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Respiratory motion reduction with a dual gating approach in myocardial perfusion SPECT: Effect on left ventricular functional parameters

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Respiratory motion (RM) complicates the analysis of myocardial perfusion (MP) single-photon emission computed tomography (SPECT) images. The effects of RM on left ventricular (LV) functional variables have not been thoroughly investigated.

Methods and results

Thoracic electrical bioimpedance and electrocardiographic signals were recorded from eighteen patients undergoing the rest phase of a 1-day stress/rest cardiac-gated MP-SPECT examination. The signals and list-mode emission data were retrospectively processed to yield standard cardiac- and dual-gated (respiratory and cardiac gating) image sets applying a novel algorithm. LV volume, MP, shape index (SI), wall motion (WM), wall thickening (WT), and phase analysis parameters were measured with Quantitative Perfusion SPECT/Quantitative Gated SPECT software (Cedars-Sinai Medical Center). Image quality was evaluated by three experienced physicians. Dual gating increased LV volume (77.1 ± 26.8 vs 79.8 ± 27.6 mL, P = .006) and decreased SI (0.57 ± 0.05 vs 0.56 ± 0.05, P = .036) and global WT (39.0 ± 11.8% vs 36.9 ± 9.4%, P = .034) compared to cardiac gating, but did not significantly alter perfusion, WM or phase analysis parameters or image quality (P > .05).

Conclusions

RM reduction has an effect on LV volume, shape, and WT parameters. RM exerts no significant effect on phase analysis parameters.

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Abbreviations

LV:

Left ventricular

MP:

Myocardial perfusion

RM:

Respiratory motion

SI:

Shape index

SPECT:

Single-photon emission computed tomography

WM:

Wall motion

WT:

Wall thickening

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Acknowledgments

The study was supported by Kuopio University Hospital (VTR, Project 5031351), University of Eastern Finland (The Doctoral Programme in Science, Technology and Computing), and by the Academy of Finland (Finnish Centre of Excellence in Inverse Problems Research, Project Number 250215). The authors express thanks to Pekka Tiihonen, PhD, for providing the pulse generator for the examinations, Owen Dillon, BSc(Hons), for guidance in the image registration code optimization, and Ewen MacDonald, PharmD, and Gerald Netto, PhD, for linguistic advice.

Disclosure

The authors have nothing to disclose.

Author information

Authors and Affiliations

  1. Department of Applied Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland

    Matti J. Kortelainen MSc, Marko J. Vauhkonen PhD & Mikko A. Hakulinen PhD

  2. Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland

    Matti J. Kortelainen MSc, Marja K. Hedman MD, PhD, Juanita Niño Quintero MD & Mikko A. Hakulinen PhD

  3. Cancer Center, Kuopio University Hospital, Kuopio, Finland

    Tuomas M. Koivumäki PhD

  4. Heart Center, Kuopio University Hospital, Kuopio, Finland

    Marja K. Hedman MD, PhD & Satu T. J. Kärkkäinen MD, PhD

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  1. Matti J. Kortelainen MSc
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  2. Tuomas M. Koivumäki PhD
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Correspondence to Matti J. Kortelainen MSc.

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Kortelainen, M.J., Koivumäki, T.M., Vauhkonen, M.J. et al. Respiratory motion reduction with a dual gating approach in myocardial perfusion SPECT: Effect on left ventricular functional parameters. J. Nucl. Cardiol. 25, 1633–1641 (2018). https://doi.org/10.1007/s12350-017-0844-9

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  • DOI: https://doi.org/10.1007/s12350-017-0844-9

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