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Sources of variability in the measurement of perfusion defect size using commercially available software programs: Are there gender differences?

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Journal of Nuclear Cardiology Aims and scope

Abstract

We recently showed that Quantitative Perfusion SPECT (QPS), Emory Cardiac Toolbox (ECTb) and 4-Dimension-Myocardial SPECT (4DM) yielded discordant results in the assessment of perfusion defect size (PDS) in patients with known or suspected coronary artery disease. In this report, we examined the sources of variability in the measurement of PDS using ECTb (VarECTb), 4DM (Var4DM) and QPS (VarQPS) and found that gender is a source of variability in the assessment of PDS. In 120 patients, VarECTb was lower in men, compared with women, whereas Var4DM and VarQPS were similar between both genders. Among men, VarECTb was lowest, compared with VarQPS and Var4DM, whereas, VarECTb, VarQPS, and Var4DM were not different among women. Future studies should account for gender differences when comparing the 3 software programs.

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References

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Authors and Affiliations

  1. Division of Cardiovascular Disease, University of Alabama at Birmingham, Lyons Harrison Research Building 306, 1720 2nd AV S, Birmingham, AL, 35294, USA

    Sameer Ather MD, PhD, FACC, Ami E. Iskandrian MD, MACC, MASNC & Fadi G. Hage MD, FACC, FASH, FASNC

  2. Section of Cardiology, Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA

    Sameer Ather MD, PhD, FACC & Fadi G. Hage MD, FACC, FASH, FASNC

Authors
  1. Sameer Ather MD, PhD, FACC
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  2. Ami E. Iskandrian MD, MACC, MASNC
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  3. Fadi G. Hage MD, FACC, FASH, FASNC
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Corresponding author

Correspondence to Sameer Ather MD, PhD, FACC.

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Funding

SA is supported by intramural Frommeyer Fellowship in Investigative Medicine.

All editorial decisions for this article, including selection of reviewers and the final decision, were made by guest editor Alberto Cuocolo, MD.

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Ather, S., Iskandrian, A.E. & Hage, F.G. Sources of variability in the measurement of perfusion defect size using commercially available software programs: Are there gender differences?. J. Nucl. Cardiol. 24, 1089–1093 (2017). https://doi.org/10.1007/s12350-016-0679-9

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  • DOI: https://doi.org/10.1007/s12350-016-0679-9

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