Abstract
Background
While 18F-fluorodeoxyglucose and 18F-sodium fluoride with positron emission tomography relate with inflammation and calcification, their role in the assessment of patients with Takayasu arteritis has not yet been studied.
Methods
We present 5 patients with suspected active metabolic disease who underwent PET with 18F-fluorodeoxyglucose and 18F-sodium fluoride in order to explore the locations and correlations of 18F-fluorodeoxyglucose and 18F-sodium fluoride uptakes. Diagnosis of metabolic active disease was based on 18F-fluorodeoxyglucose uptake.
Results
We studied 3 female patients and 2 male patients. Median age was 29 years (min: 19 max: 63). In areas with atherosclerotic plaques, we found a negative correlation between 18F-sodium fluoride and 18F-fluorodeoxyglucose uptakes (r = −0.78) (P = .001). Meanwhile, in areas with only metabolic active disease, we found a positive correlation between 18F-sodium fluoride and 18F-fluorodeoxyglucose uptakes (r = 0.94) (P = .019).
Conclusions
In Takayasu arteritis, 18F-sodium fluoride uptake can document different stages of metabolic disease, even in the absence of active metabolic disease or symptoms.
This is a preview of subscription content, log in via an institution to check access.
Abbreviations
- PET:
-
Positron emission tomography
- mCi:
-
Milicurie
- 18F-FDG:
-
18F-Fluorodeoxyglucose
- 18F-NaF:
-
18F-sodium fluoride
References
Seyahi E, Ucgul A, Cebi Olgun D, Ugurlu S, Akman C, Tutar O, et al. Aortic and coronary calcifications in Takayasu arteritis. Semin Arthritis Rheum 2013;43:96-104. doi:10.1016/j.semarthrit.2012.11.001.
Soussan M, Nicolas P, Schramm C, Katsahian S, Pop G, Fain O, et al. Management of large-vessel vasculitis with FDG-PET: A systematic literature review and meta-analysis. Medicine 2015;94:1-8. doi:10.1097/MD.0000000000000622.
Dweck MR, Chow MWL, Joshi NV, Williams MC, Jones C, Fletcher AM, et al. Coronary arterial 18F-sodium fluoride uptake: A novel marker of plaque biology. J Am Coll Cardiol 2012;59:1539-48. doi:10.1016/j.jacc.2011.12.037.
Joshi NV, Vesey AT, Williams MC, Shah AS, Calvert PA, Craighead FH, et al. 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: A prospective clinical trial. Lancet 2014;383:705-13. doi:10.1016/S0140-6736(13)61754-7.
Rudd JHF, Myers KS, Bansilal S, Machac J, Woodward M, Fuster V, et al. The relationships between regional arterial inflammation, calcification, risk factors and biomarkers—A prospective FDG PET/CT imaging study. Imaging 2011;2:107-15. doi:10.1161/CIRCIMAGING.108.811752.The.
Abdelbaky A, Corsini E, Figueroa AL, Fontanez S, Subramanian S, Ferencik M, et al. Focal arterial inflammation precedes subsequent calcification in the same location: A longitudinal FDG-PET/CT study. Circ Cardiovasc Imaging 2013;6:747-54. doi:10.1161/CIRCIMAGING.113.000382.
Ohigashi H, Haraguchi G, Konishi M, Tezuka D, Kamiishi T, Ishihara T, et al. Improved prognosis of Takayasu arteritis over the past decade. Circ J 2012;76:1004-11. doi:10.1253/circj.CJ-11-1108.
Isobe M. Takayasu arteritis revisited: Current diagnosis and treatment. Int J Cardiol 2013;168:3-10. doi:10.1016/j.ijcard.2013.01.022.
Gujadhur A, Smith ER, Mcmahon LP, Spanger M, Chuen J, Holt SG. Large vessel calcification in Takayasu arteritis. Intern Med J 2013;43:584-7. doi:10.1111/imj.12116.
Danve A, O’Dell J. The role of 18F fluorodeoxyglucose positron emission tomography scanning in the diagnosis and management of systemic vasculitis. Int J Rheum Dis 2015. doi:10.1111/1756-185X.12713.
Disclosure
Nothing to disclose.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Alexanderson-Rosas, E., Monroy-Gonzalez, A.G., Juarez-Orozco, L.E. et al. [18F]-Sodium fluoride uptake in Takayasu arteritis. J. Nucl. Cardiol. 24, 1674–1679 (2017). https://doi.org/10.1007/s12350-016-0627-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12350-016-0627-8