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Absolute quantification of myocardial blood flow

  • Review Article
  • Published:
Journal of Nuclear Cardiology Aims and scope

Abstract

With the increasing availability of positron emission tomography (PET) myocardial perfusion imaging, the absolute quantification of myocardial blood flow (MBF) has become popular in clinical settings. Quantitative MBF provides an important additional diagnostic or prognostic information over conventional visual assessment. The success of MBF quantification using PET/computed tomography (CT) has increased the demand for this quantitative diagnostic approach to be more accessible. In this regard, MBF quantification approaches have been developed using several other diagnostic imaging modalities including single-photon emission computed tomography, CT, and cardiac magnetic resonance. This review will address the clinical aspects of PET MBF quantification and the new approaches to MBF quantification.

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Abbreviations

CMR:

Cardiac magnetic resonance

CT:

Computed tomography

MBF:

Myocardial blood flow

MFR:

Myocardial blood flow reserve

PET:

Positron emission tomography

SPECT:

Single-photon emission computed tomography

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Acknowledgments

We thank Yuuki Tomiyama, MSc, and Eriko Suzuki for their technical support. This manuscript has been reviewed by a North American English-language professional editor, Ms. Holly Beanlands. The authors also thank Ms. Holly Beanlands for critical reading of the manuscript.

Disclosures

The authors’ work presented in this article was supported in part by grants from the Innovation Program of the Japan Science and Technology Agency.

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Authors and Affiliations

  1. Diagnostic and Therapeutic Nuclear Medicine, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-Ku, Chiba, 263-8555, Japan

    Keiichiro Yoshinaga MD, PhD, FACC, FASNC

  2. Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Osamu Manabe MD, PhD & Nagara Tamaki MD, PhD

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  1. Keiichiro Yoshinaga MD, PhD, FACC, FASNC
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  2. Osamu Manabe MD, PhD
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  3. Nagara Tamaki MD, PhD
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Correspondence to Nagara Tamaki MD, PhD.

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Yoshinaga, K., Manabe, O. & Tamaki, N. Absolute quantification of myocardial blood flow. J. Nucl. Cardiol. 25, 635–651 (2018). https://doi.org/10.1007/s12350-016-0591-3

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