Abstract
Generally, the rose hips are discarded as horticultural wastes. Recently, they have been discovered to be storehouse of nutraceuticals and pharmaceuticals. Rich in polyphenols, essential fatty acids, vitamin A and C, mineral Ca and Fe, they have potential to be developed as functional foods. The extracts have demonstrated antioxidant, antiarthritic, antiinflammatory, analgesic, antidiabetic, cardioprotective, antimicrobial, immunomodulatory, gastroprotective and skin ameliorative effects. A slew of rose hip-based pharmaceutical supplements are already released to the market. Since very long, the indigenous traditional knowledge has accepted the medicinal value of rose hips. Now, modern clinical science is waking up to the rationale behind their incorporation in therapeutic regimens. This review has been compiled with a vision to promote the scarcely studied and barely exploited nutritional source as a nutraceutical aid and complementary and alternative medicine.
Similar content being viewed by others
References
Guo D, Xu L, Cao X, Guo Y, Ye Y, Chan C-O, Mok DKW, Yu Z, Chen S (2011) Anti-inflammatory activities and mechanisms of action of the petroleum ether fraction of Rosa multiflora Thunb. hips. J Ethnophrmacol 138:717–722
Chrubasik C, Roufogalis BD, Müller-Ladner U, Chrubasik S (2008) A systematic review on the Rosa canina effect and efficacy profiles. Phytother Res 22:725–733
Salminen J-P, Karonen M, Lempa K, Liimatainen J, Sinkkonen J, Lukkarinen M, Pihlaja K (2005) Characterisation of proanthocyanidin aglycones and glycosides from rose hips by high-performance liquid chromatography–mass spectrometry, and their rapid quantification together with vitamin C. J Chromatogr A 1077:170–180
Strålsjö L, Alklint C, Olsson ME, Sjöholm I (2003) Total folate content and retention in rosehips (Rosa ssp.) after drying. J Agric Food Chem 51:4291–4295
Andersson SC, Rumpunen K, Johansson E, Olsson ME (2011) Carotenoid content and composition in rose hips (Rosa spp.) during ripening, determination of suitable maturity marker and implications for health promoting food products. Food Chem 128:689–696
Yilmaz SO, Ercisli S (2011) Antibacterial and antioxidant activity of fruits of some rose species from Turkey. Romanian Biotechnol Lett 16 (4)
Evin D (2011) Investigation on the drying kinetics of sliced and whole rosehips at different moisture contents under microwave treatment. Sci Res Essays 6:2337–2347
Erenturk S, Gulaboglu MS, Gultekin S (2005) The effects of cutting and drying medium on the vitamin C content of rosehip during drying. J Food Eng 68:513–518
Mabellini A, Ohaco E, Ochoa MR, Kesseler AG, Márquez CA, De Michelis A (2011) Chemical and physical characteristics of several wild rose species used as food or food ingredient. Int J Ind Chem 2:158–171
Szentmihályi K, Vinkler P, Lakatos B, Illés V, Then M (2002) Rose hip (Rosa canina L.) oil obtained from waste hip seeds by different extraction methods. Bioresour Technol 82:195–201
Concha J, Soto C, Zuniaga ME (2004) Enzymatic pretreatment on rose-hip oil extraction: hydrolysis and pressing conditions. J Am Oil Chem Soc 81:549–552
Tozzi R, Mulinacci N, Storlikken K, Pasquali I, Vincieri FF, Bettini R (2008) Supercritical extraction of carotenoids from Rosa canina L. hips and their formulation with β-cyclodextrin. AAPS PharmSci Tech 9:693–700
Machmudah S, Kawahito Y, Sasaki M, Goto M (2008) Process optimization and extraction rate analysis of carotenoids extraction from rosehip fruit using supercritical CO2. J Supercrit Fluids 44:308–314
Güne M (2010) Pomological and phenological characteristics of promising rose hip (Rosa) genotypes. Afr J Biotechnol 9:6301–6306
Gharabaghi PM, Tabatabei F, Fard SA, Sayyah-Melli M, Ouladesahebmadarek E, Del Azar A, Khoei SA, Gharabaghi MM, Ghojazadeh M, Mashrabi O (2011) Evaluation of the effect of preemptive administration of Rosa damascena extract on post-operative pain in elective cesarean sections. Afr J Pharm Pharmacol 5:1950–1955
Barros L, Carvalho AM, Ferreira ICFR (2011) Exotic fruits as a source of important phytochemicals: improving the traditional use of Rosa canina fruits in Portugal. Food Res Int 44:2233–2236
Rosu CM, Manzu C, Olteanu Z, Oprica L, Oprea A, Ciornea E, Zamfirache MM (2011) Several fruit characteristics of Rosa sp. genotypes from the North-eastern region of Romania. Not Bot Horti Agrobo 39:203–208
Mocanu G-D, Rotaru G, Botez E, Gîtin L, Andronoiu D-G, Nistor O, Vlăsceanu G, Dune A (2009) Sensory evaluation and rheological behavior of probiotic dairy products with Rosa canina L. and Glycyrriza glabra L. extracts. Innov Romanian Food Biotechnol (4)
Bohm V, Frohlich K, Bitsch R (2003) Rosehip—a “new” source of lycopene? Mol Aspects Med 24:385–389
Wenzig EM, Widowitz U, Kunert O, Chrubasik S, Bucar F, Knauder E, Bauer R (2008) Phytochemical composition and in vitro pharmacological activity of two rose hip (Rosa canina L.) preparations. Phytomedicine 15:826–835
Gao X, Björk L, Trajkovski V, Uggla M (2000) Evaluation of antioxidant activities of rosehip ethanol extracts in different test systems Journal of the Science of Food and Agric 80:2021–2027
Yi O, Jovel EM, Towers GH, Wahbe TR, Cho D (2007) Antioxidant and antimicrobial activities of native Rosa sp. from British Columbia, Canada. Int J Food Sci Nutr 58:178–189
Yoo KM, Lee CH, Lee H, Moon BK, Lee CY (2008) Relative antioxidant and cytoprotective activities of common herbs. Food Chem 106:929–936
Rein E, Kharazmi A, Winther K (2004) A herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general well-being in patients with osteoarthritis-a double-blind, placebo-controlled, randomised trial. Phytomedicine 11:383–391
Winther K, Apel K, Thamsborg G (2005) A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol 34:302–308
Ameye LG, Chee WSS (2006) Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res Ther 8:R127
Chrubasik C, Duke RK, Chrubasik S (2006) The evidence for clinical efficacy of rose hip and seed: a systematic review. Phytother Res 20:1–3
Rossnagel K, Roll S, Willich SN (2007) The clinical effectiveness of rosehip powder in patients with osteoarthritis: a systematic review. MMW Fortschr Med 149:51–56
Jager AK, Petersen KN, Thomasen G, Christensen SB (2008) Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. Phytother Res 22:982–984
Christensen R, Bartels EM, Altman RD, Astrup A, Bliddal H (2008) Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients? A meta-analysis of randomized controlled trials. Osteoarthritis Cartilage 16:965–972
Cameron M, Gagnier JJ, Little CV, Parsons TJ, Blumle A, Chrubasik S (2009) Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part I: Osteoarthritis. Phytother Res 23:1497–1515
Willich SN, Rossnagel K, Roll S, Wagner A, Mune O, Erlendson J, Kharazmi A, Sörensen H, Winther K (2010) Rose hip herbal remedy in patients with rheumatoid arthritis: a randomised controlled trial. Phytomedicine 17:87–93
De Silva V, El-Metwally A, Ernst E, Lewith G, Macfarlane GJ (2011) Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review. Rheumatology (Oxford) 50:911–920
Deliorman OD, Harteviollu A, Küpeli E, Yesilada E (2007) In vivo anti-inflammatory and antinociceptive activity of the crude extract and fractions from Rosa canina fruits. J Ethnopharmacol 112:394–400
Lattanzio F, Greco E, Carretta D, Cervellati R, Govoni P, Speroni E (2011) In vivo anti-inflammatory effect of Rosa canina L. extract. Phytother Res 137:880–885
Larsen E, Kharazmi A, Christensen LP, Christensen SB (2003) An antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro. J Nat Prod 66:994–995
Schwager J, Hoeller U, Wolfram S, Richard N (2011) Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression. BMC Complement Alt Med 11:105
Orhan N, Aslan M, Hosbas S, Deliorman OD (2009) Antidiabetic effect and antioxidant potential of Rosa canina fruits. Pharmacog Mag 5:309–315
Andersson U, Henriksson E, Ström K, Alenfall J, Göransson O, Holm C (2011) Rose hip exerts anti-diabetic effects via a mechanism involving downregulation of the hepatic lipogenic program. Am J Physiol Endocrinol Metab 300:111–121
Andersson U, Berger K, Högberg A, Landin-Olsson M, Holm C (2011) Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clinical Nutrition. doi:10.1038/ejcn.2011.203
Saaby L, Nielsen CH (2011) Triterpene acids from rose hip powder inhibit self-antigen- and LPS-induced cytokine production and CD4 (+) T-cell proliferation in human mononuclear cell cultures. Phytother Res. doi:10.1002/ptr.3713
Saaby L, Jager AK, Moesby L, Hansen EW, Christensen SB (2011) Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). Phytother Res 25:195–201
Hakansson A, Stene C, mihaescu A, Molin G, Ahrne S, Thorlacius H, Jeppsson B (2006) Rose hip and Lactobacillus plantarum DSM 9843 reduce ischemia/reperfusion injury in the mouse colon. Digest Dis Sci 51:2094–2101
Fujii T, Saito M (2009) Inhibitory effect of quercetin isolated from rose hip (Rosa canina L.) against melanogenesis by mouse melanoma cells. Biosci Biotechnol Biochem 73:1989–1993
Fujii T, Ikeda K, Saito M (2011) Inhibitory effect of rose hip (Rosa canina L.) on melanogenesis in mouse melanoma cells and on pigmentation in brown guinea pigs. Biosci Biotechnol Biochem 75:489–495
Werlemark G (2009) Dog rose: wild plant, bright future. Chron Hortic 49:8–13
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Patel, S. Rose hips as complementary and alternative medicine: overview of the present status and prospects. Mediterr J Nutr Metab 6, 89–97 (2013). https://doi.org/10.1007/s12349-012-0118-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12349-012-0118-7