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Relationship of decreased accumulation of 99mTc-tetrofosmin on myocardial single-photon emission computed tomography images between QRS duration in dilated cardiomyopathy patient with left bundle branch block

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Journal of Nuclear Cardiology Aims and scope

Abstract

Purpose

This study aimed to clarify the relationship between severity of conduction delay in the left ventricle and myocardial uptake of 99mTc-tetrofosmin (TF) in dilated cardiomyopathy (DCM) patients with left bundle branch block (LBBB).

Methods and Results

Thirty-two DCM patients with LBBB underwent electrocardiography and 99mTc-TF myocardial single-photon emission computed tomography (SPECT). SPECT images were acquired at 30 min (early images) and 3 h (late images) after injection. We calculated the total defect score (TDS) using a 20-segment model with a 5-point scoring system. The TDS in early and late images was defined as the summed early score (SES) and summed late score (SLS), respectively. On early images, 29 of 32 patients (91%) had decreased tracer uptake in the septum. All patients showed a decreased tracer uptake in the septum on late images. A significant correlation was observed between TDS (both SES and SLS) and QRS duration, with SLS showing an excellent correlation (SES: r = 0.554, P < 0.001; SLS: r = 0.779, P < 0.0001).

Conclusions

These findings suggest that in DCM patients with LBBB, hypoperfusion and myocardial damage in the septum might occur in accordance with an increase in the QRS duration.

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Authors and Affiliations

  1. Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Sachiko Takamine MD, Sei Fujiwara MD, Mayumi Shigeru MD, Tatsuro Ito MD & Ken-ichi Hirata MD

  2. Hyogo Brain and Heart Center, 7-10-2 Tomogaoka, Suma-ku, Kobe, Hyogo, Japan

    Hiroya Kawai MD

  3. Kobe University Graduate School of Health Sciences, 520 Saisyo, Himeji, Hyogo, Japan

    Hideyuki Shiotani MD

Authors
  1. Sachiko Takamine MD
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  2. Sei Fujiwara MD
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  3. Mayumi Shigeru MD
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  4. Tatsuro Ito MD
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  5. Hiroya Kawai MD
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  6. Hideyuki Shiotani MD
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  7. Ken-ichi Hirata MD
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Correspondence to Sachiko Takamine MD.

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Takamine, S., Fujiwara, S., Shigeru, M. et al. Relationship of decreased accumulation of 99mTc-tetrofosmin on myocardial single-photon emission computed tomography images between QRS duration in dilated cardiomyopathy patient with left bundle branch block. J. Nucl. Cardiol. 21, 1023–1028 (2014). https://doi.org/10.1007/s12350-014-9923-3

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  • DOI: https://doi.org/10.1007/s12350-014-9923-3

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