • Holick M F, Binkley N C, Bischoff-Ferrari H A, Gordon C M, Hanley D A, Heaney R P, Weaver C M. Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J Clin Endocrinol Metab 2012;97(4), 1153–1158. doi: 10.1210/jc.2011-2601

    Article  PubMed  CAS  Google Scholar 

  • Holick M F, Binkley N C, Bischoff-Ferrari H A, Gordon C M, Hanley D A, Heaney R P. Endocrine, S. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96(7), 1911–1930. doi: 10.1210/jc.2011-0385

    Article  PubMed  CAS  Google Scholar 

  • Hu F B, Li T Y, Colditz G A, Willett W C, & Manson J E. Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA 2003;289(14), 1785-1791. doi: 10.1001/jama 2003;289.14.1785

    Article  PubMed  Google Scholar 

  • Institute for Health Metrics and Evaluation. Global Burden of Diseases Profile: Netherlands. Retrieved 26 May, 2014, from http://www.healthdata.org/sites/default/files/files/country_profiles/GBD/ihme_gbd_country_report_netherlands.pdf

  • Kirkwood T B. A systematic look at an old problem. Nature 2008;451(7179), 644–647. doi: 10.1038/451644a

    Article  PubMed  Google Scholar 

  • Lappe J M, Travers-Gustafson D, Davies K M, Recker R R, & Heaney R P. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007;85(6), 1586–1591.

    PubMed  CAS  Google Scholar 

  • Li K, Kaaks R, Linseisen J, & Rohrmann S. Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg). Heart 2012; 98(12), 920–925. doi: 10.1136/heartjnl-2011-301345

    Article  PubMed  CAS  Google Scholar 

  • Lytle L A, Himes J H, Feldman H, Zive M, Dwyer J, Hoelscher D, Yang, M. Nutrient intake over time in a multi-ethnic sample of youth. Public Health Nutr 2002;5(2), 319–328. doi: 10.1079/PHN2002255

    Article  PubMed  Google Scholar 

  • Marie Curie Agein Network Marriage. Retrieved 26 May, 2014, from http://ageingnetwork.eu

  • Martin L J, Lee S Y, Couch S C, Morrison J, & Woo J G. Shared genetic contributions of fruit and vegetable consumption with BMI in families 20 y after sharing a household. Am J Clin Nutr 2011;94(4), 1138–1143. doi: 10.3945/ajcn.111.015461

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Milman U, Blum S, Shapira C, Aronson D, Miller-Lotan R, Anbinder Y, Levy A P (2008). Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: a prospective double-blinded clinical trial. Arterioscler Thromb Vasc Biol 2008;28(2), 341–347. doi: 10.1161/ATVBAHA.107.153965

    PubMed  CAS  Google Scholar 

  • National Institute of Child Health and Human Development. Phenylketonuria (PKU). Retrieved 26May, 2014, from http://www.nichd.nih.gov/health/topics/pku/conditioninfo/Pages/default.aspx

  • Obican S G, Finnell R H, Mills J L, Shaw G M, & Scialli A R. Folic acid in early pregnancy: a public health success story. FASEB J 2010;24(11), 4167–4174. doi: 10.1096/fj.10-165084

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Persson L A., Arifeen S, Ekstrom E C, Rasmussen K M, Frongillo E A, Yunus M, & Team M. I. S. (2012). Effects of prenatal micronutrient and early food supplementation on maternal hemoglobin, birth weight, and infant mortality among children in Bangladesh: the MINIMat randomized trial. JAMA 2012;307(19), 2050–2059. doi: 10.1001/jama.2012.4061

    Article  PubMed  CAS  Google Scholar 

  • Qawasmi A, Landeros-Weisenberger A, Leckman J F, & Bloch M H. Meta-analysis of long-chain polyunsaturated fatty acid supplementation of formula and infant cognition. Pediatrics 2012;129(6), 1141–1149. doi: 10.1542/peds.2011-2127

    Article  PubMed  PubMed Central  Google Scholar 

  • Salomon J A, Wang H, Freeman M K, Vos T, Flaxman A D, Lopez A D, & Murray C J. Healthy life expectancy for 187 countries, 1990-2010: a systematic analysis for the Global Burden Disease Study 2010. Lancet 2012;380(9859), 2144–2162. doi: 10.1016/S0140-6736(12)61690-0

    Article  PubMed  Google Scholar 

  • San-Cristobal R, Milagro F I, & Martinez J A. Future challenges and present ethical considerations in the use of personalized nutrition based on genetic advice. J Acad Nutr Diet 2013;113(11), 1447–1454. doi: 10.1016/j.jand.2013.05.028

    Article  PubMed  Google Scholar 

  • Touvier M, Chan D S, Lau R, Aune D, Vieira R, Greenwood D C, Norat T. Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 2011;20(5), 1003–1016. doi: 10.1158/1055-9965.EPI-10–1141

    Article  PubMed  CAS  Google Scholar 

  • Troesch B, Hoeft B, McBurney M, Eggersdorfer M, & Weber P. Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries. Br J Nutr 2012;108(4), 692–698. doi: 10.1017/S0007114512001808

    Article  PubMed  CAS  Google Scholar 

  • Ommen B van, Fairweather-Tait, S, Freidig A, Kardinaal A, Scalbert A, & Wopereis S. A network biology model of micronutrient related health. Br J Nutr 2008;99 Suppl 3, S72–80. doi: 10.1017/S0007114508006922

    PubMed  Google Scholar 

  • Rossum C T M van, Fransen H P, Verkaik-Kloosterman J, Buurma-Rethans E J M, & Ocke´ M C. Dutch national food consumption survey 2007–2011

  • Virmani A, Pinto L, Binienda Z, & Ali S. Food, nutrigenomics, and neurodegeneration-neuroprotection by what you eat! Mol Neurobiol 2013;48(2), 353–362. doi: 10.1007/s12035-013-8498-3

    Article  PubMed  CAS  Google Scholar 

  • Voedingscentrum. Richtlijnen voedselkeuze 2011;1-66).WHO, www.who.int/nutgrowthdb/jme_unicef_who_wb.pdf

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Professor for Healthy Ageing, University Medical Center Groningen

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Eggersdorfer, M. Role of micronutrients for healthy ageing – moving towards collaborative personalized nutrition. Bijblijven 30, 63–70 (2014). https://doi.org/10.1007/s12414-014-0047-0

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