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Prognostic value of the cadmium-zinc-telluride camera: A comparison with a conventional (Anger) camera

  • Original Article
  • Published:
Journal of Nuclear Cardiology Aims and scope

Abstract

Background

New multipinhole cadmium-zinc-telluride (CZT) cameras allow for faster imaging and lower radiation doses for single photon emission computed tomography (SPECT) studies, but assessment of prognostic ability is necessary.

Methods and Results

We collected data from all myocardial SPECT perfusion studies performed over 15 months at our institution, using either a CZT or conventional Anger camera. A Cox proportional hazards model was used to assess the relationship between camera type, imaging results, and either death or myocardial infarction (MI). Clinical variables including age, sex, body mass index (BMI), and historical risk factors were used for population description and model adjustments. We had 2,088 patients with a total of 69 deaths and 65 MIs (122 events altogether). A 3% increase in DDB (difference defect burden) represented a 12% increase in the risk of death or MI, whereas a 3% increase in rest defect burden or stress defect burden represented an 8% increase; these risks were the same for both cameras (P > .24, interaction tests).

Conclusions

The CZT camera has similar prognostic values for death and MI to conventional Anger cameras. This suggests that it may successfully be used to decrease patient dose.

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Figure 1
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Abbreviations

MI:

Myocardial infarction

CAD:

Coronary artery disease

SSS:

Summed stress score

SDS:

Summed difference score

SRS:

Summed rest score

SDB:

Stress defect burden

RDB:

Rest defect burden

DDB:

Difference defect burden

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Disclosures

Jorge Oldan, Paul Hofmann, Linda K. Shaw, Matthew Phelan, and Salvador Borges-Neto have no conflicts of interest. Jorge Oldan and Salvador Borges-Neto are affiliated with Duke University Medical Center. Paul Hofmann, Linda K. Shaw, and Matthew Phelan are associated with the Duke Clinical Research Institute.

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Authors and Affiliations

  1. Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, 2301 Erwin Road, Durham, NC, 27710, USA

    Jorge Daniel Oldan MD, Robert Pagnanelli BS & Salvador Borges-Neto MD

  2. Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC, 27705, USA

    Linda K. Shaw MS, Paul Hofmann BS & Matthew Phelan MS

  3. Clinical Imaging Physics Group, Department of Radiology, Duke University Medical Center, Durham, NC, 27705, USA

    Jeffrey Nelson MHP

  4. 11328 Euclid Avenue, Apt. 303, Cleveland, OH, 44106, USA

    Jorge Daniel Oldan MD

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  1. Jorge Daniel Oldan MD
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  2. Linda K. Shaw MS
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  3. Paul Hofmann BS
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  4. Matthew Phelan MS
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  7. Salvador Borges-Neto MD
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Correspondence to Jorge Daniel Oldan MD.

Additional information

See related editorial, doi:10.1007/s12350-015-0224-2.

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Oldan, J.D., Shaw, L.K., Hofmann, P. et al. Prognostic value of the cadmium-zinc-telluride camera: A comparison with a conventional (Anger) camera. J. Nucl. Cardiol. 23, 1280–1287 (2016). https://doi.org/10.1007/s12350-015-0181-9

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  • DOI: https://doi.org/10.1007/s12350-015-0181-9

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